Experimental pyelonephritis: The role of arterial narrowing in the production of the kidney of chronic pyelonephritis

1960 ◽  
Vol 80 (2) ◽  
pp. 249-258 ◽  
Author(s):  
R. H. Heptinstall ◽  
L. Michaels ◽  
W. Brumfitt
Keyword(s):  
Chronic Pyelonephritis ◽  
Experimental Pyelonephritis

The role of antibody in experimental pyelonephritis

1969 ◽  
Vol 97 (3) ◽  
pp. 513-525 ◽  
Author(s):  
Michael Kyriakos ◽  
Norman S. Ikari
Keyword(s):  
Experimental Pyelonephritis

Upper urinary tract infection

2015 ◽  
Author(s):  
Mark Harber
Keyword(s):  
Urinary Tract ◽  
Acute Pyelonephritis ◽  
Urinary Tract Obstruction ◽  
Reflux Nephropathy ◽  
Upper Urinary Tract ◽  
Chronic Pyelonephritis ◽  
Severe Illness ◽  
Emphysematous Pyelonephritis ◽  
Suppurative Infection

Pyelonephritis is a suppurative infection of the kidney most commonly due to bacterial infection that may be either acute or chronic. Acute pyelonephritis is usefully subdivided into uncomplicated and complicated. The term complicated pyelonephritis is associated with an abnormal urinary tract, obstruction, stones, immunocompromise, diabetes, pregnancy, or in practical terms any pyelonephritis resulting in severe illness. The distinction is important principally in terms of type, duration, and place of treatment.The clinical spectrum of acute pyelonephritis ranges from relatively mild illness to pyonephrosis and emphysematous pyelonephritis with a fulminant course and high mortality.The term chronic pyelonephritis has been used to describe kidneys damaged from multiple, recurrent, or partially treated episodes of infection, but for many of these examples ‘reflux nephropathy’ is a better description as the role of infection is not always clear. However chronic or very recurrent infections may be associated with diabetes, abnormal urinary tracts, and any cause of obstructed drainage. Chronic pyelonephritis is also an accurate description for the progressive ongoing destruction of the kidney that occurs in xanthogranulomatous pyelonephritis or malakoplakia.

Renal Tissue Damage After Experimental Pyelonephritis: Role of Anti-Oxidants and Selective Cyclooxygenase-2 Inhibitors

2009 ◽  
Vol 5 ◽  
pp. S22
Author(s):  
Serhat Gurocak ◽  
Iyimser Ure ◽  
Ahmet Cumaoglu ◽  
Ipek Isik Gonul ◽  
Ilker Sen ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Renal Tissue ◽  
Cyclooxygenase 2 ◽  
Experimental Pyelonephritis ◽  
Cyclooxygenase 2 Inhibitors

scholarly journals ROLE OF HUMAN DISKOIDIN DOMAIN RECEPTOR 1 IN THE PROGRESSION OF CHRONIC PYELONEPHRITIS IN CHILDREN

2017 ◽  
pp. 5-20
Author(s):  
N. N. Kaladze ◽  
E. I. Slobodyan
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Inverse Correlation ◽  
Chronic Pyelonephritis ◽  
Clinical Form ◽  
Discoidin Domain Receptors ◽  
Collagen Receptors ◽  
Mediators Of Inflammation ◽  
Tgf Β1

The purpose: to evaluate the role of collagen receptors Human Discoidin Domain Receptors (DDR1) as mediators of inflammation, proliferation and fibrosis in children with chronic pyelonephritis (CP), to reveal their relationship to the clinical form of the disease and the characteristics of its flow. Materials and methods: The levels of DDR1, transforming growth factor (TGF-β1), insulin-like growth factor (IGF-1) in the serum, β2 - microglobulin ( β2- MG) in the serum and urine were identified during the study of 40 children, ages 6 to 16 with CP in a state of clinical and laboratory remission. Results: Clinical and laboratory remission HP was associated with significant increased levels of DDR1 sera from long ill patients with frequent exacerbations, as well as 2-3 degree of activity last exacerbation, with family history. Found a strong inverse correlation between the levels of DDR1 and IGF-1, and the line with TGF-β1 and β2-MG of blood and urine. In patients with obstructive HP DDR1 level was significantly higher than in patients with non-obstructive clinical form. Conclusions: Increased serum DDR1 shows the progression of kidney damage with active fibrogenesis and inflammation in certain categories of patients with CP in a state of clinical and laboratory remission.

Renal Tissue Damage After Experimental Pyelonephritis: Role of Antioxidants and Selective Cyclooxygenase-2 Inhibitors

Urology ◽  
2010 ◽  
Vol 76 (2) ◽  
pp. 508.e1-508.e5 ◽  
Author(s):  
Serhat Gurocak ◽  
Iyimser Ure ◽  
Ahmet Cumaoglu ◽  
Ipek Isik Gonul ◽  
Ilker Sen ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Renal Tissue ◽  
Cyclooxygenase 2 ◽  
Experimental Pyelonephritis ◽  
Cyclooxygenase 2 Inhibitors
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