“Extraepithelial enterochromaffin cell—nerve-fibre complexes” in the normal human appendix, and in neurogenic appendicopathy

1982 ◽  
Vol 136 (3) ◽  
pp. 217-226 ◽  
Author(s):  
L. Auböck ◽  
M. Ratzenhofer
Keyword(s):  
Nerve Fibre ◽  
Enterochromaffin Cell ◽  
Neurogenic Appendicopathy ◽  
Normal Human ◽  
Human Appendix

scholarly journals Subserosal localization of myenteric ganglia in normal human appendix: immunostaining with neuronal and glial markers

2019 ◽  
Vol 119 (12) ◽  
pp. 743-746
Author(s):  
E. Kubikova ◽  
I. Sivakova ◽  
H. El Falougy ◽  
A. Perzelova
Keyword(s):  
Normal Human ◽  
Human Appendix ◽  
Myenteric Ganglia

scholarly journals The vermiform appendix impacts the risk of developing Parkinson’s disease

2018 ◽  
Vol 10 (465) ◽  
pp. eaar5280 ◽  
Author(s):  
Bryan A. Killinger ◽  
Zachary Madaj ◽  
Jacek W. Sikora ◽  
Nolwen Rey ◽  
Alec J. Haas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gastrointestinal Tract ◽  
Rural Areas ◽  
Lower Risk ◽  
Lewy Bodies ◽  
Vermiform Appendix ◽  
Healthy Human ◽  
Normal Human ◽  
Human Appendix

The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated α-synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed that removal of the appendix decades before PD onset was associated with a lower risk for PD, particularly for individuals living in rural areas, and delayed the age of PD onset. We also found that the healthy human appendix contained intraneuronal α-synuclein aggregates and an abundance of PD pathology–associated α-synuclein truncation products that are known to accumulate in Lewy bodies, the pathological hallmark of PD. Lysates of human appendix tissue induced the rapid cleavage and oligomerization of full-length recombinant α-synuclein. Together, we propose that the normal human appendix contains pathogenic forms of α-synuclein that affect the risk of developing PD.

scholarly journals Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa.

Gut ◽  
1986 ◽  
Vol 27 (6) ◽  
pp. 667-674 ◽  
Author(s):  
K Bjerke ◽  
P Brandtzaeg ◽  
T O Rognum
Keyword(s):  
Colon Mucosa ◽  
Normal Human ◽  
Human Appendix

Ultrastructural modification of cellular interactions in cancer tumor

1978 ◽  
Vol 36 (2) ◽  
pp. 318-319
Author(s):  
N. P. Dmitrieva
Keyword(s):  
Cancer Cells ◽  
Human Thyroid ◽  
Adjacent Cell ◽  
Main Role ◽  
Cellular Interactions ◽  
Electron Microscopic ◽  
Cancer Tumor ◽  
Normal Human ◽  
Characteristic Features

One of the most characteristic features of cancer cells is their ability to metastasia. It is suggested that the modifications of the structure and properties of cancer cells surfaces play the main role in this process. The present work was aimed at finding out what ultrastructural features apear in tumor in vivo which removal of individual cancer cells from the cell population can provide. For this purpose the cellular interactions in the normal human thyroid and cancer tumor of this gland electron microscopic were studied. The tissues were fixed in osmium tetroxide and were embedded in Araldite-Epon.In normal human thyroid the most common type of intercellular contacts was represented by simple junction formed by the parallelalignment of adjacent cell membranees leaving in between an intermembranes space 15-20 nm filled with electronlucid material (Fig. 1a). Sometimes in the basal part of cells dilatations of the intercellular space 40-50 nm wide were found (Fig. 1a). Here the cell surfaces may form single short microvilli.

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