scholarly journals The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study

2021 ◽  
Vol 5 (1) ◽  
pp. 21-27
Author(s):  
Yinkun Yan ◽  
Shengxu Li ◽  
Yang Liu ◽  
Lydia Bazzano ◽  
Jiang He ◽  
...  
Keyword(s):  
Body Weight ◽  
Chronic Inflammation ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
The Impact

scholarly journals Black–White Difference in the Impact of Long-Term Blood Pressure From Childhood on Adult Renal Function: The Bogalusa Heart Study

2018 ◽  
Vol 31 (12) ◽  
pp. 1300-1306 ◽  
Author(s):  
Yinkun Yan ◽  
Tao Zhang ◽  
Shengxu Li ◽  
Yang Liu ◽  
Lydia Bazzano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
The Impact

scholarly journals Suppression effect of body weight on the association between cigarette smoking and telomere length: the Bogalusa Heart Study

Aging ◽  
2019 ◽  
Vol 11 (21) ◽  
pp. 9893-9900
Author(s):  
Miaoying Yun ◽  
Shengxu Li ◽  
Yinkun Yan ◽  
Tao Zhang ◽  
Lydia Bazzano ◽  
...  
Keyword(s):  
Body Weight ◽  
Cigarette Smoking ◽  
Telomere Length ◽  
Bogalusa Heart Study ◽  
Suppression Effect ◽  
Heart Study

Serum apolipoproteins A-I and B as markers of coronary artery disease risk in early life: the Bogalusa Heart Study

1995 ◽  
Vol 41 (1) ◽  
pp. 159-164 ◽  
Author(s):  
S R Srinivasan ◽  
G S Berenson
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Coronary Artery Disease Risk ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
Artery Disease ◽  
The Impact

Abstract The functional properties of the apolipoproteins (apoB and apoA-I) governing lipoprotein metabolism make these variables conceptually important as markers for coronary artery disease risk. This aspect was examined in a biracial (black-white) population of children as part of the Bogalusa Heart Study. White children, especially boys, showed lower concentrations of apoA-I and ratios of cholesterol to apoB within low-density lipoprotein (LDL) than did black children. Persistence of apoB concentrations over time, coupled with its strong linkage with apoB gene locus, underscores the value of detecting apoB excess early in life. Further, the impact of apoE genotypes on apoB and apoA-I levels is already evident in childhood. We found that, as a screening test for detecting increased LDL cholesterol, apoB is superior to total cholesterol. Low values for apoA-I concentration, the apoA-I to apoB ratio, and LDL cholesterol to apoB ratio in children are strongly related to parental incidence of myocardial infarction; no such relationship is seen with respect to lipoprotein cholesterols. Thus, expanding screening strategies might be useful for identifying individuals with adverse apolipoprotein profiles early in life.

Abstract P371: Race Disparities in the Contribution of Lipid Profiles to Ankle-Brachial Index: Lifecourse Evidence from the Bogalusa Heart Study

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Camilo Fernandez ◽  
Liqiang Zheng ◽  
Yajun Guo ◽  
Rupert Barshop ◽  
Emily Harville ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ankle Brachial Index ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Regression Analyses ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
The Impact

Background: Ankle-brachial index (ABI) is a practical non-invasive estimation of the burden of atherosclerosis on the vascular system. Although cholesterol is known to affect ABI as part of the disease process, information is limited on the contribution of longitudinal measures of cholesterol on the decline of ABI over time. Hypothesis: Race (black-white)—specific differences exist in cumulative burden effects of cholesterol, measured from childhood to adulthood, on ABI decline in young adults. Methods: We examined 497 adult participants of the Bogalusa Heart Study (72.8% white, 43.1% men, age 32-51 years), who had at least 3 measurements of cardiovascular (CV) risk factors since childhood (average follow-up 33.5 years). ABI was obtained in two separate instances: baseline (2001-2002) and follow-up (2007-2010), and its change was computed as the mean difference, divided by the time (years), between the two instances. The long-term cumulative burden of each risk factor was calculated as the total area under the curve (AUCt). Measurements of cholesterol and other CV risk factors in childhood, adulthood and AUCt were standardized to z-scores prior to regression analyses. Results: ABI significantly decreased (1.09±0.09 vs 1.03±0.09, p<0.01) after a mean follow-up of 6.8 years. There were no significant differences in annual ABI decline between male and female (p=0.56) / black and white (p=0.18) participants. In multivariable linear regression analyses, after adjustment for sex, lipid-lowering medications, smoking status, body mass index, systolic blood pressure and baseline ABI, significant predictors of annual ABI decline in white participants were: childhood total cholesterol (TC) (β= -0.11, p<0.01), low-density lipoprotein cholesterol (LDL-C; β= -0.10; p<0.01), and non-high-density lipoprotein cholesterol (non-HDL-C; β= -0.10, p<0.01), as well as the AUCt of TC (β= -0.09; p=0.02) and non-HDL-C (β= -0.08, p=0.04). The AUCt of HDL-C was the only significant predictor in black participants (β= 0.16, p=0.04). Conclusions: These findings suggest that the impact of cholesterol levels on future adult ABI decline starts in childhood, and follows a cumulative detrimental pattern throughout the lifespan in a race-dependent fashion. Further, this information may aid in the development of strategies to improve prevention, diagnosis and treatment of vascular disease by race group

Life-Course Glucose Trajectory and Cognitive Function in Middle Age—Evidence from the Bogalusa Heart Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1474-P
Author(s):  
PATRICK STUCHLIK ◽  
OWEN CARMICHAEL ◽  
EMILY HARVILLE ◽  
HUA HE ◽  
MARYELLEN ROMERO ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Life Course ◽  
Middle Age ◽  
Bogalusa Heart Study ◽  
Heart Study
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