In situ localization of type III and type IV collagen-expressing cells in human diabetic nephropathy

1994 ◽  
Vol 174 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Mohammed S. Razzaque ◽  
Takehiko Koji ◽  
Takashi Taguchi ◽  
Takashi Harada ◽  
Paul K. Nakane
Keyword(s):  
Diabetic Nephropathy ◽  
Type Iv Collagen ◽  
Type Iii ◽  
Type Iv

Synthesis of type III Collagen and type IV collagen by tubular epithelial cells in diabetic nephropathy

1995 ◽  
Vol 191 (11) ◽  
pp. 1099-1104 ◽  
Author(s):  
M.S. Razzaque ◽  
T. Koji ◽  
Y. Horita ◽  
M. Nishihara ◽  
T. Harada ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Epithelial Cells ◽  
Type Iv Collagen ◽  
Type Iii Collagen ◽  
Tubular Epithelial Cells ◽  
Type Iii ◽  
Type Iv

scholarly journals Serum Levels of Laminin, Type IV Collagen and Type III Procollagen Peptide as Markers for Detection of Metastasis

1994 ◽  
Vol 85 (12) ◽  
pp. 1263-1269 ◽  
Author(s):  
Kazuo Yudoh ◽  
Hisao Matsui ◽  
Masahiko Kanamori ◽  
Kazuo Ohmori ◽  
Haruo Tsuji ◽  
...  
Keyword(s):  
Type Iv Collagen ◽  
Serum Levels ◽  
Type Iii ◽  
Type Iv ◽  
Type Iii Procollagen ◽  
Type Iii Procollagen Peptide

scholarly journals The contribution of increased collagen synthesis to human glomerulosclerosis: a quantitative analysis of alpha 2IV collagen mRNA expression by competitive polymerase chain reaction.

1992 ◽  
Vol 176 (6) ◽  
pp. 1571-1576 ◽  
Author(s):  
E P Peten ◽  
L J Striker ◽  
M A Carome ◽  
S J Elliott ◽  
C W Yang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Polymerase Chain Reaction ◽  
Reverse Transcription ◽  
Collagen Synthesis ◽  
Type Iv Collagen ◽  
Chain Reaction ◽  
Collagen Mrna ◽  
Type Iv ◽  
Polymerase Chain

We previously reported that one of the main components of the sclerotic material in human glomerular diseases was type IV collagen. In this study we examined the contribution of increased synthesis to this process at the gene expression level. Sufficient material has not been available to study type IV collagen synthesis by normal or sclerotic glomeruli in humans. We took advantage of the availability of nephrectomy specimens from patients with renal carcinoma, and of the observation that approximately 50% of these patients develop varying degrees of glomerulosclerosis. We microdissected glomeruli from 10 patients and analyzed them using in situ reverse transcription coupled with polymerase chain reaction (PCR) analyses (in situ RT-PCR). alpha 2IV collagen mRNA, after reverse transcription into cDNA, was detected in all patients and appeared to be increased in those with glomerulosclerosis (n = 5). A competitive PCR assay was developed to quantitate this change. There was an average 3.7-fold increase in glomerular type IV collagen cDNA in patients with significant sclerosis. This change was not due to an increased number of glomerular cells. Thus, glomerulosclerosis in humans is associated with an elevation of glomerular type IV collagen gene expression, suggesting that increased synthesis of type IV collagen may represent one component of this process.

Procollagen type III N-peptide and type IV collagen 7S-domain in the sera of breast cancer patients

Surgery Today ◽  
1993 ◽  
Vol 23 (8) ◽  
pp. 682-686 ◽  
Author(s):  
Tatsuhiko Narita ◽  
Hiroomi Funahashi ◽  
Yasuyuki Satoh ◽  
Hiroshi Takagi
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Type Iv Collagen ◽  
Breast Cancer Patients ◽  
Type Iii ◽  
Procollagen Type ◽  
Type Iv ◽  
Type Iv Collagen 7S

Malotilate Prevents Accumulation of Type III pN-Collagen, Type IV Collagen, and Laminin in Carbon Tetrachloride-induced Pulmonary Fibrosis in Rats

1989 ◽  
Vol 139 (5) ◽  
pp. 1105-1111 ◽  
Author(s):  
Paavo Pääkkö ◽  
Raija Sormunen ◽  
Leila Risteli ◽  
Juha Risteli ◽  
Leena Ala-Kokko ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Pulmonary Fibrosis ◽  
Type Iv Collagen ◽  
Collagen Type ◽  
Collagen Type Iv ◽  
Type Iii ◽  
Type Iv
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