p53 immunoreactivity and mutation of the p53 gene in smooth muscle tumours of the uterine corpus

1995 ◽  
Vol 177 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Michael D. Jeffers ◽  
Maura A. Farquharson ◽  
James A. Richmond ◽  
Ann Marie McNicol
Keyword(s):  
Smooth Muscle ◽  
P53 Gene ◽  
Uterine Corpus ◽  
P53 Immunoreactivity

Atypical Angiomyolipoma of Kidney in a Patient With Tuberous Sclerosis: A Case Report With p53 Gene Mutation Analysis

2005 ◽  
Vol 129 (5) ◽  
pp. 676-679 ◽  
Author(s):  
Linglei Ma ◽  
Diane Kowalski ◽  
Khurram Javed ◽  
Pei Hui
Keyword(s):  
Tuberous Sclerosis ◽  
P53 Gene ◽  
Epithelioid Cell ◽  
P53 Mutation ◽  
P53 Gene Mutation ◽  
Perivascular Epithelioid Cell ◽  
The Family ◽  
P53 Immunoreactivity ◽  
Gene Mutation Analysis ◽  
Hmb 45

Abstract Angiomyolipoma (AML) is the most common benign mesenchymal tumor of the kidney. It belongs to the family of perivascular epithelioid cell tumors and is typically composed of blood vessels, adipose tissue, and smooth muscle– like cells, which are characteristically positive for HMB-45. Results of recent studies suggest that p53 mutation may play an important role in AML progression. Here, we describe a locally destructive renal AML in a patient with tuberous sclerosis. The tumor consisted of mostly epithelioid cells with marked nuclear pleomorphism and frequent mitoses and was positive for HMB-45. The diagnosis of atypical epithelioid AML was made. Codon alteration in the p53 gene was not detected, despite focal p53 immunoreactivity and single nucleotide polymorphism at exon 6. Our finding indicates no definite link between p53 abnormalities and the atypical appearance of AML. To the best of our knowledge, this is the second renal AML case investigated for p53 mutations.

scholarly journals Perivascular epithelioid tumours (PEComas) of the gynaecological tract

2015 ◽  
Vol 68 (6) ◽  
pp. 418-426 ◽  
Author(s):  
Niamh Conlon ◽  
Robert A Soslow ◽  
Rajmohan Murali
Keyword(s):  
Smooth Muscle ◽  
Review Article ◽  
Classification Systems ◽  
Therapeutic Level ◽  
Diagnostic Challenge ◽  
Uterine Corpus ◽  
Rare Tumours

Perivascular epithelioid tumours (PEComas) of the gynaecological tract are rare tumours which were first recognised and diagnosed within the last 20 years. They represent a unique diagnostic challenge with regard to their accurate and reproducible distinction from more common entities such as smooth muscle tumours of the uterine corpus. In this review article, we trace the development of the concept of the PEComa tumour family, highlight what is known about extra-gynaecological tract PEComa at an immunohistochemical, molecular and therapeutic level and then present a summary of all reported cases of gynaecological tract PEComa to date. In the summary, we highlight rare subtypes of gynaecological tract PEComa and compare the performances of extant prognostic classification systems for malignancy in these tumours.

scholarly journals Transfer of Wild-Type p53 Gene Effectively Inhibits Vascular Smooth Muscle Cell Proliferation In Vitro and In Vivo

1998 ◽  
Vol 82 (2) ◽  
pp. 147-156 ◽  
Author(s):  
Yoshikazu Yonemitsu ◽  
Yasufumi Kaneda ◽  
Shinji Tanaka ◽  
Yutaka Nakashima ◽  
Kimihiro Komori ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
P53 Gene ◽  
Wild Type ◽  
Proliferation In Vitro

scholarly journals Diffuse Leiomyomatosis: Complete Myomectomy for Innumerable Small Nodules to Achieve Fertility Sparing and Childbearing

2019 ◽  
Vol 06 (S 01) ◽  
pp. S50-S57
Author(s):  
Ikuo Konishi
Keyword(s):  
Smooth Muscle ◽  
Caesarean Section ◽  
Young Women ◽  
Uterine Rupture ◽  
Rare Condition ◽  
Uterine Corpus ◽  
Safe Delivery ◽  
Longitudinal Incision ◽  
Fertility Sparing ◽  
Endometrial Cavity

AbstractDiffuse leiomyomatosis is a rare condition among benign smooth muscle neoplasms of the uterus, being defined as innumerable small myomatous nodules that mainly occur in the submucosal area. Young women with this disease suffer from menorrhagia, pains, and infertility. It is essential to perform extensive myomectomy after opening the endometrial cavity by a deep, median, longitudinal incision of the uterine corpus, followed by careful suture and reconstruction of the uterus for fertility spearing and childbearing in young women with this disease. So far, there have been no experiences of the uterine rupture during pregnancy even after such myomectomy, but Caesarean section is recommended for safe delivery.

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