A bioresorbable cardiovascular stent prepared from L -lactide, trimethylene carbonate and glycolide terpolymers

2013 ◽  
Vol 54 (6) ◽  
pp. 1418-1426 ◽  
Author(s):  
Jianting Dong ◽  
Lan Liao ◽  
Li Shi ◽  
Zaishang Tan ◽  
Zhongyong Fan ◽  
...  
Keyword(s):  
Trimethylene Carbonate ◽  
Cardiovascular Stent

Current Concepts on Cardiovascular Stent Devices

2014 ◽  
Vol 14 (6) ◽  
pp. 505-536 ◽  
Author(s):  
I. Neamtu ◽  
A.P. Chiriac ◽  
A. Diaconu ◽  
L.E. Nita ◽  
V. Balan ◽  
...  
Keyword(s):  
Cardiovascular Stent

scholarly journals Mechanochemical synthesis of poly(trimethylene carbonate)s: an example of rate acceleration

2019 ◽  
Vol 15 ◽  
pp. 963-970 ◽  
Author(s):  
Sora Park ◽  
Jeung Gon Kim
Keyword(s):  
Ball Milling ◽  
Mechanochemical Synthesis ◽  
Polymeric Materials ◽  
Solvent Free ◽  
Energy Output ◽  
Polymerization Temperature ◽  
Mechanical Degradation ◽  
Trimethylene Carbonate ◽  
Rate Acceleration ◽  
Conventional Solution

Mechanochemical polymerization is a rapidly growing area and a number of polymeric materials can now be obtained through green mechanochemical synthesis. In addition to the general merits of mechanochemistry, such as being solvent-free and resulting in high conversions, we herein explore rate acceleration under ball-milling conditions while the conventional solution-state synthesis suffer from low reactivity. The solvent-free mechanochemical polymerization of trimethylene carbonate using the organocatalysts 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) are examined herein. The polymerizations under ball-milling conditions exhibited significant rate enhancements compared to polymerizations in solution. A number of milling parameters were evaluated for the ball-milling polymerization. Temperature increases due to ball collisions and exothermic energy output did not affect the polymerization rate significantly and the initial mixing speed was important for chain-length control. Liquid-assisted grinding was applied for the synthesis of high molecular weight polymers, but it failed to protect the polymer chain from mechanical degradation.

Biodegradable cross‐linked poly(1,3‐trimethylene carbonate) networks formed by gamma irradiation under vacuum

2021 ◽  
Author(s):  
Xiliang Liu ◽  
Song Liu ◽  
Shaomin Feng ◽  
Kaiqi Li ◽  
Youkun Fan ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Trimethylene Carbonate

scholarly journals Photoprintable Gelatin-graft-Poly(trimethylene carbonate) by Stereolithography for Tissue Engineering Applications

2021 ◽  
Author(s):  
Thomas Brossier ◽  
Gael Volpi ◽  
Jonaz Vasquez-Villegas ◽  
Noémie Petitjean ◽  
Olivier Guillaume ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Trimethylene Carbonate ◽  
Engineering Applications

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

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