Novel strategy for encapsulation and targeted delivery of poorly water‐soluble active substances

2020 ◽  
Vol 60 (8) ◽  
pp. 2008-2022
Author(s):  
Maja D. Markovic ◽  
Vesna V. Panic ◽  
Sanja I. Seslija ◽  
Ana D. Milivojevic ◽  
Pavle M. Spasojevic ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Water Soluble ◽  
Poorly Water Soluble ◽  
Novel Strategy ◽  
Active Substances

scholarly journals Plant Extract Loaded Nanoparticles

2021 ◽  
Vol 3 (1) ◽  
pp. 38
Author(s):  
Patihul Husni ◽  
Zelika Mega Ramadhania
Keyword(s):  
Plant Extract ◽  
Plant Extracts ◽  
Targeted Delivery ◽  
Complex Mixture ◽  
Control Release ◽  
Water Soluble ◽  
Flexible Control ◽  
Taste And Odor ◽  
Low Toxicity ◽  
Poorly Water Soluble

Plant extract, a natural source containing complex mixture of compounds, offers many properties such as antiparasitic, antibiotic, antioxidant, anti-hypertensive, antiviral, insecticide, anticancer, antifungal, hypoglycemic properties. Recent research has been focused on developing formulation the plant extracts not only to deliver them safely but also to enhance its therapeutic efficacy. Nanotechnology-based strategies have been proposed as a system that can be used to formulate plant extracts. Plant extract loaded nanoparticles (NPs) is aimed to facilitate in crossing the biological barriers, to increase bioavailability of poorly water-soluble phytochemicals, to encapsulate mixture compounds of different phytochemicals, to provide targeted delivery of phytochemicals to specific organs resulting in low toxicity, to get effective purification process,  to mask unpleasant taste and odor, to protect sensitive phytochemicals from biological (e.g. enzyme, pH) and environmental (e.g. light, temperature, humidity) degradation, to control release of encapsulated phytochemicals, and to provide a more flexible control over the size and shape of the NPs. This review is focused on plant extract loaded NPs including its advantages, stages for developing formulation of plant extract loaded NPs, and nanosystem used to loading plant extract. In addition, this review also depicts studies which have been conducted by many researchers in developing plant extract loaded NPs. The data were collected from published journals with 21 and 39 journals as primary and supporting literatures, respectively. Plant extracts loaded NPs could be a promising delivery system for active phytochemical contained in the plant extract which is not only to deliver them safely but also to enhance its therapeutic efficacy.Keywords: plant, extract, nanoparticle

scholarly journals Novel strategy for the formulation of poorly water-soluble drugs: Nystatin microencapsulation.

2020 ◽  
Author(s):  
Noelia Pérez González ◽  
María Martín Villena ◽  
Ana Calpena Campmany ◽  
José Morales Molina ◽  
Beatriz Clares Naveros
Keyword(s):  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Novel Strategy

EFFECT OF CROSSLINKER AMOUNT ON HYBRID HYDROGELS SWELLING AND DRUG RELEASE

2021 ◽  
Author(s):  
Maja Markovic ◽  
◽  
Vesna Panic ◽  
Julijana Tadic ◽  
Rada Pjanovic
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Water Soluble ◽  
Soluble Model ◽  
Hybrid Hydrogels ◽  
Poorly Water Soluble ◽  
Targeted Drug ◽  
Model Drug

Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly water- soluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances.

scholarly journals Slow-targeted release of a ruthenium anticancer agent from vitamin B12 functionalized marine diatom microalgae

2018 ◽  
Vol 47 (48) ◽  
pp. 17221-17232 ◽  
Author(s):  
Joachim Delasoie ◽  
Jérémie Rossier ◽  
Laetitia Haeni ◽  
Barbara Rothen-Rutishauser ◽  
Fabio Zobi
Keyword(s):  
Vitamin B12 ◽  
Cell Lines ◽  
Targeted Delivery ◽  
Anticancer Agent ◽  
Release Profile ◽  
Water Soluble ◽  
Marine Diatom ◽  
Vitamin B ◽  
Poorly Water Soluble ◽  
Targeted Release

Bio-inspired drug capsules: The synthesis of a new vitamin-B12 modified biomaterial with increased static adherence properties toward cancer cell lines, allowed the targeted delivery of a poorly water-soluble ruthenium drug with an unprecedented release profile.

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