The hypotransferrinaemic mouse: Ultrastructural and laser microprobe analysis observations

1995 ◽  
Vol 177 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Theodore C. Iancu ◽  
Hanna Shiloh ◽  
Kishor B. Raja ◽  
Robert J. Simpson ◽  
Timothy J. Peters ◽  
...  
Keyword(s):  
Microprobe Analysis ◽  
Laser Microprobe

Laser microprobe analysis of brain aluminum in Alzheimer' disease

1993 ◽  
Vol 33 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Mark A. Lovell ◽  
William D. Ehmann ◽  
William R. Markesbery
Keyword(s):  
Alzheimer Disease ◽  
Microprobe Analysis ◽  
Laser Microprobe

Correlative Electron, Ion and Laser microprobe Analysis of Particle-Laden Alveolar Macrophages

1982 ◽  
Vol 40 ◽  
pp. 370-371
Author(s):  
R. W. Linton ◽  
J. D. Shelburne ◽  
D. S. Simons ◽  
P. Ingram
Keyword(s):  
Mass Spectrometry ◽  
Subcellular Localization ◽  
Alveolar Macrophage ◽  
Alveolar Macrophages ◽  
Microprobe Analysis ◽  
Energy Dispersive ◽  
Chemical Components ◽  
Ion Microprobe ◽  
X Ray ◽  
Laser Microprobe

The use of microanalytical techniques for the subcellular localization of chemical components, both physiologic and xenobiotic, is indicated to better characterize the pathophysiology of alveolar macrophage (AM) interactions with respirable particles. This study correlates conventional SEM/energy dispersive X-ray microanalysis (EDX) with ion microprobe (Cameca IMS-3f) and laser microprobe (Leybold-Heraeus LAMMA 500) mass spectrometry of AMs.

Laser microprobe mass spectrometry: A trend analysis

1992 ◽  
Vol 50 (2) ◽  
pp. 1558-1559
Author(s):  
Raimund Kaufmann ◽  
Bernhard Spengler
Keyword(s):  
Spatial Resolution ◽  
Microprobe Analysis ◽  
Ion Microprobe ◽  
High Brightness ◽  
Laser Microprobe Mass Spectrometry ◽  
Laser Microprobe ◽  
Ion Formation ◽  
Ion Probe ◽  
Key Aspects ◽  
Physical Principles

Within the search for ultimate frontieres in microprobe analysis, sensitivity, selectivity and spatial resolution are amongst the primary criteria to be assessed. During recent years laser microprobe and ion microprobe analysis have been the most promising and competing approaches which not only share a lot of features in common but, by their physical principles are both rather open to further general improvements and dedicated instrumentations.The term desorption for either laser- or particle-induced ion formation has become common use. Both principles are actually intensively explored especially with respect to produce organic ions by “soft” ionization. Some of the key aspects of such ion formation will be addressed with special emphasis on laser desorption.Both principles are equally well suited for spot probing and/or analytical imaging with spatial resolution in the sub 1 μm range. However, while SIMS ion probe techniques have meanwhile achieved some impressive improvements with respect to practical capabilities by introducing e.g. pulsed high brightness ion sources in combination with TOF-MS the state of the art in the available laser microprobe instruments has virtually remained the same since the first introduction of the LAMMA and LIMA instruments more than a decade ago.

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