An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM)

PROTEOMICS ◽  
2014 ◽  
Vol 14 (12) ◽  
pp. 1445-1456 ◽  
Author(s):  
Scott Peterman ◽  
Eric E. Niederkofler ◽  
David A. Phillips ◽  
Bryan Krastins ◽  
Urban A. Kiernan ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Serum ◽  
High Throughput ◽  
Mass Spectrometric ◽  
Accurate Mass ◽  
Mass Detection ◽  
High Throughput Method ◽  
Plasma Coupling

High throughput method for the determination of organochlorine pesticides and polychlorinated biphenyls in human serum

2007 ◽  
Vol 852 (1-2) ◽  
pp. 15-21 ◽  
Author(s):  
Fernando Goñi ◽  
Raul López ◽  
Arsenio Etxeandia ◽  
Esmeralda Millán ◽  
Pilar Amiano
Keyword(s):  
Polychlorinated Biphenyls ◽  
Human Serum ◽  
Organochlorine Pesticides ◽  
High Throughput ◽  
High Throughput Method

Novel hydrophilic-phase extraction, HILIC and high-resolution MS quantification of an RNA oligonucleotide in plasma

Bioanalysis ◽  
2021 ◽  
Author(s):  
Prachi Anand ◽  
Michael Koleto ◽  
Dilipkumar R Kandula ◽  
Lei Xiong ◽  
Robert MacNeill
Keyword(s):  
High Resolution ◽  
High Performance ◽  
Dynamic Range ◽  
Solid Phase ◽  
Accurate Mass ◽  
Phase Extraction ◽  
Linear Dynamic Range ◽  
Mass Detection ◽  
Hydrophilic Interaction ◽  
High Recovery

Aim: In the theme of quantitative LC–MS bioanalysis of oligonucleotides free of ion-pairing, a 22-mer RNA oligonucleotide took center stage. The focus was on a unique polar-based retention scheme to produce a high-recovery extraction presenting a high-performance alternative extraction means, also there was the opportunity to involve hydrophilic-interaction liquid chromatography and contemporary high-resolution MS as the end point. Results: Original LC–MS methodology was developed for the oligonucleotide and the performance was robust for both nominal and accurate mass detection, the latter affording 10× improvement in sensitivity and 4000-fold linear dynamic range, 500 pM to 2000 nM. Conclusion: A novel means of solid-phase extraction is exhibited within a robust pair-free methodology, reaching pM sensitivity with the demonstrably beneficial accurate mass platform.

High-Resolution and High-Throughput Protocols for Measuring Drug/Human Serum Albumin Interactions Using BIACORE

2001 ◽  
Vol 296 (2) ◽  
pp. 197-207 ◽  
Author(s):  
Rebecca L. Rich ◽  
Yasmina S.N. Day ◽  
Thomas A. Morton ◽  
David G. Myszka
Keyword(s):  
High Resolution ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
High Throughput

Multiplex single nucleotide extension (MSNE): a robust and high throughput method for high-resolution HLA-A locus typing

2003 ◽  
Vol 64 (10) ◽  
pp. S92
Author(s):  
Mei Han ◽  
Yue-Qing Tan ◽  
Yanzheng Zhang ◽  
Jeannette Tsai ◽  
Robert Vorhaben ◽  
...  
Keyword(s):  
High Resolution ◽  
High Throughput ◽  
Single Nucleotide ◽  
High Throughput Method
Sign in / Sign up

Export Citation Format

Share Document