Clinical applications of 3D volume MR imaging of the fetal brain in utero

2017 ◽  
Vol 37 (6) ◽  
pp. 556-565 ◽  
Author(s):  
Deborah Jarvis ◽  
Paul D. Griffiths
Keyword(s):  
Mr Imaging ◽  
Fetal Brain ◽  
In Utero ◽  
Clinical Applications ◽  
3D Volume

scholarly journals Normative volume measurements of the fetal intra-cranial compartments using 3D volume in utero MR imaging

2019 ◽  
Vol 29 (7) ◽  
pp. 3488-3495 ◽  
Author(s):  
Deborah A. Jarvis ◽  
Chloe R. Finney ◽  
Paul D. Griffiths
Keyword(s):  
Mr Imaging ◽  
In Utero ◽  
Volume Measurements ◽  
3D Volume

Predicting neurodevelopmental outcomes in fetuses with isolated mild ventriculomegaly

2021 ◽  
pp. fetalneonatal-2021-321984
Author(s):  
Paul David Griffiths ◽  
Deborah Jarvis ◽  
Daniel J Connolly ◽  
Cara Mooney ◽  
Nicholas Embleton ◽  
...  
Keyword(s):  
Neurodevelopmental Outcome ◽  
Fetal Brain ◽  
In Utero ◽  
Neurodevelopmental Outcomes ◽  
Volume Imaging ◽  
Fetal Ventriculomegaly ◽  
3D Volume ◽  
Very High ◽  
High Chance ◽  
Neurodevelopment Outcome

BackgroundFetal ventriculomegaly is the the most common intracranial abnormality detected antenatally. When ventriculomegaly is mild and the only, isolated, abnormality detected (isolated mild ventriculomegaly (IMVM)) the prognosis is generally considered to be good. We aim to determine if there are features on in utero MRI (iuMRI) that can identify fetuses with IMVM who have lower risks of abnormal neurodevelopment outcome.MethodsWe studied cases recruited into the MRI to enhance the diagnosis of fetal developmental brain abnormalities in utero (MERIDIAN) study, specifically those with: confirmed IMVM, 3D volume imaging of the fetal brain and neurodevelopmental outcomes at 3 years. We explored the influence of sex of the fetus, laterality of the ventriculomegaly and intracranial compartmental volumes in relation to neurodevelopmental outcome.FindingsForty-two fetuses met the criteria (33 male and 9 female). There was no obvious correlation between fetal sex and the risk of poor neurodevelopmental outcome. Unilateral IMVM was present in 23 fetuses and bilateral IMVM in 19 fetuses. All fetuses with unilateral IMVM had normal neurodevelopmental outcomes, while only 12/19 with bilateral IMVM had normal neurodevelopmental outcomes. There was no obvious correlation between measure of intracranial volumes and risk of abnormal developmental outcomes.InterpretationThe most important finding is the very high chance of a good neurodevelopmental outcome observed in fetuses with unilateral IMVM, which is a potentially important finding for antenatal counselling. There does not appear to be a link between the volume of the ventricular system or brain volume and the risk of poor neurodevelopmental outcome.

scholarly journals Quantification of total fetal brain volume using 3D MR imaging data acquired in utero

2016 ◽  
Vol 36 (13) ◽  
pp. 1225-1232 ◽  
Author(s):  
Deborah Jarvis ◽  
Rahim Akram ◽  
Laura Mandefield ◽  
Michael Paddock ◽  
Paul Armitage ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Brain Volume ◽  
Fetal Brain ◽  
In Utero ◽  
Imaging Data ◽  
3D Mr Imaging

scholarly journals Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes

2021 ◽  
Author(s):  
Rachel L. Leon ◽  
Imran N. Mir ◽  
Christina L. Herrera ◽  
Kavita Sharma ◽  
Catherine Y. Spong ◽  
...  
Keyword(s):  
Brain Development ◽  
Congenital Heart ◽  
Fetal Brain ◽  
In Utero ◽  
Structure And Function ◽  
Brain Growth ◽  
Neurodevelopmental Outcomes ◽  
Fetal Brain Development ◽  
And Function

Abstract Children with congenital heart disease (CHD) are living longer due to effective medical and surgical management. However, the majority have neurodevelopmental delays or disorders. The role of the placenta in fetal brain development is unclear and is the focus of an emerging field known as neuroplacentology. In this review, we summarize neurodevelopmental outcomes in CHD and their brain imaging correlates both in utero and postnatally. We review differences in the structure and function of the placenta in pregnancies complicated by fetal CHD and introduce the concept of a placental inefficiency phenotype that occurs in severe forms of fetal CHD, characterized by a myriad of pathologies. We propose that in CHD placental dysfunction contributes to decreased fetal cerebral oxygen delivery resulting in poor brain growth, brain abnormalities, and impaired neurodevelopment. We conclude the review with key areas for future research in neuroplacentology in the fetal CHD population, including (1) differences in structure and function of the CHD placenta, (2) modifiable and nonmodifiable factors that impact the hemodynamic balance between placental and cerebral circulations, (3) interventions to improve placental function and protect brain development in utero, and (4) the role of genetic and epigenetic influences on the placenta–heart–brain connection. Impact Neuroplacentology seeks to understand placental connections to fetal brain development. In fetuses with CHD, brain growth abnormalities begin in utero. Placental microstructure as well as perfusion and function are abnormal in fetal CHD.

Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: Basic principles and clinical applications

1996 ◽  
Vol 6 (2) ◽  
pp. 311-321 ◽  
Author(s):  
Koenraad L. Verstraete ◽  
Henk-Jan Van der Woude ◽  
Pancras C. W. Hogendoorn ◽  
Yves De Deene ◽  
Marc Kunnen ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Clinical Applications ◽  
Basic Principles ◽  
Musculoskeletal Tumors ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Fetal brain development of twins assessed in utero by ultrasound: implications for schizophrenia

1996 ◽  
Vol 19 (2-3) ◽  
pp. 141-149 ◽  
Author(s):  
John H. Gilmore ◽  
Diana O. Perkins ◽  
Mark A. Kliewer ◽  
Marvin L. Hage ◽  
Susan G. Silva ◽  
...  
Keyword(s):  
Brain Development ◽  
Fetal Brain ◽  
In Utero ◽  
Fetal Brain Development

Magnetic resonance imaging versus ultrasonography for the in utero evaluation of central nervous system anomalies

2010 ◽  
Vol 6 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Pierpaolo Peruzzi ◽  
Rebecca J. Corbitt ◽  
Corey Raffel
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prenatal Diagnosis ◽  
Mr Imaging ◽  
False Negative ◽  
In Utero ◽  
Resonance Imaging ◽  
Fetal Ultrasonography ◽  
Negative Results ◽  
False Negative Results ◽  
Fetal Mr

Object The use of fetal MR imaging for the in utero evaluation of pathological conditions of the CNS is widely accepted as an adjunct to fetal ultrasonography studies. Magnetic resonance imaging is thought to characterize CNS anomalies better, and to provide a more exact diagnosis and accurate prognosis. The purpose of this study was to determine the role of and indications for fetal MR imaging in evaluating fetuses with different CNS abnormalities that were seen initially on prenatal sonograms. Methods Over a 3-year period, fetuses with prior sonographic evidence of CNS abnormalities who consequently received prenatal MR imaging at Columbus Nationwide Children's Hospital within 2 weeks of the fetal ultrasonography study were included in this study. For each patient, radiological reports from both studies were reviewed, analyzed, and compared with the findings at postnatal imaging or physical examination. Results of the 2 modalities were then compared in terms of diagnostic accuracy. Results Twenty-six fetuses were included in this study on the basis of an in utero sonogram showing a CNS anomaly. Their gestational age ranged from 17 to 35 weeks, with a mean of 25 weeks at the time of fetal ultrasonography. Hydrocephalus was identified in 16 fetuses, 6 had evidence of a spinal dysraphic defect, 2 had holoprosencephaly, 1 had an encephalocele, and 1 had multiple body abnormalities requiring detailed CNS evaluation. Twenty-five of the fetuses were correctly evaluated as having abnormal CNS findings on both fetal ultrasonography and fetal MR imaging. Fetal ultrasonography provided a correct prenatal diagnosis in 20 cases, whereas fetal MR imaging was correct in 22 cases. There were 9 cumulative false-positive results for fetal ultrasonography and 7 for fetal MR imaging, whereas for false-negative results there were a total of 34 and 19, respectively. Conclusions Fetal MR imaging is more sensitive in detecting fetal CNS abnormalities, but its ability to provide a correct prenatal diagnosis is only marginally superior to fetal ultrasonography. Moreover, fetal MR imaging is not exempt from misdiagnosis, and still shows a significantly high rate of false-negative results. Particularly for spinal dysraphic defects, fetal MR imaging does not seem to add important diagnostic or prognostic details when compared with fetal ultrasonography.

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