Hydrogen-bonding interaction of an alternating maleic acid-vinyl acetate copolymer with poly(ethylene glycol), polyacrylamide and poly(N-isopropylacrylamide): a comparative study

2003 ◽  
Vol 52 (12) ◽  
pp. 1887-1891 ◽  
Author(s):  
C Vasile ◽  
GG Bumbu ◽  
Y Mylonas ◽  
I Cojocaru ◽  
G Staikos
Keyword(s):  
Hydrogen Bonding ◽  
Ethylene Glycol ◽  
Comparative Study ◽  
Vinyl Acetate ◽  
Maleic Acid ◽  
Hydrogen Bonding Interaction ◽  
Poly Ethylene Glycol ◽  
Bonding Interaction ◽  
Poly Ethylene ◽  
Acetate Copolymer

Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice

2019 ◽  
Vol 14 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Batool Hashemi-Beni ◽  
Mohsen Minaiyan ◽  
Saeedeh Enteshari
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Tissue Distribution ◽  
Tumor Cells ◽  
Maleic Acid ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ether Ester

Background: Due to the low water solubility of Docetaxel (DTX), it is formulated with ethanol and Tween 80 with lots of side effects. For this reason, special attention has been paid to formulate it in new drug nano-carriers. Objective: The goal of this study was to evaluate the safety, antitumor activity and tissue distribution of the novel synthesized Raloxifene (RA) targeted polymeric micelles. Methods: DTX-loaded RA-targeted polymeric micelles composed of poly(styrene-maleic acid)- poly(amide-ether-ester-imide)-poly(ethylene glycol) (SMA-PAEE-PEG) were prepared and their antitumor activity was studied in MC4-L2 tumor-bearing mice compared with non-targeted micelles and free DTX. Safety of the micelles was studied by Hematoxylin and Eosin (H&E) staining of tumors and major organs of the mice. The drug accumulation in the tumor and major organs was measured by HPLC method. Results: The results showed better tumor growth inhibition and increased survival of mice treated with DTX-loaded in targeted micelles compared to the non-targeted micelles and free DTX. Histopathological studies, H&E staining of tumors and immunohistochemical examination showed the potential of DTX-loaded RA-targeted micelles to inhibit tumor cells proliferation. The higher accumulation of the DTX in the tumor tissue after injection of the micelles compared to the free DTX may indicate the higher uptake of the targeted micelles by the G-Protein-Coupled Estrogen Receptors (GPER). Conclusion: The results indicate that RA-conjugated polymeric micelles may be a strong and effective drug delivery system for DTX therapy and uptake of the drug into tumor cells, and overcome the disadvantages and side effects of conventional DTX.

The role of hydrogen bonding in alginate/poly(acrylamide-co-dimethylacrylamide) and alginate/poly(ethylene glycol) methyl ether methacrylate-based tough hybrid hydrogels

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57678-57685 ◽  
Author(s):  
Zhi Wei Low ◽  
Pei Lin Chee ◽  
Dan Kai ◽  
Xian Jun Loh
Keyword(s):  
Hydrogen Bonding ◽  
Elastic Modulus ◽  
Ethylene Glycol ◽  
Methyl Ether ◽  
Poly Ethylene Glycol ◽  
Hybrid Hydrogels ◽  
Poly Ethylene ◽  
Glycol Methyl Ether ◽  
Poly Acrylamide

Hybrid hydrogels, with an elastic modulus and compressive toughness of 350 kPa and 70 J m−3, was synthesized and reported here.

Poly(ethylene glycol)-graft-poly(vinyl acetate) single-chain nanoparticles for the encapsulation of small molecules

2017 ◽  
Vol 19 (6) ◽  
pp. 4553-4559 ◽  
Author(s):  
Arianna Bartolini ◽  
Paolo Tempesti ◽  
Claudio Resta ◽  
Debora Berti ◽  
Johan Smets ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Small Molecules ◽  
Vinyl Acetate ◽  
Hydrodynamic Radius ◽  
Hydrophobic Interactions ◽  
Single Chain ◽  
Poly Ethylene Glycol ◽  
Low Degree ◽  
Poly Ethylene

Amphiphilic poly(ethylene glycol)-graft-poly(vinyl acetate) copolymers with a low degree of grafting undergo self-folding in water driven by hydrophobic interactions, resulting in single-chain nanoparticles (SCNPs) possessing a hydrodynamic radius of about 10 nm.

scholarly journals Associative properties of poly(ethylene glycol)–poly(vinyl acetate) comb-like graft copolymers in water

Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6635-6643 ◽  
Author(s):  
Marianna Mamusa ◽  
Paolo Tempesti ◽  
Arianna Bartolini ◽  
Emiliano Carretti ◽  
Ahmad F. Ghobadi ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Vinyl Acetate ◽  
Graft Copolymers ◽  
Polymer Concentration ◽  
Complex Structures ◽  
Single Chain ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A PEG-graft-PVAc comb-like copolymer in water forms spherical single-chain nanoparticles that transition towards hierarchically complex structures with increasing polymer concentration.

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