Tunable mechanical properties of core‐shell polymers of poly(hexyl methacrylate) and poly(methyl methacrylate) by semicontinuous heterophase polymerization

2018 ◽  
Vol 59 (2) ◽  
pp. 365-371 ◽  
Author(s):  
L. O. Sahagún Aguilar ◽  
I. Ceja Andrade ◽  
A. G. Alvarado Mendoza ◽  
J. E. Puig Arevalo ◽  
M. Rabelero Velasco
Keyword(s):  
Mechanical Properties ◽  
Methyl Methacrylate ◽  
Core Shell ◽  
Poly Methyl Methacrylate ◽  
Heterophase Polymerization ◽  
Hexyl Methacrylate ◽  
Tunable Mechanical Properties ◽  
Semicontinuous Heterophase Polymerization

SEMICONTINUOUS HETEROPHASE POLYMERIZATION AS A TOOL FOR PREPARING ULTRAFINE NANOPARTICLES OF IBUPROFEN-POLY(METHYL METHACRYLATE)

NANO ◽  
2014 ◽  
Vol 09 (06) ◽  
pp. 1450060 ◽  
Author(s):  
HENED SAADE ◽  
JESUS CEPEDA GARZA ◽  
MARIA LUISA LOPEZ-QUINTANILLA ◽  
FRANCISCO ENRIQUEZ-MEDRANO ◽  
SALVADOR FERNANDEZ ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Average Diameter ◽  
Scanning Calorimetry ◽  
Poly Methyl Methacrylate ◽  
Heterophase Polymerization ◽  
Hydrophobic Polymers ◽  
Scanning Transmission ◽  
Insoluble Drugs ◽  
20 Nm ◽  
Semicontinuous Heterophase Polymerization

Ibuprofen-loaded poly(methyl methacrylate) nanoparticles with mean diameters smaller than 20 nm were prepared by a novel method. This consists in carrying out a semicontinuous heterophase polymerization, in which a solution of drug-monomer is added on a micellar solution at an appropriate dosing rate. Scanning transmission electron microscopy (STEM) measurements showed number-average diameters in the range 16–19 nm with 1.14–1.15 in polydispersity, determined as the ratio of weight-average to number-average diameter. Drug contents in nanoparticles close to 24% were determined by UV-Vis spectrophotometry, confirming the results obtained from a procedure that combines latex filtration and quasielastic light scattering (QLS) measurements. Differential scanning calorimetry (CDSC) determinations suggest that at the ibuprofen contents attained in this study, crystals and dispersed molecules of the drug coexist inside the nanoparticles. Based on the relative simplicity of the process it is expected that its use will be adopted to prepare ultrafine nanoparticles composed of different hydrophobic polymers and water insoluble drugs.

Narrow size-distribution poly(methyl methacrylate) nanoparticles made by semicontinuous heterophase polymerization

2010 ◽  
Vol 119 (3) ◽  
pp. 1827-1834 ◽  
Author(s):  
J. Aguilar ◽  
M. Rabelero ◽  
S. M. Nuño-Donlucas ◽  
E. Mendizábal ◽  
A. Martínez-Richa ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Size Distribution ◽  
Narrow Size Distribution ◽  
Poly Methyl Methacrylate ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization
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