Functional annotation of proteins identified in human brain during the HUPO Brain Proteome Project pilot study

PROTEOMICS ◽  
2006 ◽  
Vol 6 (18) ◽  
pp. 5059-5075 ◽  
Author(s):  
Michael Mueller ◽  
Lennart Martens ◽  
Kai A. Reidegeld ◽  
Michael Hamacher ◽  
Christian Stephan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Human Brain ◽  
Functional Annotation ◽  
Brain Proteome

Human brain proteome in health and disease

2016 ◽  
Vol 10 (12) ◽  
pp. 1147-1147 ◽  
Author(s):  
Renã A. S. Robinson ◽  
Melanie Föcking ◽  
Daniel Martins-de-Souza
Keyword(s):  
Human Brain ◽  
Brain Proteome ◽  
Health And Disease

A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption

2021 ◽  
Author(s):  
Chun'e Li ◽  
Xiao Liang ◽  
Yumeng Jia ◽  
Yan Wen ◽  
Huijie Zhang ◽  
...  
Keyword(s):  
Human Brain ◽  
Association Study ◽  
Plasma Proteins ◽  
Genome Wide Association Study ◽  
Genetic Correlations ◽  
Coffee Consumption ◽  
Genetic Associations ◽  
Brain Proteins ◽  
Genome Wide ◽  
Brain Proteome

Abstract Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee consumption subtypes was performed by integrating two independent genome-wide association study (GWAS) datasets (91,462–502,650 subjects) with two reference human brain proteomes (ROS/MAP and Banner), by using the FUSION pipeline. Second, transcriptome-wide association study (TWAS) analysis of coffee consumption subtypes was conducted by integrating the two gene expression weight references (RNAseq and splicing) of brain RNA-seq and the two GWAS datasets (91,462–502,650 subjects) of coffee consumption subtypes. Finally, we used the LD Score Regression (LDSC) analysis to evaluate the genetic correlations of coffee consumption subtypes with plasma proteomes and peripheral metabolites. Results For the traits related to coffee consumption, we identified 3 common PWAS proteins, such as MADD (P PWAS−Banner−dis=0.0114, P PWAS−ROS/MAP−rep =0.0489). In addition, 11 common TWAS genes were found in two cohorts, such as ARPC2 (P TWAS−splicing−dis =2063×10− 12, P TWAS−splicing−dis =1.25×10− 10, P TWAS−splicing−dis =1.24e-08, P TWAS−splicing−rep =3.25×10− 9 and P TWAS−splicing−rep =3.42×10− 13). Importantly, we have identified 8 common genes between PWAS and TWAS, such as ALDH2 (P PWAS−banner−rep =1.22×10− 22, PTWAS− splicing−dis = 4.54×10− 92). For the LDSC analysis of human plasma proteome, we identified 11 plasma proteins, such as CHL1 (P dis = 0.0151, P rep =0.0438). For the LDSC analysis of blood metabolites, 5 metabolites have been found, such as myo-inositol (P dis = 0.0073, P dis = 0.0152, P dis =0.0414, P rep =0.0216). Conclusions We identified several brain proteins and genes associated with coffee consumption subtypes. In addition, we also detected several candidate plasma proteins and metabolites related to these subtypes.

Human Brain Proteome-Wide Association Study of Depression Identified 24 Proteins as Tractable Targets for Further Mechanistic Studies

2020 ◽  
Vol 87 (9) ◽  
pp. S183
Author(s):  
Thomas S. Wingo ◽  
Yue Liu ◽  
Adriana Lori ◽  
Ekaterina S. Gerasimov ◽  
Duc M. Duong ◽  
...  
Keyword(s):  
Human Brain ◽  
Association Study ◽  
Mechanistic Studies ◽  
Brain Proteome

F94. Human Brain Proteome-Wide Association Study of Longitudinally Assessed Late-Life Depression

2019 ◽  
Vol 85 (10) ◽  
pp. S249
Author(s):  
Aliza Wingo ◽  
Wen Fan ◽  
Nicholas Seyfried ◽  
Duc Duong ◽  
Eric Dammer ◽  
...  
Keyword(s):  
Human Brain ◽  
Association Study ◽  
Late Life ◽  
Late Life Depression ◽  
Brain Proteome

scholarly journals 25 FUNCTIONAL ANNOTATION OF RARE STRUCTURAL VARIATION IN THE HUMAN BRAIN

2019 ◽  
Vol 29 ◽  
pp. S72-S73 ◽  
Author(s):  
Lide Han ◽  
Xuefang Zhao ◽  
Mary Lauren Benton ◽  
Thaneer Perumal ◽  
Ryan Collins ◽  
...  
Keyword(s):  
Human Brain ◽  
Functional Annotation ◽  
Structural Variation

Gel-free analysis of the human brain proteome: Application of liquid chromatography and mass spectrometry on biopsy and autopsy samples

PROTEOMICS ◽  
2006 ◽  
Vol 6 (18) ◽  
pp. 4967-4977 ◽  
Author(s):  
Debora Dumont ◽  
Jean-Paul Noben ◽  
Peter Verhaert ◽  
Piet Stinissen ◽  
Johan Robben
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Brain ◽  
Brain Proteome

Great mood in proteomics: Beijing and the HUPO Human Brain Proteome Project

PROTEOMICS ◽  
2005 ◽  
Vol 5 (2) ◽  
pp. 334-336 ◽  
Author(s):  
Michael Hamacher ◽  
Helmut E. Meyer
Keyword(s):  
Human Brain ◽  
Brain Proteome

Creating a Human Brain Proteome Atlas - 13th HUPO BPP Workshop March 30-31, 2010, Ochang, Korea

PROTEOMICS ◽  
2011 ◽  
Vol 11 (14) ◽  
pp. 2759-2762
Author(s):  
Bernd Gröttrup ◽  
Christian Stephan ◽  
Katrin Marcus ◽  
Lea T. Grinberg ◽  
Jens Wiltfang ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Proteome

scholarly journals Human Brain Proteome Project

2003 ◽  
Vol 2 (6) ◽  
pp. 576-576
Author(s):  
Hanns J. Neubert
Keyword(s):  
Human Brain ◽  
Brain Proteome
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