The relationship of angiogenic factors to maternal and neonatal manifestations of early-onset and late-onset preeclampsia

2014 ◽  
Vol 34 (11) ◽  
pp. 1084-1092 ◽  
Author(s):  
Cilene Carlos Pinheiro ◽  
Patricia Rayol ◽  
Luiz Gozzani ◽  
Luciene Machado dos Reis ◽  
Gianfranco Zampieri ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Angiogenic Factors ◽  
Relationship Of ◽  
The Relationship

THE RELATIONSHIP BETWEEN THE ONSET OF SEVERE PREECLAMPSIA AND PERINATAL COMPLICATIONS AT RUMKITAL Dr. RAMELAN IN SURABAYA

2021 ◽  
Vol 5 (2) ◽  
pp. 139
Author(s):  
Widya Retno ◽  
Ivon Diah Wittiarika ◽  
Muhammad Aldika Akbar
Keyword(s):  
Preterm Delivery ◽  
Early Onset ◽  
Late Onset ◽  
Previous History ◽  
Severe Preeclampsia ◽  
P Value ◽  
Chronic Hypertension ◽  
Perinatal Complications ◽  
Exact Test ◽  
The Relationship

 Abstract Background: Preeclampsia is one of the biggest causes of maternal-fetal morbidity and mortality. Based on the prognosis, the classification of Preeclampsia is early onset (<34 weeks) and late onset (> 34 weeks). Purpose: to investigate the relationship between the onset of severe Preeclampsia and perinatal complications. Method: This research is a quantitative study with a retrospective observational analytic study type and collected medical record data. The study population was severe Preeclampsia  patients who gave birth at RUMKITAL Dr. Ramelan Surabaya for the period January 2018 - June 2020 and has no previous history of chronic hypertension. The research sample was 79 subjects with 44 subjects early onset, and 35 subjects late onset. Perinatal complications  examined are preterm delivery, asphyxia, LBW, IUGR, stillbirth. The chi-square test or Fisher’s Exact Test was used to analyze relationships. Result: From the results of the study, the comparison of the percentage from early onset and late onset that experienced complications was 93.2% vs 48.6%, p-value = 0.000, OR = 14.5, CI = 3,764–55,635.  At preterm delivery, it was found that 75% vs 28.6%, p-value = 0.000,  OR = 7.5, CI = 2,754-20,422. . In asphyxia, it was found 41.7% vs 31.4%, p-value = 0.46. At LBW, it was found 72.7% vs 17.1%, p-value = 0,000, OR = 12.9, CI = 4,285-38,771. In IUGR, it was found that 15.9% vs 2.9%, p-value = 0.000. In stillbirth, it was found 18.2% vs 0% and p-value = 0.008. Conclusion: the onset of severe Preeclampsia is related with perinatal complications. Complications associated with the onset severe Preeclampsia are preterm, LBW, stillbirth. Meanwhile, complications that are not related with the onset severe Preeclampsia are asphyxia and IUGR  

scholarly journals The relationship of the age of onset of obesity to the success of its treatment in the adult

1975 ◽  
Vol 34 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Margaret Ashwell
Keyword(s):  
Early Onset ◽  
Age Of Onset ◽  
Maximum Weight ◽  
Men And Women ◽  
Loss Of Weight ◽  
Relationship Of ◽  
The Relationship

1. A survey was done of 2333 men and women who claimed experience of slimming.2. Their loss of weight was determined from their maximum stated weight and their present weight. The loss of weight was calculated as the percentage of the maximum weight and was related to the stated age of onset of obesity.3. The results showed that those people in the survey who had been fat since childhood had lost just as much weight as those people who had become fat as adults.4. These results suggest that the treatment of early-onset obesity may not be an unrealistic objective.

O3-10-01: DIFFERENT EFFECTS OF APOE ε4 ALLELE ON THE RELATIONSHIP BETWEEN TAU AND β-AMYLOID IN EARLY-ONSET AND LATE-ONSET ALZHEIMER DISEASE

2006 ◽  
Vol 14 (7S_Part_19) ◽  
pp. P1039-P1040
Author(s):  
Young Noh ◽  
Tae Sung Lim ◽  
Sang-Yoon Lee ◽  
Kee Hyung Park ◽  
Dong Jin Shin ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Early Onset ◽  
Late Onset ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Β Amyloid ◽  
The Relationship

Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study

2003 ◽  
Vol 33 (3) ◽  
pp. 541-547 ◽  
Author(s):  
D. C. STEFFENS ◽  
M. C. NORTON ◽  
A. D. HART ◽  
I. SKOOG ◽  
C. CORCORAN ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Late Onset ◽  
Allelic Variation ◽  
Genetic Locus ◽  
Significant Interaction Effect ◽  
Ε4 Allele ◽  
Cache County ◽  
Relationship Of ◽  
The Relationship

Background. The role of allelic variation in APOE, the genetic locus for apolipoprotein E, in geriatric depression is poorly understood. There are conflicting reports as to an association between the ε4 allele and depression in late life.Method. Using a community based study of non-demented elders in Cache County, Utah, that included many very old individuals, we examined the relationship between APOE and late-onset (age >60) depression, with particular attention to possible age effects.Results. There was no overall association between APOE and depression. However, there was a significant interaction effect of APOE and age such that the relationship of late-onset depression with respect to presence of the ε4 allele was larger among those 80 and older compared with those below age 80. Consistent with previous studies, women were more likely to experience late-onset depression than men.Conclusions. Because we excluded prevalent cases of dementia, this pattern of relative risk with age may reflect the appearance of depressive symptoms as a prodrome of Alzheimer's disease or vascular dementia. Longitudinal studies should help to confirm or refute this explanation of the data.

scholarly journals Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae

2016 ◽  
Vol 44 (2) ◽  
pp. 541-545 ◽  
Author(s):  
Hagai Abeliovich ◽  
Jörn Dengjel
Keyword(s):  
Mammalian Cells ◽  
Late Onset ◽  
Specific Form ◽  
Mitochondrial Quality Control ◽  
Evolutionarily Conserved ◽  
Autophagic Degradation ◽  
Relationship Of ◽  
To Receive ◽  
The Relationship ◽  
Significant Attention

The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays a role in physiological homoeostasis as well as in the progression of late-onset diseases. Although the mechanism of bulk degradation by macroautophagy is relatively well established, the selective autophagic degradation of mitochondria has only recently begun to receive significant attention. In this mini-review, we introduce mitophagy as a form of mitochondrial quality control and proceed to provide specific examples from yeast and mammalian systems. We then discuss the relationship of mitophagy to mitochondrial stress, and provide a broad mechanistic overview of the process with an emphasis on evolutionarily conserved pathways.

P76 Angiogenic and anti-angiogenic factors determination in early-onset and late-onset preeclampsia

2010 ◽  
Vol 1 ◽  
pp. S62-S63
Author(s):  
Maria Terezinha Peracoli ◽  
Vera Therezinha Borges ◽  
Camila Ferreira Bannwart ◽  
Leonardo Teixeira Medeiros ◽  
Ingrid Cristina Weel ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Angiogenic Factors

scholarly journals An Unusual Occurrence of Multiple Sclerosis in a Small Rural Community

1976 ◽  
Vol 3 (3) ◽  
pp. 163-166 ◽  
Author(s):  
Thomas John Murray
Keyword(s):  
Multiple Sclerosis ◽  
Age Of Onset ◽  
Late Onset ◽  
Epidemiological Studies ◽  
Farming Community ◽  
Unpasteurized Milk ◽  
Close Proximity ◽  
Unusual Occurrence ◽  
Relationship Of ◽  
The Relationship

SUMMARY:Ten patients with multiple sclerosis were found to have lived in close proximity in a Nova Scotia farming community of 150 people. All had drunk unpasteurized milk as children, were teetotallers, ate a high animal fat diet, and were well educated. Of greater interest was the observation that six of the ten cases were related in two family groups.The only time all patients lived in the community at the same time was in 1951 and 1952 during a polio outbreak. The relationship of polio to multiple sclerosis bears further study.The average age of the patients when they had measles was 11.8 years. Evidence suggests a link between risk of multiple sclerosis and both late onset of measles and pubertal age. Late onset of measles may be important in this cluster. Further epidemiological studies are needed to examine the age of onset of measles in M.S. cases.

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