scholarly journals High orientation of long chain branched poly (lactic acid) with enhanced blood compatibility and bionic structure

2016 ◽  
Vol 104 (5) ◽  
pp. 1082-1089 ◽  
Author(s):  
Zhengqiu Li ◽  
Lin Ye ◽  
Xiaowen Zhao ◽  
Phil Coates ◽  
Fin Caton-Rose ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Compatibility ◽  
Poly Lactic Acid ◽  
Bionic Structure ◽  
High Orientation ◽  
Long Chain

scholarly journals Fibrillation of chain branched poly (lactic acid) with improved blood compatibility and bionic structure

2015 ◽  
Vol 279 ◽  
pp. 767-776 ◽  
Author(s):  
Zhengqiu Li ◽  
Xiaowen Zhao ◽  
Lin Ye ◽  
Phil Coates ◽  
Fin Caton-Rose ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Compatibility ◽  
Poly Lactic Acid ◽  
Bionic Structure

Biodegradable Microfluidic Device: Hydrolysis, Decomposition and Surface Modification

2010 ◽  
Vol 447-448 ◽  
pp. 755-759 ◽  
Author(s):  
Jia En Low ◽  
Wei Xiang Koh ◽  
Joon Kit Lai ◽  
Yan Jie Lee ◽  
Xu Li ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Microfluidic Device ◽  
Ph Value ◽  
Blood Compatibility ◽  
Blood Clot ◽  
Hydrophobic Surface ◽  
Poly Lactic Acid ◽  
Water Contact ◽  
Chemical Grafting ◽  
Poly Ethylene

Poly(lactic acid) (PLA) is a biodegradable and biocompatible aliphatic polyester whose lactic acid monomers are derived from renewable resources such as corn and sugar beet. As a thermal plastic it can be processed through compounding and injection. As such, we have developed a microfludic device using PLA aimed at blood dialysis application. To quantify the degradation of PLA, its hydrolysis at different pH value was studied. To study the bioresorbable property of these fabricated devices, its decomposition was tested by morphology observation and weight change measurements after embedding in soil under simulated environmental conditions. Upon contact with a hydrophobic surface, platelets and prothrombin are always activated to attach to the surface, resulting in blood clot. This would block the blood flow through the dialysis channels in the microfluidic device. To improve the hydrophilicity, hence the blood compatibility, chemical grafting of a hydrophilic polymer, poly(ethylene oxide) methacrylate (PEGmA), onto the surface of PLA microfluidic device was carried out and the changes in hydrophilicity was monitored through measuring the water contact angle. Our results indicate that chemical grafting of PEGmA significantly improves the hydrophilicity of the device surface.

scholarly journals Star Shaped Long Chain Branched Poly (lactic acid) Prepared by Melt Transesterification with Trimethylolpropane Triacrylate and Nano-ZnO

Polymers ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 796 ◽  
Author(s):  
Le Yang ◽  
Zaijun Yang ◽  
Feng Zhang ◽  
Lijin Xie ◽  
Zhu Luo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
High Efficiency ◽  
Synergistic Effects ◽  
Transesterification Reaction ◽  
Poly Lactic Acid ◽  
Cell Diameter ◽  
Nano Zno ◽  
Melt Strength ◽  
Trimethylolpropane Triacrylate ◽  
Long Chain

Long chain branched poly (lactic acid) (LCBPLA) was prepared via transesterification between high molecular weight poly (lactic acid) (PLA) and low molar mass monomer trimethylolpropane triacrylate (TMPTA) during melt blending in the presence of zinc oxide nanoparticles (nano-ZnO) as a transesterification accelerant in a torque rheometer. Compared with the traditional processing methods, this novel way is high-efficiency, environmentally friendly, and gel-free. The results revealed that chain restructuring reactions occurred and TMPTA was grafted onto the PLA backbone. The topological structures of LCBPLA were verified and investigated in detail. It was found that the concentration of the accelerants and the sampling occasion had very important roles in the occurrence of branching structures. When the nano-ZnO dosage was 0.4 phr and PLA was sampled at the time corresponding to the reaction peak in the torque curve, PLA exhibited a star-shaped topological structure with a high branching degree which could obviously affect the melt strength, extrusion foaming performances, and crystallization behaviors. Compared with pristine PLA, LCBPLA showed a higher melt strength, smaller cell diameter, and slower crystallization speed owing to the synergistic effects of nano-ZnO and the long chain branches introduced by the transesterification reaction in the system. However, severe degradation of the LCBPLAs would take place under a mixing time that was too long and lots of short linear chains generated due to the excessive transesterification reaction, with a sharp decline in melt strength.

Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid)

2017 ◽  
Vol 39 ◽  
pp. E416-E425 ◽  
Author(s):  
Wenyuan Dong ◽  
Qinhuan Zeng ◽  
Xueqiong Yin ◽  
Haifang Liu ◽  
Ju Lv ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Compatibility ◽  
Poly Lactic Acid

Blood compatibility evaluations of poly(ethylene glycol)–poly(lactic acid) copolymers

2016 ◽  
Vol 30 (10) ◽  
pp. 1485-1493 ◽  
Author(s):  
Chenghua Li ◽  
Chengyan Ma ◽  
Yi Zhang ◽  
Zonghua Liu ◽  
Wei Xue
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Blood Compatibility ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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