scholarly journals A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency

2012 ◽  
Vol 228 (4) ◽  
pp. 586-595 ◽  
Author(s):  
Sun Tian ◽  
Paul Roepman ◽  
Vlad Popovici ◽  
Magali Michaut ◽  
Ian Majewski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Mutation Frequency ◽  
Genomic Signature ◽  
High Mutation Frequency ◽  
Colorectal Cancer Patients ◽  
Instability Phenotype

scholarly journals Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients

2013 ◽  
Vol 21 (12) ◽  
pp. 1383-1388 ◽  
Author(s):  
Giovanni Corso ◽  
Valeria Pascale ◽  
Giuseppe Flauti ◽  
Francesco Ferrara ◽  
Daniele Marrelli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Oncogenic Mutations ◽  
Colorectal Cancer Patients ◽  
Instability Phenotype

scholarly journals Advantage of HSP110 (T17) marker inclusion for microsatellite instability (MSI) detection in colorectal cancer patients

Oncotarget ◽  
2018 ◽  
Vol 9 (47) ◽  
pp. 28691-28701 ◽  
Author(s):  
Gustavo Noriz Berardinelli ◽  
Cristovam Scapulatempo-Neto ◽  
Ronílson Durães ◽  
Marco Antônio de Oliveira ◽  
Denise Guimarães ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Impact of Preoperative Microsatellite Instability Testing on Surgical Management in Young-Onset Colorectal Cancer Patients: Results From a Reflex Testing Protocol

2011 ◽  
Vol 140 (5) ◽  
pp. S-1031-S-1032
Author(s):  
Jennifer Holder-Murray ◽  
Rajesh Pendlimari ◽  
Lisa Boardman ◽  
Thomas C. Smyrk ◽  
David W. Larson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Surgical Management ◽  
Young Onset ◽  
Testing Protocol ◽  
Reflex Testing ◽  
Colorectal Cancer Patients

Abstract B45: Microsatellite instability among disenfranchised minority colorectal cancer patients

2014 ◽  
Author(s):  
Daniel A. Sussman ◽  
Shivali Berera ◽  
Peter Hosein ◽  
Feng Miao ◽  
Tulay Koru-Sengul ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Microsatellite Instability of Colorectal Cancer and Adenoma in Synchronous Multiple Colorectal Cancer Patients with Associated Extracolonic Malignancies

Surgery Today ◽  
2001 ◽  
Vol 31 (5) ◽  
pp. 405-409
Author(s):  
Eiji Ueda ◽  
Toshiaki Watanabe ◽  
Hironori Ishigami ◽  
Naoyuki Umetani ◽  
Shin Sasaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

A novel panel to detect microsatellite instability and concordance with clinical reference methods in colorectal cancer patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e22135-e22135
Author(s):  
Bart Claes ◽  
Rudi Rossau ◽  
Liesbeth Bernaerts ◽  
Els Fransen ◽  
Diether Lambrechts ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Reference Methods ◽  
Colorectal Cancer Patients

scholarly journals Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrea J. Savio ◽  
Darshana Daftary ◽  
Elizabeth Dicks ◽  
Daniel D. Buchanan ◽  
Patrick S. Parfrey ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Promoter Methylation ◽  
Colorectal Cancer Patients ◽  
Two Populations

Oncogenic mutations in colorectal cancer, indications for anatomical sites, and targeted intervention.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e22037-e22037
Author(s):  
Giovanni Corso ◽  
Valeria Pascale ◽  
Giuseppe Flauti ◽  
Daniele Marrelli ◽  
Franco Roviello
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Left Colon ◽  
Targeted Intervention ◽  
Right Colon ◽  
Right Colon Cancer ◽  
Oncogenic Mutations ◽  
Colorectal Cancer Patients

e22037 Background: Oncogenic mutations, such as KRAS, in colorectal cancer patients are considered standard molecular biomarkers that predict the clinical benefit for the targeted intervention with EGFR inhibitors. In addition, these mutations are associated with specific anatomical area in the colon tumor development, as BRAF mutations with the microsatellite instability. Methods: In this translational study we aim to assess the mutation frequencies of the EGFR [hotspot area and polyadenine deletions (A13_del)], KRAS, BRAFV600E, and PIK3CA oncogenes in a series of 280 colorectal cancer patients. Microsatellite instability phenotype is considered in this series. All patients' clinicopathological data were considered for statistical analysis and associations. Results: In this study, we verified multiple associations between oncogenic mutations and specified clinicopathological tumor features. Respectively, we identified the following significant results: 1) EGFR A13_deletions are associated with right colon carcinoma (22.2% vs. 3.3%; p<0.005), mucinous histotype (16% vs. 7.8%; p=0.042), G3 grading (19% vs. 7.3%; p=0.024) and microsatellite instability status (p<0.005); 2) PIK3CA mutations are related mucinous histotype (12% vs. 4.4%; p=0.021) 3) KRASG12 and KRASG13mutations are correlated respectively with the left (91.4% vs. 59.3%) and right (40.7% vs. 8.6%) colon cancer development (p<0.005), and finally 4) microsatellite instability is associated with right colon tumors (28.4% vs. 5.5%; p<0.005). Conclusions: Mostly, we verified a high frequency rate of the KRASG13 and EGFR A13_del oncogene mutations in right colon cancer; whereas KRASG12 codon mutation occurs more frequently in left colon cancers. In particular, we assessed that right colon cancer is associated with specific molecular characteristics, in comparison to left colon tumors. These evidences, in association with specific clinicopathological data, can delineate novel approaches for the colorectal cancer classification and targeted intervention.

Sign in / Sign up

Export Citation Format

Share Document