Role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis

1985 ◽  
Vol 4 (6) ◽  
pp. 540-543 ◽  
Author(s):  
P. M. Miniter ◽  
V. T. Andriole
Keyword(s):  
Reflux Nephropathy ◽  
Chronic Pyelonephritis

Upper urinary tract infection

2015 ◽  
Author(s):  
Mark Harber
Keyword(s):  
Urinary Tract ◽  
Acute Pyelonephritis ◽  
Urinary Tract Obstruction ◽  
Reflux Nephropathy ◽  
Upper Urinary Tract ◽  
Chronic Pyelonephritis ◽  
Severe Illness ◽  
Emphysematous Pyelonephritis ◽  
Suppurative Infection

Pyelonephritis is a suppurative infection of the kidney most commonly due to bacterial infection that may be either acute or chronic. Acute pyelonephritis is usefully subdivided into uncomplicated and complicated. The term complicated pyelonephritis is associated with an abnormal urinary tract, obstruction, stones, immunocompromise, diabetes, pregnancy, or in practical terms any pyelonephritis resulting in severe illness. The distinction is important principally in terms of type, duration, and place of treatment.The clinical spectrum of acute pyelonephritis ranges from relatively mild illness to pyonephrosis and emphysematous pyelonephritis with a fulminant course and high mortality.The term chronic pyelonephritis has been used to describe kidneys damaged from multiple, recurrent, or partially treated episodes of infection, but for many of these examples ‘reflux nephropathy’ is a better description as the role of infection is not always clear. However chronic or very recurrent infections may be associated with diabetes, abnormal urinary tracts, and any cause of obstructed drainage. Chronic pyelonephritis is also an accurate description for the progressive ongoing destruction of the kidney that occurs in xanthogranulomatous pyelonephritis or malakoplakia.

Chronic Pyelonephritis/Reflux Nephropathy

2018 ◽  
pp. 94
Author(s):  
Mitchell Tublin ◽  
Joel B. Nelson ◽  
Amir A. Borhani ◽  
Alessandro Furlan ◽  
Matthew T. Heller ◽  
...  
Keyword(s):  
Reflux Nephropathy ◽  
Chronic Pyelonephritis

Biomarkers in vesicoureteral reflux: an overview

2020 ◽  
Vol 14 (8) ◽  
pp. 683-696
Author(s):  
Flávia C Valério ◽  
Renata D Lemos ◽  
Ana L de C Reis ◽  
Letícia P Pimenta ◽  
Érica LM Vieira ◽  
...  
Keyword(s):  
Vesicoureteral Reflux ◽  
Renal Scarring ◽  
Reflux Nephropathy ◽  
Serum Levels ◽  
Cellular Adhesion ◽  
High Grade ◽  
Epigenetic Factors ◽  
Cellular Adhesion Molecules ◽  
Potential Biomarkers

Aim: This article aimed to review the role of cytokines, chemokines, growth factors and cellular adhesion molecules as biomarkers for vesicoureteral reflux (VUR) and reflux nephropathy (RN). Methods: We reviewed articles from 1979 onward by searching PubMed and Scopus utilizing the combination of words: ‘VUR’ or ‘RN’ and each one of the biomarkers. Results: Genetic, inflammatory, fibrogenic, environmental and epigenetic factors responsible for renal scarring need to be better understood. TGF-β, IL-10, IL-6, IL-8 and TNF seem to exert a role in VUR particularly in RN based on the current literature. Serum levels of procalcitonin have been also associated with high-grade VUR and RN. These molecules should be more intensively evaluated as potential biomarkers for renal scarring in VUR. Conclusion: Further studies are necessary to define which molecules will really be of utility in clinical decisions and as therapeutic targets for VUR and RN.

scholarly journals ROLE OF HUMAN DISKOIDIN DOMAIN RECEPTOR 1 IN THE PROGRESSION OF CHRONIC PYELONEPHRITIS IN CHILDREN

2017 ◽  
pp. 5-20
Author(s):  
N. N. Kaladze ◽  
E. I. Slobodyan
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Inverse Correlation ◽  
Chronic Pyelonephritis ◽  
Clinical Form ◽  
Discoidin Domain Receptors ◽  
Collagen Receptors ◽  
Mediators Of Inflammation ◽  
Tgf Β1

The purpose: to evaluate the role of collagen receptors Human Discoidin Domain Receptors (DDR1) as mediators of inflammation, proliferation and fibrosis in children with chronic pyelonephritis (CP), to reveal their relationship to the clinical form of the disease and the characteristics of its flow. Materials and methods: The levels of DDR1, transforming growth factor (TGF-β1), insulin-like growth factor (IGF-1) in the serum, β2 - microglobulin ( β2- MG) in the serum and urine were identified during the study of 40 children, ages 6 to 16 with CP in a state of clinical and laboratory remission. Results: Clinical and laboratory remission HP was associated with significant increased levels of DDR1 sera from long ill patients with frequent exacerbations, as well as 2-3 degree of activity last exacerbation, with family history. Found a strong inverse correlation between the levels of DDR1 and IGF-1, and the line with TGF-β1 and β2-MG of blood and urine. In patients with obstructive HP DDR1 level was significantly higher than in patients with non-obstructive clinical form. Conclusions: Increased serum DDR1 shows the progression of kidney damage with active fibrogenesis and inflammation in certain categories of patients with CP in a state of clinical and laboratory remission.

Role of reflux prevention in urinary diversion

1996 ◽  
Vol 63 (4) ◽  
pp. 522-526
Author(s):  
A. Tasca ◽  
L. Pizzol ◽  
C. Valotto
Keyword(s):  
High Pressure ◽  
Urinary Diversion ◽  
Clinical Experience ◽  
Reflux Nephropathy ◽  
Low Pressure ◽  
Objective Evidence ◽  
Continent Diversion

Considering current pathogenetical knowledge on reflux nephropathy and clinical experience with urinary diversions, it is impossible to arrive at a definitive conclusion on the necessity of reflux preventing techniques in urinary diversion. The decision has to take into account the apparent hazards of reflux in a given diversion and the apparent hazards of preventing reflux with that diversion. Whereas reflux prevention in high-pressure reservoirs and in continent diversion with cutaneous stomy is widely justified, there is no objective evidence to support the need for reflux prevention in urinary diversion with low-pressure bladder substitutes with sterile urine.

scholarly journals THE ROLE OF MATRIX METALLOPROTEINASES AND THEIR TISSUE INHIBITORS IN THE DEVELOPMENT OF COMPLICATIONS OF KIDNEY DISEASE IN CHILDREN

2015 ◽  
Vol 14 (3) ◽  
pp. 35-39 ◽  
Author(s):  
G. A. Sukhanova ◽  
A. A. Terent’eva ◽  
N. N. Kuvshinov
Keyword(s):  
Extracellular Matrix ◽  
Renal Function ◽  
Kidney Disease ◽  
Matrix Metalloproteinases ◽  
Chronic Pyelonephritis ◽  
Chronic Glomerulonephritis ◽  
Acute Glomerulonephritis ◽  
Healthy Children ◽  
Tissue Inhibitors

The relevance of studying the role of matrix metalloproteinases (MMP) and tissue inhibitors (TIMP) in the pathology of the urinary system is determined, by the significant prevalence, prone to recurrent course of kidney disease in children. It is known that MMP-1 has pro-inflammatory action, MMP-2 and MMP-9 inhibits inflammation. TIMP-1 and TIMP-2 restricted cleavage of collagen. Disbalance between MMP and TIMP accompanied by the accumulation of extracellular matrix, increases the risk of chronic renal failure.The purpose of the study – to assess the role of MMP and TIMP involved in the processes of inflammation and resulting to renal dysfunction in glomerulonephritis and pyelonephritis in children.Material and methods. Surveyed of 15 children with a diagnosis of acute glomerulonephritis, 25 – chronic glomerulonephritis, 40 – chronic obstructive secondary pyelonephritis and 20 healthy children. In the group of patients with chronic glomerulonephritis renal function was impaired in 10 patients with chronic pyelonephritis – in 20 patients. The content of MMP-1, -2, -9 and TIMP-1, TIMP-2 in the serum of children was determined by ELISA.Results. It was found that in acute and chronic glomerulonephritis in children increases the content of MMP-1, MMP-2 is almost not changed, while the content of MMP-9 is reduced, which characterizes the presence of inflammation. In chronic pyelonephritis in a more pronounced reduction of MMP-9, antiinflammatory. The most significant changes were found in patients with impaired renal function. In all groups of patients experienced an increase in the level of TIMP-1 and TIMP-2.Conclusion. Thus, increasing the level of tissue inhibitors, elevated levels of MMP-1, decreased MMP-9, contributes to the progression of the disease and the development of inflammation and the accumulation of extracellular matrix proteins of interstitial kidney tissue, resulting in sclerotic and fibrotic changes.

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