The neuroendocrinological role of P-glycoprotein

2005 ◽  
Vol 113 (08) ◽  
Author(s):  
M Ebinger ◽  
MB Müller ◽  
M Uhr
Keyword(s):  
P Glycoprotein

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms

Role of P-glycoprotein in Statin Drug Interactions

2006 ◽  
Vol 26 (11) ◽  
pp. 1601-1607 ◽  
Author(s):  
Carol W Holtzman ◽  
Barbara S Wiggins ◽  
Sarah A Spinler
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein ◽  
Statin Drug

scholarly journals Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0204693 ◽  
Author(s):  
Andaleeb Sajid ◽  
Sabrina Lusvarghi ◽  
Eduardo E. Chufan ◽  
Suresh V. Ambudkar
Keyword(s):  
Critical Role ◽  
Transmembrane Helices ◽  
Substrate Transport ◽  
P Glycoprotein

scholarly journals THE ROLE OF P-GLYCOPROTEIN IN RATIONAL PHARMACOTHERAPY IN CARDIOLOGY

2013 ◽  
Vol 9 (6) ◽  
pp. 701-707 ◽  
Author(s):  
A. V. Shulkin ◽  
E. N. Yakusheva ◽  
N. M. Popova
Keyword(s):  
Rational Pharmacotherapy ◽  
P Glycoprotein

scholarly journals Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

2021 ◽  
Author(s):  
Robert W. Robey ◽  
Andrea N. Robinson ◽  
Fatima Ali-Rahmani ◽  
Lyn M. Huff ◽  
Sabrina Lusvarghi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Multidrug Transporter ◽  
Glycoprotein P ◽  
Tissue Localization ◽  
Brain Vasculature ◽  
P Glycoprotein ◽  
Capillary Endothelial Cells ◽  
The Brain ◽  
Viable Model

ABSTRACTGiven its similarities with mammalian systems, the zebrafish has emerged as a potential model to study the blood-brain barrier (BBB). Capillary endothelial cells at the human BBB express high levels of P-glycoprotein (P-gp, encoded by the ABCB1 gene) and ABCG2 (encoded by the ABCG2 gene). However, little information has been available about ATP-binding cassette transporters expressed at the zebrafish BBB. In this study, we focus on the characterization and tissue localization of two genes that are similar to human ABCB1, zebrafish abcb4 and abcb5. Cytotoxicity assays with stably-transfected cell lines revealed that zebrafish Abcb5 cannot efficiently transport the substrates doxorubicin and mitoxantrone compared to human P-gp and zebrafish Abcb4. Additionally, zebrafish Abcb5 did not transport the fluorescent probes BODIPY-ethylenediamine or LDS 751, while they were readily transported by Abcb4 and P-gp. A high-throughput screen conducted with 90 human P-gp substrates confirmed that zebrafish Abcb4 has overlapping substrate specificity with P-gp. Basal ATPase activity of zebrafish Abcb4 and Abcb5 was comparable to that of human P-gp. In the brain vasculature, RNAscope probes to detect abcb4 colocalized with staining by the P-gp antibody C219, while abcb5 was not detected. Zebrafish abcb4 also colocalized with claudin-5 expression in brain endothelial cells. Abcb4 and Abcb5 had different tissue localizations in multiple zebrafish tissues, consistent with different functions. The data suggest that zebrafish Abcb4 most closely phenocopies P-gp and that the zebrafish may be a viable model to study the role of the multidrug transporter P-gp at the BBB.

Role of P-glycoprotein in transplacental transfer of methadone

2003 ◽  
Vol 189 (6) ◽  
pp. S124 ◽  
Author(s):  
Tatiana Nanovskaya ◽  
Ilona Nekhayeva ◽  
Olga Zharikova ◽  
Gary Hankins ◽  
Mahmoud Ahmed
Keyword(s):  
Transplacental Transfer ◽  
P Glycoprotein

A Possible Role of P-Glycoprotein in BSE

2013 ◽  
Vol 148 (1) ◽  
pp. 73
Author(s):  
S. Van der Heyden ◽  
B. Wegge ◽  
A. Dobly ◽  
R. Ducatelle ◽  
S. Roels
Keyword(s):  
P Glycoprotein
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