The impact of screening for open neural tube defects in England and Wales

1987 ◽  
Vol 7 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Howard Cuckle ◽  
Nicholas Wald
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
England And Wales ◽  
The Impact

Alpha-fetoprotein detection of neural tube defects and the impact of standard ultrasound

2006 ◽  
Vol 195 (6) ◽  
pp. 1623-1628 ◽  
Author(s):  
Jodi S. Dashe ◽  
Diane M. Twickler ◽  
Rigoberto Santos-Ramos ◽  
Donald D. McIntire ◽  
Ronald M. Ramus
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Alpha Fetoprotein ◽  
The Impact

Prevalence of Neural Tube Defects and the Impact of Prenatal Diagnosis in Three Districts of Beijing, China

2017 ◽  
Vol 31 (4) ◽  
pp. 293-300 ◽  
Author(s):  
Lei Jin ◽  
Lei Jin ◽  
Jingru Yu ◽  
Yanjun Xu ◽  
Hui Liu ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
The Impact ◽  
Beijing China

scholarly journals Impact of folic acid fortification of flour on neural tube defects: a systematic review

2012 ◽  
Vol 16 (5) ◽  
pp. 901-911 ◽  
Author(s):  
Cecilia Castillo-Lancellotti ◽  
Josep A Tur ◽  
Ricardo Uauy
Keyword(s):  
Systematic Review ◽  
Folic Acid ◽  
Costa Rica ◽  
Latin American ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Fortification ◽  
Potential Association ◽  
The Usa ◽  
The Impact

AbstractObjectiveTo review the impact of folic acid fortification of flour on the prevalence of neural tube defects (NTD).DesignSystematic review of the literature on MEDLINE via PubMed, Scopus, OvidSP and LILACS (Latin American and Caribbean Health Sciences Literature) reporting the impact of folic acid fortification of flour on the prevalence of NTD in 2000–2011. Focusing on Santiago of Chile's birth defects registry (1999–2009) and the monitoring of flour fortification, we analysed the prevalence (NTD cases/10 000 births) pre and post flour fortification and the percentile distribution of folic acid content in flour (2005–2009). We explored the potential association between median folic acid in flour (mg/kg) and the prevalence of NTD.SettingChile, Argentina, Brazil, Canada, Costa Rica, Iran, Jordan, South Africa and the USA.SubjectsLive births and stillbirths.ResultsTwenty-seven studies that met inclusion criteria were evaluated. Costa Rica showed a significant reduction in NTD (∼60 %). Prevalence in Chile decreased from 18·6 to 7·3/10 000 births from 1999 to 2007 and showed a slight increase to 8·5 in 2008–2009, possibly due to changes in fortification limits. When we related the prevalence of NTD with levels of flour fortification, the lowest prevalence was observed at a folic acid level of 1·5 mg/kg.ConclusionsFortification of flour with folic acid has had a major impact on NTD in all countries where this has been reported. Chile showed a 55 % reduction in NTD prevalence between 1999 and 2009. There is a need to constantly monitor the levels of flour fortification to maximize benefits and prevent the potential risk of folic acid excess, moreover to be vigilant for any new adverse effects associated with excess.

Impact of an Online Educational Program on Pharmacy Students’ Knowledge of Folic Acid and Neural Tube Defects

2014 ◽  
Vol 27 (5) ◽  
pp. 513-517 ◽  
Author(s):  
Margarita Bykhovsky ◽  
Mary Frances K. Meier ◽  
Natalie A. DiPietro Mager
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Educational Program ◽  
Pharmacy Students ◽  
Educational Video ◽  
Online Videos ◽  
Baseline Knowledge ◽  
Health Need ◽  
The Impact

Purpose: Pharmacy students must receive adequate training regarding folic acid for the prevention of neural tube defects (NTDs). Pharmacy students’ knowledge should be evaluated and effective methods utilized to improve it, if needed. The objective of this study was to assess baseline knowledge among third-year students in a 0-6 Doctor of Pharmacy program and to evaluate the impact of an online educational video. Methods: Baseline knowledge was assessed by a pretest adapted with permission from the March of Dimes (MOD). Students watched a 30-minute MOD video and completed a posttest. Nine months later, students completed a longitudinal posttest. Analysis of variance was used to assess differences in the percentage of correct responses to each question. Results: A total of 133 (90.5%) students completed the educational program and 105 (78.9%) completed the longitudinal test. Statistically significant improvements in knowledge from baseline were seen for 9 of 10 questions on the posttest and for 6 of 10 questions on the longitudinal test. Conclusion: Online videos are tools to teach pharmacy students key information regarding folic acid and NTD; however, material should be reinforced in experiential education as well. Counseling women of childbearing potential about folic acid fulfills an important public health need.

scholarly journals Predicting the Impact of Mandatory Folic Acid Fortification on Neural Tube Defects in New Zealand

Proceedings ◽  
2019 ◽  
Vol 37 (1) ◽  
pp. 17
Author(s):  
Michelle Gibbs ◽  
Rebecca Doonan ◽  
Peter van der Logt ◽  
Julie Boorman
Keyword(s):  
Folic Acid ◽  
New Zealand ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Compelling Evidence ◽  
Folic Acid Fortification ◽  
The Impact

Background: There is compelling evidence that mandatory fortification of food with folic acid reduces the prevalence of neural tube defects (NTDs).[...]

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