scholarly journals Nasopharyngeal carriage rate of Streptococcus pneumoniae in children with sickle cell disease before and after the introduction of heptavalent pneumococcal conjugate vaccine

2008 ◽  
Vol 1 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Ellie Alexander ◽  
Paul Telfer ◽  
Harunor Rashid ◽  
Kamal A. Ali ◽  
Robert Booy
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Sickle Cell ◽  
Pneumococcal Conjugate Vaccine ◽  
Nasopharyngeal Carriage ◽  
Cell Disease ◽  
Carriage Rate ◽  
Before And After ◽  
Heptavalent Pneumococcal Conjugate Vaccine

scholarly journals Nasopharyngeal Carriage of Methicillin-Resistant Staphylococcus aureus (MRSA) among Sickle Cell Disease (SCD) Children in the Pneumococcal Conjugate Vaccine Era

2021 ◽  
Vol 13 (1) ◽  
pp. 191-204
Author(s):  
Nicholas T. K. D. Dayie ◽  
Deborah N. K. Sekoh ◽  
Fleischer C. N. Kotey ◽  
Beverly Egyir ◽  
Patience B. Tetteh-Quarcoo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Sickle Cell ◽  
Pneumococcal Conjugate Vaccine ◽  
Diffusion Method ◽  
Nasopharyngeal Carriage ◽  
Cell Disease ◽  
Coagulase Negative Staphylococci ◽  
Methicillin Resistant

The aim of this cross-sectional study was to investigate Staphylococcus aureus nasopharyngeal carriage epidemiology in relation to other nasopharyngeal bacterial colonizers among sickle cell disease (SCD) children about five years into pneumococcal conjugate vaccine 13 (PCV-13) introduction in Ghana. The study involved bacteriological culture of nasopharyngeal swabs obtained from 202 SCD children recruited from the Princess Marie Louise Children’s Hospital. S. aureus isolates were identified using standard methods and subjected to antimicrobial susceptibility testing using the Kirby-Bauer disc diffusion method. Cefoxitin-resistant S. aureus isolates were screened for carriage of the mecA, pvl, and tsst-1 genes using multiplex polymerase chain reaction. The carriage prevalence of S. aureus was 57.9% (n = 117), and that of methicillin-resistant S. aureus (MRSA) was 3.5% (n = 7). Carriage of the mecA, pvl, and tsst-1 genes were respectively demonstrated in 20.0% (n = 7), 85.7% (n = 30), and 11.4% (n = 4) of the cefoxitin-resistant S. aureus isolates. PCV-13 vaccination (OR = 0.356, p = 0.004) and colonization with coagulase-negative staphylococci (CoNS) (OR = 0.044, p < 0.0001) each protected against S. aureus carriage. However, none of these and other features of the participants emerged as a determinant of MRSA carriage. The following antimicrobial resistance rates were observed in MRSA compared to methicillin-sensitive S. aureus: clindamycin (28.6% vs. 4.3%), erythromycin (42.9% vs. 19.1%), tetracycline (100% vs. 42.6%), teicoplanin (14.3% vs. 2.6%), penicillin (100% vs. 99.1%), amoxiclav (28.6% vs. 3.5%), linezolid (14.3% vs. 0.0%), ciprofloxacin (42.9% vs. 13.9%), and gentamicin (42.9% vs. 13.0%). The proportion of S. aureus isolates that were multidrug resistant was 37.7% (n = 46). It is concluded that S. aureus was the predominant colonizer of the nasopharynx of the SCD children, warranting the continuous monitoring of this risk group for invasive S. aureus infections.

scholarly journals Nasopharyngeal carriage rate of Streptococcus pneumoniae in Ugandan children with Sickle Cell Disease

2012 ◽  
Vol 5 (1) ◽  
pp. 28 ◽  
Author(s):  
David P Kateete ◽  
Henry Kajumbula ◽  
Deogratias H Kaddu-Mulindwa ◽  
Augustine K Ssevviri
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Nasopharyngeal Carriage ◽  
Cell Disease ◽  
Carriage Rate

scholarly journals Penicillin Resistance in Nasopharyngeal <i>Streptococcus pneumoniae</i> among Children with Sickle Cell Disease Immunized with 7-Valent Pneumococcal Conjugate Vaccine

2013 ◽  
Vol 03 (02) ◽  
pp. 25-31 ◽  
Author(s):  
Patricia Belintani Blum Fonseca ◽  
Calil Kairalla Farhat ◽  
Regina Célia de Menezes Succi ◽  
Antônia Maria de Oliveira Machado ◽  
Josefina Aparecida Pellegrini Braga
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Sickle Cell ◽  
Pneumococcal Conjugate Vaccine ◽  
Penicillin Resistance ◽  
Cell Disease

scholarly journals Serum Opsonic Activity for Streptococcus pneumoniae Types 6B and 14 in Infants with Sickle Cell Disease after Immunization with Pneumococcal Protein Conjugate Vaccine

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 11A-11A
Author(s):  
Anna H Nowak-Wegrzyn ◽  
Jerry A Winkelstein ◽  
Beth M Stover ◽  
Andrea J Swift ◽  
Howard M Lederman
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sickle Cell Disease ◽  
Conjugate Vaccine ◽  
Sickle Cell ◽  
Cell Disease ◽  
Opsonic Activity ◽  
Protein Conjugate

Nasopharyngeal Carriage of Penicillin-resistant Streptococcus pneumoniae in Children With Sickle Cell Disease

PEDIATRICS ◽  
1997 ◽  
Vol 99 (4) ◽  
pp. e7-e7 ◽  
Author(s):  
N. C. Daw ◽  
J. A. Wilimas ◽  
W. C. Wang ◽  
G. J. Presbury ◽  
R. E. Joyner ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Nasopharyngeal Carriage ◽  
Cell Disease
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