Distinctive pattern of first trimester maternal serum biochemical markers in trisomy 22 pregnancies

2008 ◽  
Vol 28 (12) ◽  
pp. 1174-1176 ◽  
Author(s):  
S. Sifakis ◽  
M. Karkaletsi ◽  
S. Christopoulou ◽  
J. Donoghue ◽  
P. Kaminopetros ◽  
...  
Keyword(s):  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Distinctive Pattern ◽  
Serum Biochemical

scholarly journals Maternal serum biochemical markers combined with ultrasound diagnosis at the end of the first trimester

2021 ◽  
Vol 26 (4) ◽  
pp. 2879-2884
Author(s):  
MARIUS CRISTIAN MARINAȘ ◽  
LUCIAN GEORGE ZORILĂ ◽  
CIPRIAN LAURENȚIU PĂTRU ◽  
TIBERIU ȘTEFĂNIȚĂ ȚENEA COJAN ◽  
VLAD DUMITRU BALEANU ◽  
...  
Keyword(s):  
Biochemical Markers ◽  
Protein A ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Serum ◽  
Early Screening ◽  
Crown Rump Length ◽  
Chamber View ◽  
Great Vessel Anomalies ◽  
Serum Biochemical

Objectives. Evaluating the benefits of an early screening of combined maternal markers and ultrasound of the fetuses. Methods. Prospective study (1 January and 31 December 2018) enrolled 187 patients, evaluated at the end of the first trimester of pregnancy (nuchal scan). Biochemical markers: detection of free β human chorionic gonadotropin and serum pregnancy associated plasma protein A. The first trimester ultrasound examination included the assessment of the nuchal translucency, fetal crown rump length and fetal heart. Results. 9 cases with abnormal biomarkers, increased nuchal translucency and cardiac anomalies, including abnormal 4-chamber view (6 cases) and great vessel anomalies (3 cases). 1 case considered initially negative in the first trimester was diagnosed by morphological scan with tetralogy of Fallot in the second trimester. Conclusions. A first trimester combined ultrasound protocol and maternal serum biochemical markers is important in the early prenatal care screening.

scholarly journals Understanding Biochemical Markers for Antenatal Screening

2010 ◽  
Vol 4 (4) ◽  
pp. 333-335
Keyword(s):  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Molecular Techniques ◽  
Screening Tests ◽  
Maternal Circulation ◽  
Beta Hcg ◽  
Increased Risk ◽  
Cell Free Fetal Dna ◽  
Serum Biochemical

ABSTRACT Screening tests to identify fetuses at risk for aneuploidies should be offered to all pregnant women. It should be remembered that screening tests can not diagnose a birth defect; they can only indicate an increased risk. An abnormal screening test result simply mean that additional testing is recommended. Maternal serum biochemical markers in first trimester are free beta-hCG and PAPP-A. In second trimester the markers are AFP, UE3, hCG (Triple test) and inhibin added to these three markers forming the quadruple test. Level of cell free fetal DNA and fetal cells in maternal circulation are some of the molecular techniques for prenatal diagnosis of aneuploidies.

scholarly journals The Effect of Down Syndrome Biochemical Markers on Predicting Severity of Preeclampsia

2020 ◽  
Author(s):  
AYSE OZBAN
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tests ◽  
Second Trimester ◽  
Study Results ◽  
Second Trimester Screening ◽  
Trimester Screening

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

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