scholarly journals An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

2016 ◽  
Vol 44 (10) ◽  
pp. 1653-1661 ◽  
Author(s):  
P. Shah ◽  
E. Kerns ◽  
D.-T. Nguyen ◽  
R. S. Obach ◽  
A. Q. Wang ◽  
...  
Keyword(s):  
Data Analysis ◽  
High Resolution ◽  
High Throughput ◽  
Metabolic Stability ◽  
Accurate Mass ◽  
Analysis Software ◽  
Automated Data Analysis ◽  
High Resolution Accurate Mass ◽  
Data Analysis Software

scholarly journals Current trends in flow cytometry automated data analysis software

2021 ◽  
Author(s):  
Melissa Cheung ◽  
Jonathan J. Campbell ◽  
Liam Whitby ◽  
Robert J. Thomas ◽  
Julian Braybrook ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Data Analysis ◽  
Analysis Software ◽  
Current Trends ◽  
Automated Data Analysis ◽  
Data Analysis Software

Abstract 1667: A robust human immune profiling assay using CyTOF technology and automated data analysis software

2019 ◽  
Author(s):  
Stephen K. Li ◽  
Daniel Majonis ◽  
C. Bruce Bagwell ◽  
Benjamin C. Hunsberger ◽  
Vladimir I. Baranov ◽  
...  
Keyword(s):  
Data Analysis ◽  
Analysis Software ◽  
Human Immune ◽  
Automated Data Analysis ◽  
Immune Profiling ◽  
Data Analysis Software

Abstract 1667: A robust human immune profiling assay using CyTOF technology and automated data analysis software

2019 ◽  
Author(s):  
Stephen K. Li ◽  
Daniel Majonis ◽  
C. Bruce Bagwell ◽  
Benjamin C. Hunsberger ◽  
Vladimir I. Baranov ◽  
...  
Keyword(s):  
Data Analysis ◽  
Analysis Software ◽  
Human Immune ◽  
Automated Data Analysis ◽  
Immune Profiling ◽  
Data Analysis Software

Analysis of Squalene and Its Transformation By-Products in Latent Fingermarks by Ultrahigh-Pressure Liquid Chromatography-High Resolution Accurate Mass Orbitrap™ Mass Spectrometry

2019 ◽  
Author(s):  
Buddhika Dorakumbura ◽  
Francesco Busetti ◽  
Simon Lewis
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Resolution ◽  
Storage Conditions ◽  
Ultrahigh Pressure ◽  
Accurate Mass ◽  
Rational Approach ◽  
By Products ◽  
Over Time ◽  
High Resolution Accurate Mass

<p>Transformation of squalene and its by-products in fingermarks over time under different storage conditions (light, dark and underwater) was examined through ultrahigh-pressure liquid chromatography high resolution accurate mass Orbitrap™ mass spectrometry. Complications of assessing fingermark compositional variation over time using multiple samples with varying initial compositions were elucidated and a more rational approach was successfully demonstrated. Squalene was detected in all fresh natural fingermarks and the amount ranged between 0.20 to 11.32 μg/5 fingertips. A notable difference in the transformation of squalene was observed with different storage conditions, where a dark aquatic environment accelerated degradation of squalene compared to dark but dry conditions. Squalene monohydroperoxide was extremely short-lived in natural deposits while the amount of squalene epoxide was still increasing relative to the initial amount, after ageing under dark and aquatic conditions for up to 7 days. Some oxidation by-products of cholesterol were also tentatively identified, which exhibited a growth over time against their initial concentration under any of the storage condition tested. These by-products, therefore, show potential as biomarkers for targeted visualisation of aged deposits.</p>

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