Novel pH, ion sensitive polyampholyte gels based on carboxymethyl chitosan and gelatin

2003 ◽  
Vol 52 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Lingyun Chen ◽  
Yumin Du ◽  
Ronghua Huang
Keyword(s):  
Carboxymethyl Chitosan ◽  
Polyampholyte Gels

Carboxymethyl-hexanoyl Chitosan Nanodroplets for Ultrasonic Imaging and Drug Delivery to Tumor

2018 ◽  
Vol 24 (15) ◽  
pp. 1682-1688 ◽  
Author(s):  
Yu Jinsui ◽  
Situ Bing ◽  
Luo Muhua ◽  
Li Yue ◽  
Liao Jianyi ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan ◽  
Great Promise ◽  
Ovarian Cancer Cells ◽  
Mechanical Index ◽  
Surface Charges ◽  
Particle Structure ◽  
Drug Release Profile ◽  
Hexanoyl Chitosan

Introduction: Although a great many strategies have been proposed for tumor-targeted chemotherapy, current delivery methods of anticancer drugs present limited success with inevitable systemic toxicity. The aim of this study was to develop a new kind of theranostic carrier for targeted tumor therapy. Methods: Prior to prepare CHC-PFP-DOX, carboxymethyl-hexanoyl chitosan (CHC) was synthesized by acylation of carboxymethyl chitosan. To develop CHC-PFP, perfluoropentane (PFP), an ultrasound gas precursor, was simultaneously encapsulated into the hydrophobic inner cores of pre-formulated CHC micelle in aqueous phase via using the oil in water (O/W) emulsion method. The size distribution and surface charges of these nanodroplets were measured and the morphology was observed by transmission electron microscopy (TEM). For ultrasound imaging application, in vitro model was established to evaluate the imaging of CHC-PFP-DOX under different concentration and mechanical index. After that, the anti-tumor effect of ultrasound combined with CHC-PFPDOX on ovarian cancer cells was investigated. Results: The resulting CHC-PFP-DOX had a nano-sized particle structure, with hydrophobic anticancer DOX/PFP inner cores and a hydrophilic carboxymethyl chitosan polymer outer shell. The favorable nano-scaled size offers the potential to extravagate from veins and accumulate in tumor tissues via enhanced permeation and retention (EPR) effect. Additionally, CHC-PFP-DOX showed the ability to serve as ultrasound imaging agent at body temperature. Notably, it exhibited an ultrasound-triggered drug release profile through the external ultrasound irradiation. Further study demonstrated that ultrasound combined with CHC-PFP-DOX can improve the killing effect of chemotherapy for tumor. Conclusion: CHC-PFP-DOX holds great promise in simultaneous cancer-targeting ultrasound imaging and ultrasound- mediated delivery for cancer chemotherapy.

Preparation, Characterization and Antibacterial Activity of Quaternized Carboxymethyl Chitosan/Organic Rectorite Nanocomposites

2013 ◽  
Vol 9 (2) ◽  
pp. 278-282 ◽  
Author(s):  
Xiaoyun Li ◽  
Yang Han ◽  
Haoquan Zhong ◽  
Weijie Ye ◽  
Bo Liu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carboxymethyl Chitosan

Smart flame retardant coating containing carboxymethyl chitosan nanoparticles decorated graphene for obtaining multifunctional textiles

Cellulose ◽  
2021 ◽  
Author(s):  
Emad S. Goda ◽  
Mahmoud H. Abu Elella ◽  
Sang Eun Hong ◽  
Bidhan Pandit ◽  
Kuk Ro Yoon ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan

Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect

2021 ◽  
Author(s):  
Mengyu Yao ◽  
Qingxia Zou ◽  
Wenwu Zou ◽  
Zhenze Xie ◽  
Zhihao Li ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan

Bifunctional scaffolds prepared by hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with good osteogenesis and anti-osteosarcoma effect is promising for bone tumor therapy.

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