Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species

2018 ◽  
Vol 244 (3) ◽  
pp. 346-357 ◽  
Author(s):  
Yuki Kitano ◽  
Yoshifumi Baba ◽  
Shigeki Nakagawa ◽  
Keisuke Miyake ◽  
Masaaki Iwatsuki ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Oesophageal Cancer ◽  
Reactive Oxygen ◽  
Metabolic Reprogramming ◽  
Cancer Cell Proliferation ◽  
Oxygen Species ◽  
Oesophageal Cancer Cell

scholarly journals (172) Strawberries Inhibit Cancer Cell Proliferation

HortScience ◽  
2006 ◽  
Vol 41 (4) ◽  
pp. 1082B-1082
Author(s):  
Shiow Wang ◽  
Kimberly Lewers ◽  
Linda Bowman ◽  
Min Ding
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Inhibitory Effect ◽  
Cancer Cell Proliferation ◽  
Oxygen Species ◽  
Scavenging Capacity ◽  
Lung Epithelial ◽  
Fragaria Virginiana

Representatives of three species of strawberries (Fragaria virginiana, F. chiloensis and F. ×ananassa) were evaluated for antioxidant capacity, scavenging capacity for reactive oxygen species (ROO·, ·OH, 1O2 and O2 .-), and inhibitory effect on proliferation of A549 human lung epithelial cancer cells. Differences among the strawberry genotypes were observed for all three qualities. High antioxidant and scavenging capacities were found in `CFRA 0982', `JP 95-1-1', NC 95-19-1 and RH 30. Lowest antioxidant and scavenging capacities were found in `Allstar'. There was also a relationship between scavenging capacity and the inhibition of cancer cell proliferation. The correlations (R2) between the scavenging capacities for the reactive oxygen species and the inhibition of cancer cell proliferation were 0.8074, 0.8279, 0.7862 and 0.7761 for ROO·, ·OH, 1O2 and O2.-, respectively. These results suggest that antioxidants, specifically their scavenging capacities, may play an important role in the antiproliferative activity of strawberries. This study also identified strawberry germplasm of value in developing cultivars useful for cancer prevention.

scholarly journals Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels

2014 ◽  
Vol 20 (4) ◽  
pp. 650-661 ◽  
Author(s):  
Nishi Srivastava ◽  
Rahul K. Kollipara ◽  
Dinesh K. Singh ◽  
Jessica Sudderth ◽  
Zeping Hu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Cancer Cell Proliferation ◽  
Oxygen Species ◽  
Metabolic Switch

Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation

2021 ◽  
Author(s):  
Qian Wu ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Organelle Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of...

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