Invasive pneumococcal disease in children with sickle cell disease in the pneumococcal conjugate vaccine era

2017 ◽  
Vol 65 (1) ◽  
pp. e26713 ◽  
Author(s):  
Olufunke O. Martin ◽  
Kristin L. Moquist ◽  
Jane M. Hennessy ◽  
Stephen C. Nelson
Keyword(s):  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Invasive Pneumococcal Disease ◽  
Sickle Cell ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Disease ◽  
Cell Disease

scholarly journals Nasopharyngeal Carriage of Methicillin-Resistant Staphylococcus aureus (MRSA) among Sickle Cell Disease (SCD) Children in the Pneumococcal Conjugate Vaccine Era

2021 ◽  
Vol 13 (1) ◽  
pp. 191-204
Author(s):  
Nicholas T. K. D. Dayie ◽  
Deborah N. K. Sekoh ◽  
Fleischer C. N. Kotey ◽  
Beverly Egyir ◽  
Patience B. Tetteh-Quarcoo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Sickle Cell ◽  
Pneumococcal Conjugate Vaccine ◽  
Diffusion Method ◽  
Nasopharyngeal Carriage ◽  
Cell Disease ◽  
Coagulase Negative Staphylococci ◽  
Methicillin Resistant

The aim of this cross-sectional study was to investigate Staphylococcus aureus nasopharyngeal carriage epidemiology in relation to other nasopharyngeal bacterial colonizers among sickle cell disease (SCD) children about five years into pneumococcal conjugate vaccine 13 (PCV-13) introduction in Ghana. The study involved bacteriological culture of nasopharyngeal swabs obtained from 202 SCD children recruited from the Princess Marie Louise Children’s Hospital. S. aureus isolates were identified using standard methods and subjected to antimicrobial susceptibility testing using the Kirby-Bauer disc diffusion method. Cefoxitin-resistant S. aureus isolates were screened for carriage of the mecA, pvl, and tsst-1 genes using multiplex polymerase chain reaction. The carriage prevalence of S. aureus was 57.9% (n = 117), and that of methicillin-resistant S. aureus (MRSA) was 3.5% (n = 7). Carriage of the mecA, pvl, and tsst-1 genes were respectively demonstrated in 20.0% (n = 7), 85.7% (n = 30), and 11.4% (n = 4) of the cefoxitin-resistant S. aureus isolates. PCV-13 vaccination (OR = 0.356, p = 0.004) and colonization with coagulase-negative staphylococci (CoNS) (OR = 0.044, p < 0.0001) each protected against S. aureus carriage. However, none of these and other features of the participants emerged as a determinant of MRSA carriage. The following antimicrobial resistance rates were observed in MRSA compared to methicillin-sensitive S. aureus: clindamycin (28.6% vs. 4.3%), erythromycin (42.9% vs. 19.1%), tetracycline (100% vs. 42.6%), teicoplanin (14.3% vs. 2.6%), penicillin (100% vs. 99.1%), amoxiclav (28.6% vs. 3.5%), linezolid (14.3% vs. 0.0%), ciprofloxacin (42.9% vs. 13.9%), and gentamicin (42.9% vs. 13.0%). The proportion of S. aureus isolates that were multidrug resistant was 37.7% (n = 46). It is concluded that S. aureus was the predominant colonizer of the nasopharynx of the SCD children, warranting the continuous monitoring of this risk group for invasive S. aureus infections.

Invasive Pneumococcal Disease in Patients With Sickle Cell Disease

2017 ◽  
Vol 39 (5) ◽  
pp. 341-344 ◽  
Author(s):  
Pournima Navalkele ◽  
Bülent Özgönenel ◽  
Eric McGrath ◽  
Paul Lephart ◽  
Sharada Sarnaik
Keyword(s):  
Sickle Cell Disease ◽  
Invasive Pneumococcal Disease ◽  
Sickle Cell ◽  
Pneumococcal Disease ◽  
Cell Disease

scholarly journals Invasive Pneumococcal Disease Among Children With and Without Sickle Cell Disease in the United States, 1998 to 2009

2013 ◽  
Vol 32 (12) ◽  
pp. 1308-1312 ◽  
Author(s):  
Amanda B. Payne ◽  
Ruth Link-Gelles ◽  
Ijeoma Azonobi ◽  
W. Craig Hooper ◽  
Bernard W. Beall ◽  
...  
Keyword(s):  
United States ◽  
Sickle Cell Disease ◽  
Invasive Pneumococcal Disease ◽  
Sickle Cell ◽  
Pneumococcal Disease ◽  
The United States ◽  
Cell Disease
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