Placental three-dimensional power Doppler indices in mid-pregnancy and late pregnancy complicated by gestational diabetes mellitus

2013 ◽  
Vol 33 (10) ◽  
pp. 952-958 ◽  
Author(s):  
A. Surányi ◽  
Z. Kozinszky ◽  
A. Molnár ◽  
T. Nyári ◽  
T. Bitó ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Power Doppler ◽  
Three Dimensional ◽  
Late Pregnancy ◽  
Doppler Indices

Three-dimensional ultrasonographic placental volume in gestational diabetes mellitus

2015 ◽  
Vol 29 (4) ◽  
pp. 610-614 ◽  
Author(s):  
Halil Gursoy Pala ◽  
Burcu Artunc-Ulkumen ◽  
Faik Mumtaz Koyuncu ◽  
Yesim Bulbul-Baytur
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Three Dimensional ◽  
Placental Volume

Preliminary evaluation of foetal liver volume by three-dimensional ultrasound in women with gestational diabetes mellitus

2018 ◽  
Vol 38 (7) ◽  
pp. 922-926
Author(s):  
Gülşah İlhan ◽  
Hüseyin Gültekin ◽  
Ayça Kubat ◽  
Ayse Filiz Gokmen Karasu ◽  
Emre Sinan Güngör ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Liver Volume ◽  
Three Dimensional ◽  
Preliminary Evaluation ◽  
Foetal Liver

scholarly journals Gestational diabetes mellitus is as innocent as you think?

2018 ◽  
Vol 7 (9) ◽  
pp. 3526
Author(s):  
Gulsum Uysal ◽  
Mehmet Serdar Kutuk
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Systemic Disease ◽  
Insulin Dosage ◽  
Diabetic Patients ◽  
Pregestational Diabetes ◽  
Significant Difference ◽  
Doppler Indices

Background: We aimed to compare fetal outcomes, fetal hypoxia, acidemia and maternal chracteristics including hemoglobin A1c, doppler indices between gestational diabetes mellitus (GDM) and pregestational diabetes mellitus (DM) among pregnant women treated with insulin.Methods: Data of pregnant patients with diagnosis of pregestational diabetes (type 1 and 2) and GDM who were treated with insulin (GDM A2 in White classification) was retrospectively collected and compared. Patients with active chronic systemic disease, multiple pregnancies, lost to follow up and detected fetal malformations were exluded. Maternal characteristics, umbilical doppler indices and amnion fluid index, gestational age at delivery, delivery characteristics (including vaginal delivery, or cesarean section) and newborn characteristics such as birth weight, Apgar score and umblical cord pH were all recorded.Results: A total of 130 patients (67 patients with GDM and 63 pregestational DM) were recruited to the study. There were no significant difference regarding type of delivery, fetal birth weight, umbilical cord Hb and gestational birth age. No other significant difference in frequency of low Apgar scores and fetal acidosis or metabolic acidosis were reported. HbA1c and blood glucose levels and insulin dosage were significantly statistically higher in pregestational group.Conclusions: The frequency of fetal distress parameters and poor fetal outcome were similar between groups although pregestaional diabetic patients had higher HbA1c rates. Therefore, patients with GDM (A2) should be followed up as closely as pregestational (overt) diabetic patients.

scholarly journals miR-410 enhanced hESC-derived pancreatic endoderm transplant to alleviate gestational diabetes mellitus

2015 ◽  
Vol 55 (3) ◽  
pp. 219-229 ◽  
Author(s):  
Yang Mi ◽  
Na Guo ◽  
Tongqiang He ◽  
Jing Ji ◽  
Zhibin Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Embryonic Stem ◽  
Late Pregnancy ◽  
Β Cells ◽  
Pregnant Females ◽  
Pancreatic Progenitors ◽  
First Time

Gestational diabetes mellitus (GDM) is a condition commonly encountered during mid to late pregnancy with pathologic manifestations including hyperglycemia, hyperinsulinemia, insulin resistance, and fetal mal-development. The deficit and dysfunction of insulin secreting β-cells are signature symptoms for GDM. Pancreatic progenitors derived from human embryonic stem cells (hESCs) were shown to be able to effectively treat diabetes in mice. In this study, we first identified that microRNA-410 (miR-410) directly targets lactate dehydrogenase A (LDHA), a gene selectively repressed in normal insulin secreting β-cells. hESCs that can be induced to express miR-410 hence keeping LDHA levels in check were then differentiatedin vitrointo pancreatic endoderm, followed by transplantation intodb/+mouse model of GDM. The transplant greatly improved glucose metabolism and reproductive outcome of the pregnant females suffering from GDM. Our findings describe for the first time the method of combining miRNA with hESCs, providing proof of concept by employing genetically modified stem cell therapy for treating GDM.

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