scholarly journals Brain development in children with developmental delay using amide proton transfer‐weighted imaging and magnetization transfer imaging

2020 ◽  
Vol 4 (4) ◽  
pp. 250-256
Author(s):  
Xiaolu Tang ◽  
Hong Zhang ◽  
Jinyuan Zhou ◽  
Huiying Kang ◽  
Shuangfeng Yang ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Brain Development ◽  
Developmental Delay ◽  
Magnetization Transfer ◽  
Amide Proton ◽  
Magnetization Transfer Imaging ◽  
Amide Proton Transfer

scholarly journals Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development

2016 ◽  
Vol 26 (10) ◽  
pp. 3368-3376 ◽  
Author(s):  
Hong Zhang ◽  
Huiying Kang ◽  
Xuna Zhao ◽  
Shanshan Jiang ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Proton Transfer ◽  
Brain Development ◽  
Magnetization Transfer ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Pediatric Brain

scholarly journals Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yang Zheng ◽  
Xiaoming Wang ◽  
Xuna Zhao
Keyword(s):  
Basal Ganglia ◽  
Proton Transfer ◽  
Brain Development ◽  
Gestational Age ◽  
Magnetization Transfer ◽  
Occipital Lobe ◽  
Brain Regions ◽  
Amide Proton ◽  
Neonatal Brain ◽  
Neonatal Brain Development

Purpose.This study aims to evaluate the process of brain development in neonates using combined amide proton transfer (APT) imaging and conventional magnetization transfer (MT) imaging.Materials and Methods.Case data were reviewed for all patients hospitalized in our institution’s neonatal ward. Patients underwent APT and MT imaging (a single protocol) immediately following the routine MR examination. Single-slice APT/MT axial imaging was performed at the level of the basal ganglia. APT and MT ratio (MTR) measurements were performed in multiple brain regions of interest (ROIs). Data was statistically analyzed in order to assess for significant differences between the different regions of the brain or correlation with patient gestational age.Results.A total of 38 neonates were included in the study, with ages ranging from 27 to 41 weeks’ corrected gestational age. There were statistically significant differences in both APT and MTR measurements between the frontal lobes, basal ganglia, and occipital lobes (APT: frontal lobe versus occipital lobeP=0.031and other groupsP=0.00; MTR: frontal lobe versus occipital lobeP=0.034and other groupsP=0.00). Furthermore, APT and MTR in above brain regions exhibited positive linear correlations with patient gestational age.Conclusions.APT/MT imaging can provide valuable information about the process of the neonatal brain development at the molecular level.

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