Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid)

2017 ◽  
Vol 39 ◽  
pp. E416-E425 ◽  
Author(s):  
Wenyuan Dong ◽  
Qinhuan Zeng ◽  
Xueqiong Yin ◽  
Haifang Liu ◽  
Ju Lv ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Compatibility ◽  
Poly Lactic Acid

Biodegradable Microfluidic Device: Hydrolysis, Decomposition and Surface Modification

2010 ◽  
Vol 447-448 ◽  
pp. 755-759 ◽  
Author(s):  
Jia En Low ◽  
Wei Xiang Koh ◽  
Joon Kit Lai ◽  
Yan Jie Lee ◽  
Xu Li ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Microfluidic Device ◽  
Ph Value ◽  
Blood Compatibility ◽  
Blood Clot ◽  
Hydrophobic Surface ◽  
Poly Lactic Acid ◽  
Water Contact ◽  
Chemical Grafting ◽  
Poly Ethylene

Poly(lactic acid) (PLA) is a biodegradable and biocompatible aliphatic polyester whose lactic acid monomers are derived from renewable resources such as corn and sugar beet. As a thermal plastic it can be processed through compounding and injection. As such, we have developed a microfludic device using PLA aimed at blood dialysis application. To quantify the degradation of PLA, its hydrolysis at different pH value was studied. To study the bioresorbable property of these fabricated devices, its decomposition was tested by morphology observation and weight change measurements after embedding in soil under simulated environmental conditions. Upon contact with a hydrophobic surface, platelets and prothrombin are always activated to attach to the surface, resulting in blood clot. This would block the blood flow through the dialysis channels in the microfluidic device. To improve the hydrophilicity, hence the blood compatibility, chemical grafting of a hydrophilic polymer, poly(ethylene oxide) methacrylate (PEGmA), onto the surface of PLA microfluidic device was carried out and the changes in hydrophilicity was monitored through measuring the water contact angle. Our results indicate that chemical grafting of PEGmA significantly improves the hydrophilicity of the device surface.

Blood compatibility evaluations of poly(ethylene glycol)–poly(lactic acid) copolymers

2016 ◽  
Vol 30 (10) ◽  
pp. 1485-1493 ◽  
Author(s):  
Chenghua Li ◽  
Chengyan Ma ◽  
Yi Zhang ◽  
Zonghua Liu ◽  
Wei Xue
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Blood Compatibility ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Fibrillation of chain branched poly (lactic acid) with improved blood compatibility and bionic structure

2015 ◽  
Vol 279 ◽  
pp. 767-776 ◽  
Author(s):  
Zhengqiu Li ◽  
Xiaowen Zhao ◽  
Lin Ye ◽  
Phil Coates ◽  
Fin Caton-Rose ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Compatibility ◽  
Poly Lactic Acid ◽  
Bionic Structure

scholarly journals High orientation of long chain branched poly (lactic acid) with enhanced blood compatibility and bionic structure

2016 ◽  
Vol 104 (5) ◽  
pp. 1082-1089 ◽  
Author(s):  
Zhengqiu Li ◽  
Lin Ye ◽  
Xiaowen Zhao ◽  
Phil Coates ◽  
Fin Caton-Rose ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Compatibility ◽  
Poly Lactic Acid ◽  
Bionic Structure ◽  
High Orientation ◽  
Long Chain

Electrical Properties of Heat-Treated Poly-Lactic Acid

2011 ◽  
Vol 131 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Toru Oi ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita
Keyword(s):  
Lactic Acid ◽  
Electrical Properties ◽  
Poly Lactic Acid ◽  
Heat Treated

Dielectric Breakdown Properties of Poly-Lactic Acid with Spherulites Growth

2014 ◽  
Vol 134 (4) ◽  
pp. 237-242
Author(s):  
Naru Matsugasaki ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita
Keyword(s):  
Lactic Acid ◽  
Dielectric Breakdown ◽  
Poly Lactic Acid
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