The effect of renal denervation on the blood pressure in experimental renal hypertension

1936 ◽  
Vol 42 (1) ◽  
pp. 141-154 ◽  
Author(s):  
W. Melville Arnott ◽  
Robert J. Kellar
Keyword(s):  
Blood Pressure ◽  
Renal Denervation ◽  
Renal Hypertension ◽  
Experimental Renal Hypertension

Mechanism of Early and Chronic Experimental Renal Hypertension as Tested by CCK-179

1956 ◽  
Vol 186 (1) ◽  
pp. 161-166 ◽  
Author(s):  
Irene H. Oyen
Keyword(s):  
Blood Pressure ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Renal Hypertension ◽  
Peripheral Resistance ◽  
Repeated Administration ◽  
Maximal Effect ◽  
Renal Effects ◽  
Experimental Renal Hypertension

The effects on blood pressure and renal clearances of a combination of dihydrogenated ergot alkaloids, CCK-179, were studied in normal dogs and dogs with experimental renal (Goldblatt) hypertension. The drug was observed to have a maximal effect at 0.012 mg/kg, about one twelfth to one sixteenth the dose recommended in the literature. In normal dogs the drug causes a slight fall in blood pressure, a moderate decrease in glomerular filtration rate (creatinine clearance) and a pronounced decrease in renal plasma flow (PAH clearance), hemodynamic effects resembling those seen in man. After repeated administration of the drug, the renal effects are of greater magnitude in these dogs. In hypertensive dogs, CCK-179 causes blood pressure to approach normal levels. In the early weeks of hypertension, the renal effects of the drug are similar to those seen in normals but as hypertension increases in duration up to 55 weeks, the decreases in filtration rate and plasma flow become progressively smaller. This could indicate that in chronic experimental renal hypertension the high peripheral resistance is maintained at least in part by increased activity of the sympathetic nervous system rather than by the action of the components of the renal humoral pressor system.

scholarly journals Blood pressure-independent effects of enhanced NO/cGMP signalling and gender on aortic remodelling in experimental renal hypertension

2009 ◽  
Vol 9 (Suppl 1) ◽  
pp. P19
Author(s):  
Bianca Grosz ◽  
Stephanie Krämer ◽  
Tanja Loof ◽  
Hans H Neumayer ◽  
Yingrui Wang-Rosenke ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Hypertension ◽  
Cgmp Signalling ◽  
Experimental Renal Hypertension ◽  
Pressure Independent ◽  
And Gender ◽  
Independent Effects

Salt, Frusemide and Renin in Severe Experimental Renal Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 129s-132s
Author(s):  
M. Fernandes ◽  
G. Onesti ◽  
R. Dykyj ◽  
R. Fiorentini ◽  
Anne B. Gould ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Early Phase ◽  
Sodium Intake ◽  
Renal Hypertension ◽  
Deficient Diet ◽  
Blood Pressure Elevation ◽  
High Sodium ◽  
High Sodium Intake ◽  
Experimental Renal Hypertension ◽  
High Sodium Diet

1. Sodium-deficient diet failed to alter development and maintenance of severe renal hypertension produced in the rat by ligation of the aorta between the renal arteries. 2. High sodium diet did not alter the early phase of this hypertension, but significantly decreased blood pressure elevation in the late phases. 3. The decrease in blood pressure produced by high sodium intake does not appear to be mediated by renin suppression. 4. Frusemide effectively reduced blood pressure and renin at all phases.

scholarly journals STUDIES ON EXPERIMENTAL HYPERTENSION

1943 ◽  
Vol 77 (4) ◽  
pp. 297-307 ◽  
Author(s):  
Harry Goldblatt ◽  
Joseph R. Kahn ◽  
Harvey A. Lewis
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Renal Hypertension ◽  
Renal Arteries ◽  
Experimental Hypertension ◽  
Long Duration ◽  
Humoral Mechanism ◽  
Main Renal Artery ◽  
Experimental Renal Hypertension ◽  
The One

Persistent hypertension has been produced in the goat and sheep by constriction of the main renal arteries. The presence or absence of accompanying uremia depends upon the degree of constriction of the renal arteries. In both sheep and goat, constriction of one main renal artery also caused elevation of the blood pressure which tended to persist longer than in the dog. Excision of the one kidney with main renal artery constricted resulted in a prompt (24 hours) return of the blood pressure to normal. In the animals with hypertension of long duration but without renal excretory insufficiency, (the "benign" phase) no significant arterio- or arteriolosclerosis developed as a result of the hypertension alone. In the animals that had both hypertension and renal excretory insufficiency, (the "malignant" phase) the typical terminal arteriolar lesions developed in many organs. These lesions consisted of necrosis and fibrinoid degeneration of arterioles and necrotizing arteriolitis which should not be confused with arteriolosclerosis. The same humoral mechanism which is responsible for experimental renal hypertension in the dog and other animals also obtains in the pathogenesis of experimental renal hypertension in the sheep and goat.

scholarly journals THE EFFECT OF HIGH PROTEIN DIETS ON EXPERIMENTAL RENAL HYPERTENSION

1941 ◽  
Vol 74 (6) ◽  
pp. 591-600 ◽  
Author(s):  
H. Philipsborn ◽  
L. N. Katz ◽  
S. Rodbard
Keyword(s):  
Blood Pressure ◽  
Renal Hypertension ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein ◽  
Experimental Renal Hypertension ◽  
High Protein Diets ◽  
Protein Diets

The effect of high and low protein diets were studied on fourteen dogs in twenty-four different experiments. In only two of these animals, both with moderate renal excretory failure, was a reversible rise in blood pressure elicited by a high protein diet. The possible mechanisms involved in meeting an increased excretory load are discussed.

Effect of chronic administration of propranolol on the blood pressure and heart weight in experimental renal hypertension

Life Sciences ◽  
1976 ◽  
Vol 18 (9) ◽  
pp. 967-970 ◽  
Author(s):  
Michael Fernandes ◽  
Gaddo Onesti ◽  
Roberto Fiorentini ◽  
Kwan Eun Kim ◽  
Charles Swartz
Keyword(s):  
Blood Pressure ◽  
Renal Hypertension ◽  
Chronic Administration ◽  
Heart Weight ◽  
Experimental Renal Hypertension

scholarly journals Reflex Control of Blood Pressure by the Right Subclavian Baroreceptor in Experimental Renal Hypertension of Rabbit

1966 ◽  
Vol 7 (6) ◽  
pp. 543-555 ◽  
Author(s):  
Hideo UEDA ◽  
Yasumi UCHIDA ◽  
Hisakazu YASUDA ◽  
Tadanao TAKEDA
Keyword(s):  
Blood Pressure ◽  
Renal Hypertension ◽  
Experimental Renal Hypertension ◽  
Reflex Control ◽  
The Right
Sign in / Sign up

Export Citation Format

Share Document