Narrow size-distribution poly(methyl methacrylate) nanoparticles made by semicontinuous heterophase polymerization

2010 ◽  
Vol 119 (3) ◽  
pp. 1827-1834 ◽  
Author(s):  
J. Aguilar ◽  
M. Rabelero ◽  
S. M. Nuño-Donlucas ◽  
E. Mendizábal ◽  
A. Martínez-Richa ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Size Distribution ◽  
Narrow Size Distribution ◽  
Poly Methyl Methacrylate ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Semicontinuous heterophase polymerization under monomer starved conditions to prepare nanoparticles with narrow size distribution

2007 ◽  
Vol 45 (8) ◽  
pp. 1463-1473 ◽  
Author(s):  
Raquel Ledezma ◽  
M. Esther Treviño ◽  
Luis E. Elizalde ◽  
Lourdes A. Pérez-Carrillo ◽  
Eduardo Mendizábal ◽  
...  
Keyword(s):  
Size Distribution ◽  
Narrow Size Distribution ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

SEMICONTINUOUS HETEROPHASE POLYMERIZATION AS A TOOL FOR PREPARING ULTRAFINE NANOPARTICLES OF IBUPROFEN-POLY(METHYL METHACRYLATE)

NANO ◽  
2014 ◽  
Vol 09 (06) ◽  
pp. 1450060 ◽  
Author(s):  
HENED SAADE ◽  
JESUS CEPEDA GARZA ◽  
MARIA LUISA LOPEZ-QUINTANILLA ◽  
FRANCISCO ENRIQUEZ-MEDRANO ◽  
SALVADOR FERNANDEZ ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Average Diameter ◽  
Scanning Calorimetry ◽  
Poly Methyl Methacrylate ◽  
Heterophase Polymerization ◽  
Hydrophobic Polymers ◽  
Scanning Transmission ◽  
Insoluble Drugs ◽  
20 Nm ◽  
Semicontinuous Heterophase Polymerization

Ibuprofen-loaded poly(methyl methacrylate) nanoparticles with mean diameters smaller than 20 nm were prepared by a novel method. This consists in carrying out a semicontinuous heterophase polymerization, in which a solution of drug-monomer is added on a micellar solution at an appropriate dosing rate. Scanning transmission electron microscopy (STEM) measurements showed number-average diameters in the range 16–19 nm with 1.14–1.15 in polydispersity, determined as the ratio of weight-average to number-average diameter. Drug contents in nanoparticles close to 24% were determined by UV-Vis spectrophotometry, confirming the results obtained from a procedure that combines latex filtration and quasielastic light scattering (QLS) measurements. Differential scanning calorimetry (CDSC) determinations suggest that at the ibuprofen contents attained in this study, crystals and dispersed molecules of the drug coexist inside the nanoparticles. Based on the relative simplicity of the process it is expected that its use will be adopted to prepare ultrafine nanoparticles composed of different hydrophobic polymers and water insoluble drugs.

Investigation of free volume characteristics of the interfacial layer in poly(methyl methacrylate)–alumina nanocomposite and its role in thermal behaviour

RSC Advances ◽  
2016 ◽  
Vol 6 (72) ◽  
pp. 67997-68004 ◽  
Author(s):  
S. K. Sharma ◽  
K. Sudarshan ◽  
M. Sahu ◽  
P. K. Pujari
Keyword(s):  
Methyl Methacrylate ◽  
Size Distribution ◽  
Free Volume ◽  
Thermal Behaviour ◽  
Interfacial Layer ◽  
Poly Methyl Methacrylate ◽  
Alumina Particles ◽  
Alumina Composites ◽  
Volume Characteristics

A denser interfacial layer with smaller size nanoholes and narrower size distribution around alumina particles in PMMA–alumina composites.

Preparation and Properties of Chitosan Graft Copolymer Nanoparticles Using Potassium Diperiоdatоnickelate

2014 ◽  
Vol 924 ◽  
pp. 61-64
Author(s):  
Zhan Jun Liu ◽  
Ming Fei Zhao ◽  
Zhen Gang Wu ◽  
Gang Han
Keyword(s):  
Methyl Methacrylate ◽  
Graft Copolymer ◽  
Burst Release ◽  
Narrow Size Distribution ◽  
Natural Polymer ◽  
Poly Methyl Methacrylate ◽  
Transmission Electron ◽  
Covalently Linked ◽  
Process Method

Nanoparticles comprising chitosan-graft-poly (methyl methacrylate) (CS-g-PMMA) copolymer were successfully synthesized in aqueous solution by using potassium diperiоdatоnickelate (Ni (IV)) as an initiator. The nanoparticles were characterized in terms of Fourier transform infrared (FTIR), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results indicated that chitosan was covalently linked to poly (methyl methacrylate) (PMMA) and the particles were uniform, spherical and well dispersed with narrow size distribution. Paclitaxel-loaded nanoparticles were prepared and in vitro release showed that these nanoparticles provided an initial burst release followed by a slowly sustained release for more than 16 days. Therefore, this process method would be used for synthesizing natural polymer graft copolymer nanoparticles with wide prospect.

Sign in / Sign up

Export Citation Format

Share Document