scholarly journals Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100

2020 ◽  
Vol 31 (6) ◽  
pp. 1270-1279 ◽  
Author(s):  
Fabrice Ofridam ◽  
Noureddine Lebaz ◽  
Émilie Gagnière ◽  
Denis Mangin ◽  
Abdelhamid Elaissari
Keyword(s):  
Ph Sensitive ◽  
Eudragit L100 ◽  
Eudragit E100

Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100

2005 ◽  
Vol 103 (1) ◽  
pp. 191-198 ◽  
Author(s):  
R.I. Moustafine ◽  
T.V. Kabanova ◽  
V.A. Kemenova ◽  
G. Van den Mooter
Keyword(s):  
Eudragit L100 ◽  
Interpolyelectrolyte Complexes ◽  
Eudragit E100

scholarly journals Development of pH-sensitive Insulin Nanoparticles using Eudragit L100-55 and Chitosan with Different Molecular Weights

2010 ◽  
Vol 11 (3) ◽  
pp. 1237-1242 ◽  
Author(s):  
Mitra Jelvehgari ◽  
Parvin Zakeri-Milani ◽  
Mohammad Reza Siahi-Shadbad ◽  
Badir Delf Loveymi ◽  
Ali Nokhodchi ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Molecular Weights ◽  
Eudragit L100

Preparation and Characterization of Insulin Nanoparticles Employing Chitosan and Poly(methylmethacrylate/methylmethacrylic acid) Copolymer

2006 ◽  
Vol 6 (9) ◽  
pp. 2874-2886 ◽  
Author(s):  
Ming-Guang Li ◽  
Wan-Liang Lu ◽  
Jian-Cheng Wang ◽  
Xuan Zhang ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Electrostatic Interactions ◽  
Release Kinetics ◽  
Ph Sensitive ◽  
Release Process ◽  
Eudragit L100 ◽  
Acid Copolymer ◽  
Nanoparticle System ◽  
Modeling Data

As most of polypeptides are marginally stable, a mild formulation procedure would be beneficial for the activities of these drugs. The objective of the present study was to develop a novel pH-sensitive nanoparticle system that was suitable for entrapment of hydrophilic insulin but without affecting its conformation. Chitosan was incorporated as a positively charged material, and one of the three poly(methylmethacrylate/methylmethacrylic acid) copolymers, consisting of Eudragit L100-55, L100, and S100, was used as a negatively charged polymer for preparation of three insulin nanoparticles, respectively. Three nanoparticles obtained were spherical. The mean diameters were in the range from 200 nm to 250 nm, and the entrapment efficiencies, from 50% to 70%. The surface analysis indicated that insulin was evenly distributed in the nanoparticles. Polymer ratio of chitosan to Eudragit was the factor which influenced the nanoparticles significantly. Characterization results showed that the electrostatic interactions existed, thus providing a mild formulation procedure which did not affect the chemical integrity and the conformation of insulin. In vitro release studies revealed that all three types of the nanoparticles exhibited a pH-dependant characteristic. The modeling data indicated that the release kinetics of insulin was nonlinear, and during the release process, the nanoparticles showed a polynomial swelling. On overall estimation, the insulin chitosan-Eudragit L100-55 nanoparticles may be better for the oral delivery. This new pH-sensitive nanoparticle formulation using chitosan and Eudragit L100-55 polymer may provide a useful approach for entrapment of hydrophilic polypeptides without affecting their conformation.

A Mechanism for Reversibly Pausing a Self-Immolation Cascade in Response to pH Changes

2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens
Keyword(s):  
Local Environment ◽  
Chemical Signals ◽  
Ph Sensitive ◽  
First Report ◽  
Ph Changes ◽  
Self Immolation

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>

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