Synthesis and characterization of novel poly(butylene succinate)-based copolyesters designed as potential candidates for soft tissue engineering

2012 ◽  
Vol 53 (3) ◽  
pp. 491-501 ◽  
Author(s):  
Matteo Gigli ◽  
Nadia Lotti ◽  
Massimo Gazzano ◽  
Lara Finelli ◽  
Andrea Munari
2016 ◽  
Vol 4 (11) ◽  
pp. 1682-1690 ◽  
Author(s):  
Hongye Hao ◽  
Jingyu Shao ◽  
Ya Deng ◽  
Shan He ◽  
Feng Luo ◽  
...  

Light-crosslinking waterborne polyurethanes (LWPUs) based on lysine possess appropriate elasticity for soft tissue repair, and can induce macrophages into a wound healing phenotype.


RSC Advances ◽  
2016 ◽  
Vol 6 (37) ◽  
pp. 30862-30866 ◽  
Author(s):  
Haiyan Wu ◽  
Huifeng Wang ◽  
Fang Cheng ◽  
Fujian Xu ◽  
Gang Cheng

A matrix metalloproteinase peptide cross-linked dextran hydrogel was synthesized. Dextran was modified with carboxybetaine to resist nonspecific protein adsorption and cell attachment. The degradable hydrogel is a good candidate for soft tissue engineering applications.


Author(s):  
Yi Zhang ◽  
Richard T. Tran ◽  
Dipendra Gyawali ◽  
Jian Yang

Finding an ideal biomaterial with the proper mechanical properties and biocompatibility has been of intense focus in the field of soft tissue engineering. This paper reports on the synthesis and characterization of a novel crosslinked urethane-doped polyester elastomer (CUPOMC), which was synthesized by reacting a previously developed photocrosslinkable poly (octamethylene maleate citrate) (POMC) prepolymers (pre-POMC) with 1,6-hexamethylene diisocyanate (HDI) followed by thermo- or photo-crosslinking polymerization. The mechanical properties of the CUPOMCs can be tuned by controlling the molar ratios of pre-POMC monomers, and the ratio between the prepolymer and HDI. CUPOMCs can be crosslinked into a 3D network through polycondensation or free radical polymerization reactions. The tensile strength and elongation at break of CUPOMC synthesized under the known conditions range from 0.73±0.12MPa to 10.91±0.64MPa and from 72.91±9.09% to 300.41±21.99% respectively. Preliminary biocompatibility tests demonstrated that CUPOMCs support cell adhesion and proliferation. Unlike the pre-polymers of other crosslinked elastomers, CUPOMC pre-polymers possess great processability demonstrated by scaffold fabrication via a thermally induced phase separation method. The dual crosslinking methods for CUPOMC pre-polymers should enhance the versatile processability of the CUPOMC used in various conditions. Development of CUPOMC should expand the choices of available biodegradable elastomers for various biomedical applications such as soft tissue engineering.


2016 ◽  
Vol 51 (18) ◽  
pp. 8361-8381 ◽  
Author(s):  
Ehsan Fallahiarezoudar ◽  
Mohaddeseh Ahmadipourroudposht ◽  
Ani Idris ◽  
Noordin Mohd Yusof ◽  
Mohsen Marvibaigi ◽  
...  

Author(s):  
Loretta L. del Mercato ◽  
Laura Gioia Passione ◽  
Daniela Izzo ◽  
Rosaria Rinaldi ◽  
Alessandro Sannino ◽  
...  

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