Clinical-scale high-throughput human plasma proteome analysis: Lung adenocarcinoma

PROTEOMICS ◽  
2005 ◽  
Vol 5 (4) ◽  
pp. 1150-1159 ◽  
Author(s):  
Kiyonaga Fujii ◽  
Tomoyo Nakano ◽  
Mitsuhiro Kanazawa ◽  
Shingo Akimoto ◽  
Takashi Hirano ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Plasma ◽  
High Throughput ◽  
Proteome Analysis ◽  
Clinical Scale ◽  
Plasma Proteome ◽  
Human Plasma Proteome

scholarly journals In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Maria Pernemalm ◽  
AnnSofi Sandberg ◽  
Yafeng Zhu ◽  
Jorrit Boekel ◽  
Davide Tamburro ◽  
...  
Keyword(s):  
Human Plasma ◽  
Genomic Sequence ◽  
Proteome Analysis ◽  
Protein Profiling ◽  
Single Amino Acid ◽  
Sequence Information ◽  
Plasma Proteome ◽  
Multiple Protein ◽  
Protein Variants ◽  
Human Plasma Proteome

Here, we present a method for in-depth human plasma proteome analysis based on high-resolution isoelectric focusing HiRIEF LC-MS/MS, demonstrating high proteome coverage, reproducibility and the potential for liquid biopsy protein profiling. By integrating genomic sequence information to the MS-based plasma proteome analysis, we enable detection of single amino acid variants and for the first time demonstrate transfer of multiple protein variants between mother and fetus across the placenta. We further show that our method has the ability to detect both low abundance tissue-annotated proteins and phosphorylated proteins in plasma, as well as quantitate differences in plasma proteomes between the mother and the newborn as well as changes related to pregnancy.

High confidence and sensitivity four-dimensional fractionation for human plasma proteome analysis

Amino Acids ◽  
2012 ◽  
Vol 43 (5) ◽  
pp. 2199-2202 ◽  
Author(s):  
Renato Millioni ◽  
Serena Tolin ◽  
Gian Paolo Fadini ◽  
Marco Falda ◽  
Bas van Breukelen ◽  
...  
Keyword(s):  
Human Plasma ◽  
Proteome Analysis ◽  
Plasma Proteome ◽  
High Confidence ◽  
Human Plasma Proteome

Human plasma proteome analysis by reversed sequence database search and molecular weight correlation based on a bacterial proteome analysis

PROTEOMICS ◽  
2006 ◽  
Vol 6 (4) ◽  
pp. 1121-1132 ◽  
Author(s):  
Gun Wook Park ◽  
Kyung-Hoon Kwon ◽  
Jin Young Kim ◽  
Jeong Hwa Lee ◽  
Sung-Ho Yun ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Human Plasma ◽  
Proteome Analysis ◽  
Database Search ◽  
Plasma Proteome ◽  
Sequence Database ◽  
Sequence Database Search ◽  
Human Plasma Proteome

The human plasma proteome: Analysis of Chinese serum using shotgun strategy

PROTEOMICS ◽  
2005 ◽  
Vol 5 (13) ◽  
pp. 3442-3453 ◽  
Author(s):  
Ping He ◽  
Hong-Zhi He ◽  
Jie Dai ◽  
Ying Wang ◽  
Quan-Hu Sheng ◽  
...  
Keyword(s):  
Human Plasma ◽  
Proteome Analysis ◽  
Plasma Proteome ◽  
Human Plasma Proteome
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