Synthetic β-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction

Head & Neck ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 1055-1064 ◽  
Author(s):  
Yen-Yun Wang ◽  
Yuk-Kwan Chen ◽  
Ya-Ling Hsu ◽  
Wen-Chin Chiu ◽  
Chun-Hao Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Oral Cancer ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Cancer Cell Proliferation ◽  
Oxygen Species ◽  
Oral Cancer Cell

scholarly journals (172) Strawberries Inhibit Cancer Cell Proliferation

HortScience ◽  
2006 ◽  
Vol 41 (4) ◽  
pp. 1082B-1082
Author(s):  
Shiow Wang ◽  
Kimberly Lewers ◽  
Linda Bowman ◽  
Min Ding
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Inhibitory Effect ◽  
Cancer Cell Proliferation ◽  
Oxygen Species ◽  
Scavenging Capacity ◽  
Lung Epithelial ◽  
Fragaria Virginiana

Representatives of three species of strawberries (Fragaria virginiana, F. chiloensis and F. ×ananassa) were evaluated for antioxidant capacity, scavenging capacity for reactive oxygen species (ROO·, ·OH, 1O2 and O2 .-), and inhibitory effect on proliferation of A549 human lung epithelial cancer cells. Differences among the strawberry genotypes were observed for all three qualities. High antioxidant and scavenging capacities were found in `CFRA 0982', `JP 95-1-1', NC 95-19-1 and RH 30. Lowest antioxidant and scavenging capacities were found in `Allstar'. There was also a relationship between scavenging capacity and the inhibition of cancer cell proliferation. The correlations (R2) between the scavenging capacities for the reactive oxygen species and the inhibition of cancer cell proliferation were 0.8074, 0.8279, 0.7862 and 0.7761 for ROO·, ·OH, 1O2 and O2.-, respectively. These results suggest that antioxidants, specifically their scavenging capacities, may play an important role in the antiproliferative activity of strawberries. This study also identified strawberry germplasm of value in developing cultivars useful for cancer prevention.

scholarly journals Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels

2014 ◽  
Vol 20 (4) ◽  
pp. 650-661 ◽  
Author(s):  
Nishi Srivastava ◽  
Rahul K. Kollipara ◽  
Dinesh K. Singh ◽  
Jessica Sudderth ◽  
Zeping Hu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Cancer Cell Proliferation ◽  
Oxygen Species ◽  
Metabolic Switch

scholarly journals STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 457 ◽  
Author(s):  
Janina Frisch ◽  
Adrian Angenendt ◽  
Markus Hoth ◽  
Leticia Prates Roma ◽  
Annette Lis
Keyword(s):  
Reactive Oxygen Species ◽  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Blood Vessels ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Soluble Factors ◽  
Orai Channels

The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the extracellular matrix, soluble factors, and blood vessels. Interactions between the cells, matrix, soluble factors, and blood vessels generate this complex heterogeneous microenvironment. The TME may be metabolically beneficial or unbeneficial for tumor growth, it may favor or not favor a productive immune response against tumor cells, or it may even favor conditions suited to hijacking the immune system for benefitting tumor growth. Soluble factors relevant for TME include oxygen, reactive oxygen species (ROS), ATP, Ca2+, H+, growth factors, or cytokines. Ca2+ plays a prominent role in the TME because its concentration is directly linked to cancer cell proliferation, apoptosis, or migration but also to immune cell function. Stromal-interaction molecules (STIM)-activated Orai channels are major Ca2+ entry channels in cancer cells and immune cells, they are upregulated in many tumors, and they are strongly regulated by ROS. Thus, STIM and Orai are interesting candidates to regulate cancer cell fate in the TME. In this review, we summarize the current knowledge about the function of ROS and STIM/Orai in cancer cells; discuss their interdependencies; and propose new hypotheses how TME, ROS, and Orai channels influence each other.

scholarly journals Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells

2016 ◽  
Vol 21 (1) ◽  
pp. 419-427 ◽  
Author(s):  
Cheng-Yu Yang ◽  
Chih-Kung Lin ◽  
Gu-Jiun Lin ◽  
Cheng-Chih Hsieh ◽  
Shing-Hwa Huang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
U937 Cells ◽  
Oral Cancer Cell
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