Down syndrome maternal serum markers in oocyte donation and other assisted reproductive technologies

2017 ◽  
Vol 37 (11) ◽  
pp. 1155-1159 ◽  
Author(s):  
Aurore Bonnin ◽  
Françoise Muller ◽  
Marie-Victoire Senat ◽  
Corinne Sault ◽  
Armelle Galland ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Oocyte Donation ◽  
Serum Markers ◽  
Maternal Serum

scholarly journals Evaluating the Agreement of Risk Categorization for Fetal Down Syndrome Screening between Ultrasound-Based Gestational Age and Menstrual-Based Gestational Age by Maternal Serum Markers

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Pakorn Chaksuwat ◽  
Supatra Sirichotiyakul ◽  
Suchaya Luewan ◽  
Theera Tongsong
Keyword(s):  
Down Syndrome ◽  
Gestational Age ◽  
False Positive Rate ◽  
Serum Markers ◽  
Maternal Serum ◽  
Menstrual Period ◽  
Last Menstrual Period ◽  
Second Trimester Screening ◽  
Risk Categorization ◽  
Down Syndrome Screening

Objective. To evaluate the agreement of risk categorization for Down syndrome screening between ultrasound scan-based gestational age (GA) and last menstrual period-based gestational age in both first and second trimesters by maternal serum markers. Methods. Data comprising 4,055 and 4,016 cases of first and second trimester screening were used. The maternal serum markers were analyzed using the ultrasound-based GA and menstrual age. The subjects whose menstrual age and ultrasound-based GA fell in different trimesters were excluded because the risk could not be calculated due to the different serum markers used in each trimester. The agreement of risk categorization for fetal Down syndrome was evaluated. Results. The agreement of Down syndrome screening in the first and the second trimesters were 92.7% and 89%, respectively. The study found a good agreement of risk categorization by Kappa index, which was 0.615 for the overall screening. The menstrual age had a slight decrease in the detection rate and a lower false-positive rate. Conclusion. Menstrual age is acceptable in cases of accurate last menstrual period. However, in places where ultrasonography is not readily available, gestational age estimation by menstrual age along with clinical examination that corresponds to the gestational age can be reliable.

Oocyte Donation Does Not Influence Adversely the Outcome of Assisted Reproductive Technologies

2005 ◽  
Vol 84 ◽  
pp. S244 ◽  
Author(s):  
D.H. Mendes-Pereira ◽  
E. Cavalcante ◽  
E. Catafesta ◽  
L. Shimabukuro ◽  
M.C. Cury ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Oocyte Donation

scholarly journals Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples

2004 ◽  
Vol 50 (1) ◽  
pp. 182-189 ◽  
Author(s):  
Glenn E Palomaki ◽  
George J Knight ◽  
Marie M Roberson ◽  
George C Cunningham ◽  
Jo Ellen Lee ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Observational Study ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
False Positive Rate ◽  
Serum Markers ◽  
Maternal Serum ◽  
Second Trimester ◽  
Preliminary Results ◽  
Hyperglycosylated Human Chorionic Gonadotropin

Abstract Background: Down syndrome screening is commonly performed in the US using maternal age and three or four second-trimester maternal serum markers that can identify up to 75% of affected pregnancies by offering diagnostic studies to 5% of women. Invasive trophoblast antigen [ITA; hyperglycosylated human chorionic gonadotropin (hCG)] is a promising marker that can be measured in urine or serum in the first or second trimester. We report preliminary results for urinary ITA in an ongoing observational study. Methods: Women undergoing second-trimester amniocentesis for reasons not associated with biochemical testing provided consent and a urine (and possibly serum) sample that was tested within a few days. Demographic and pregnancy-related information was collected, along with karyotype. Screening performance was modeled for ITA alone and in combination with serum markers Results: Twelve recruitment centers collected urine from 2055 women with singleton pregnancies between 15 and 20 weeks of gestation (2023 unaffected, 28 Down syndrome, and 4 pregnancies with other chromosome abnormalities). After correction for gestational age, urine concentration, and maternal race and weight, the ITA measurements were higher in women with a Down syndrome pregnancy (median ITA, 4.33 multiples of the median). At a 75% detection rate, the false-positive rate could be reduced by substituting ITA for hCG measurements (from 5.6% to 2.6% for the triple test) or by adding ITA measurements to existing combinations (from 3.3% to 2.0% for the quadruple test). Conclusions: Our data provide preliminary confirmation of the potential usefulness of urinary ITA measurements in detecting Down syndrome in a setting that simulates routine usage.

LETTER TO THE EDITOR. ETHNIC ORIGIN AND MATERNAL SERUM MARKERS OF DOWN SYNDROME IN ISRAEL

1996 ◽  
Vol 16 (9) ◽  
pp. 870-872 ◽  
Author(s):  
G. BARKAI ◽  
B. GOLDMAN ◽  
L. RIES ◽  
R. CHAKI ◽  
H. S. CUCKLE
Keyword(s):  
Down Syndrome ◽  
Ethnic Origin ◽  
Serum Markers ◽  
Maternal Serum ◽  
Letter To The Editor

Role of prenatal ultrasonography in women with positive screen for Down syndrome on the basis of maternal serum markers

1995 ◽  
Vol 173 (4) ◽  
pp. 1030-1035 ◽  
Author(s):  
David A. Nyberg ◽  
David A. Luthy ◽  
Edith Y. Cheng ◽  
Robert C. Sheley ◽  
Robert G. Resta ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Serum Markers ◽  
Maternal Serum ◽  
Prenatal Ultrasonography ◽  
Positive Screen

Risk of amniocentesis in women screened positive for Down syndrome with second trimester maternal serum markers

2002 ◽  
Vol 22 (11) ◽  
pp. 1036-1039 ◽  
Author(s):  
Françoise Muller ◽  
Didier Thibaud ◽  
Françoise Poloce ◽  
Marie-Christine Gelineau ◽  
Marguerite Bernard ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Serum Markers ◽  
Maternal Serum ◽  
Second Trimester
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