Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis

2015 ◽  
Vol 35 (8) ◽  
pp. 725-734 ◽  
Author(s):  
Peter Benn ◽  
Antoni Borrell ◽  
Rossa W. K. Chiu ◽  
Howard Cuckle ◽  
Lorraine Dugoff ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
International Society ◽  
Chromosome Abnormality ◽  
Position Statement

scholarly journals Aneuploidy screening: a position statement from a committee on behalf of the Board of the International Society for Prenatal Diagnosis, January 2011

2011 ◽  
Vol 31 (6) ◽  
pp. 519-522 ◽  
Author(s):  
Peter Benn ◽  
Antoni Borrell ◽  
Jenny Crossley ◽  
Howard Cuckle ◽  
Lorraine Dugoff ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
International Society ◽  
Position Statement ◽  
Aneuploidy Screening

Position statement from the Aneuploidy Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis

2013 ◽  
Vol 33 (7) ◽  
pp. 622-629 ◽  
Author(s):  
Peter Benn ◽  
Antoni Borell ◽  
Rossa Chiu ◽  
Howard Cuckle ◽  
Lorraine Dugoff ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
International Society ◽  
Position Statement ◽  
Aneuploidy Screening

Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement

Cytotherapy ◽  
2005 ◽  
Vol 7 (5) ◽  
pp. 393-395 ◽  
Author(s):  
E.M. Horwitz ◽  
K. Le Blanc ◽  
M. Dominici ◽  
I. Mueller ◽  
I. Slaper-Cortenbach ◽  
...  
Keyword(s):  
International Society ◽  
Cellular Therapy ◽  
Position Statement

Use of Bayes' Formula to Make a Genetic Risk Estimate

2011 ◽  
Vol 14 (4) ◽  
pp. 340-342
Author(s):  
Alan Stark ◽  
Graeme Morgan
Keyword(s):  
Prenatal Diagnosis ◽  
Genetic Risk ◽  
Prior Probability ◽  
Chromosome Abnormality ◽  
Genetic Diagnosis ◽  
Risk Estimate ◽  
Bayesian Estimate ◽  
Chromosome 13 ◽  
Amount Of Information ◽  
Bayes Formula

Izabella and her partner sought pre-implantation genetic diagnosis (PGD) because Izabella had retinoblastoma due to a deletion in chromosome 13 and they want to have children not at genetic risk of retinoblastoma. Fortunately, Izabella's tumor was unilateral and was treated successfully and she is well. Izabella's chromosome abnormality is mosaic with 70% of lymphocytes having the deletion. This mosaicism may not be present in Izabella's ovaries. The couple went through PGD on two occasions and 13 embryos were tested. None had the deleted chromosome 13. IVF and PGD failed to produce a pregnancy. The couple wished to know what the experience provides as to the risk to their offspring: in particular, does it indicate a risk low enough to be acceptable if they go ahead with a natural pregnancy instead of another resort to PGD? Also, the couple did not want prenatal diagnosis. The situation therefore requires an estimate of the probability that an embryo will have the deletion. Counseling is problematic because there is no obvious way of selecting a prior probability from which to compute a Bayesian estimate of risk. Two solutions are offered, depending on the amount of information available about genes transmitted from the maternal grandparents.

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