Interactome analysis of the EV71 5′ untranslated region in differentiated neuronal cells SH-SY5Y and regulatory role of FBP3 in viral replication

PROTEOMICS ◽  
2016 ◽  
Vol 16 (17) ◽  
pp. 2351-2362 ◽  
Author(s):  
Hsing-I Huang ◽  
Ying-Ying Chang ◽  
Jhao-Yin Lin ◽  
Rei-Lin Kuo ◽  
Hao-Ping Liu ◽  
...  
Keyword(s):  
Viral Replication ◽  
Untranslated Region ◽  
Neuronal Cells ◽  
Regulatory Role

A Review of the Regulatory Role of Nicotinamide on Pro- and Anti-apoptotic Proteins in Neuronal Cells

2005 ◽  
Vol 2 (7) ◽  
pp. 551-557 ◽  
Author(s):  
S. Mukherjee ◽  
M. Sonee ◽  
Bentham Science Publisher J. D. Adams Jr
Keyword(s):  
Neuronal Cells ◽  
Regulatory Role ◽  
Apoptotic Proteins

Regulatory Role of the 3' Untranslated Region (3'UTR) of Rat 5' Deiodinase (D1). Effects on Messenger RNA Translation and Stability

Endocrine ◽  
2005 ◽  
Vol 27 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Omar Arroyo-Helguera ◽  
Carmen Mejía-Viggiano ◽  
Alfredo Varela-Echavarría ◽  
Marcos Cajero-Juárez ◽  
Carmen Aceves
Keyword(s):  
Messenger Rna ◽  
Untranslated Region ◽  
Regulatory Role ◽  
Rna Translation ◽  
Messenger Rna Translation

scholarly journals The Transcriptome-Wide N6-Methyladenosine (m6A) Map Profiling Reveals the Regulatory Role of m6A in the Yak Ovary

2021 ◽  
Author(s):  
Shaoke Guo ◽  
Xingdong Wang ◽  
Mengli Cao ◽  
Xiaoyun Wu ◽  
Lin Xiong ◽  
...  
Keyword(s):  
Untranslated Region ◽  
Follicular Development ◽  
Distribution Patterns ◽  
Regulatory Role ◽  
Ovarian Activity ◽  
Conserved Sequence ◽  
Rna Immunoprecipitation ◽  
Solid Foundation ◽  
Regulation Of Synthesis

Abstract Background and aim: Yak estrus is a seasonal phenomenon, probably involving epigenetic regulation of synthesis and secretion of sex hormones as well as growth and development of follicles. N6-methyladenosine (m6A) is the most common internal modification of the eukaryotic mRNA. However, there are no detailed reports on the m6A transcriptome map of yak ovary. Therefore, this study aimed to collected the yak ovarian tissues at three different states of anestrus (YO-A), estrus (YO-F), and pregnancy (YO-P), and obtained the full transcriptome m6A map in yak by MeRIP-seq. Results: The HE staining revealed that the number of growing follicles and mature follicles in the ovary during the estrus period was relatively higher than those in the estrus period and the pregnancy period. The RT-qPCR showed that the expression of METTL3, METTL14, FTO, YTHDC1 were significantly different across different periods in the ovaries, which suggests that m6A may play a regulatory role in ovarian activity. Next, we identified 20174, 19747 and 13523 m6A peaks in the three ovarian samples of YO-A, YO-F and YO-P using the methylated RNA immunoprecipitation sequencing (MeRIP-seq). The m6A peaks are highly enriched in the coding sequence (CDS) region and 3′untranslated region (3′UTR) as well as the conserved sequence of “RRACH.” Functional analysis revealed the involvement of m6A in many physiological activities of the yak’s ovary during reproductive cycle. The association analysis found that some genes such as BNC1, HOMER1, BMP15, BMP6, GPX3, and WNT11 were related to ovarian functions. Conclusions: The comparison of the distribution patterns of methylation peaks in the ovarian tissues across different periods further explored the m6A markers related to the regulation of ovarian ovulation and follicular development in the yak ovary. This comprehensive map provides a solid foundation for revealing the potential function of the mRNA m6A modification in the yak ovary.

Potential Regulatory Role of the Conversed Elements inSox2 3'Untranslated Region

2010 ◽  
Vol 30 (6) ◽  
pp. 633-638 ◽  
Author(s):  
Li MA ◽  
Qing-hua KONG ◽  
Shu-hua ZHAO ◽  
Yun-hu WEI ◽  
Bing-yu MAO
Keyword(s):  
Untranslated Region ◽  
Regulatory Role ◽  
Potential Regulatory Role

Regulatory role of resistin on ovarian function

2014 ◽  
Author(s):  
Agnieszka Rak-Mardyla ◽  
Anna Wrobel ◽  
Eliza Drwal ◽  
Ewa Gregoraszczuk
Keyword(s):  
Ovarian Function ◽  
Regulatory Role
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