scholarly journals pH‐Sensitive methacrylic acid–methyl methacrylate copolymer Eudragit L100 and dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate tri‐copolymer Eudragit E100

2019 ◽  
Vol 31 (3) ◽  
pp. 440-450 ◽  
Author(s):  
Coraline Sester ◽  
Fabrice Ofridam ◽  
Noureddine Lebaz ◽  
Emilie Gagnière ◽  
Denis Mangin ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Methacrylic Acid ◽  
Ph Sensitive ◽  
Butyl Methacrylate ◽  
Dimethylaminoethyl Methacrylate ◽  
Eudragit L100 ◽  
Acid Methyl ◽  
Eudragit E100 ◽  
Methacrylate Copolymer

scholarly journals Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor Loaded Chitosan Nanoparticles

2019 ◽  
Vol 14 (2) ◽  
pp. 132-140 ◽  
Author(s):  
Palanirajan V. Kumar ◽  
Marwan A. Abdelkarim Maki ◽  
Yeong S. Wei ◽  
Lee M. Tatt ◽  
Manogaran Elumalai ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Methacrylic Acid ◽  
Oral Delivery ◽  
Keratinocyte Growth Factor ◽  
Chitosan Nanoparticles ◽  
Serum Levels ◽  
Human Keratinocyte ◽  
Acid Methyl ◽  
Microscope Imaging ◽  
Methacrylate Copolymer

Background: Recombinant human keratinocyte growth factor (rHuKGF) has gained considerable attention by researchers as epithelial cells proliferating agent. Moreover, intravenous truncated rHuKGF (palifermin) has been approved by Food and Drug Administration (FDA) to treat and prevent chemotherapy-induced oral mucositis and small intestine ulceration. The labile structure and short circulation time of rHuKGF in-vivo are the main obstacles that reduce the oral bioactivity and dosage of such proteins at the target site. Objective: Formulation of methacrylic acid-methyl methacrylate copolymer-coated capsules filled with chitosan nanoparticles loaded with rHuKGF for oral delivery. Methods: We report on chitosan nanoparticles (CNPs) with diameter < 200 nm, prepared by ionic gelation, loaded with rHuKGF and filled in methacrylic acid-methyl methacrylate copolymercoated capsules for oral delivery. The pharmacokinetic parameters were determined based on the serum levels of rHuKGF, following a single intravenous (IV) or oral dosages using a rabbit model. Furthermore, fluorescent microscope imaging was conducted to investigate the cellular uptake of the rhodamine-labelled rHuKGF-loaded nanoparticles. The proliferation effect of the formulation on FHs 74 Int cells was studied as well by MTT assay. Results: The mucoadhesive and absorption enhancement properties of chitosan and the protective effect of methacrylic acid-methyl methacrylate copolymer against rHuKGF release at the stomach, low pH, were combined to promote and ensure rHuKGF intestinal delivery and increase serum levels of rHuKGF. In addition, in-vitro studies revealed the protein bioactivity since rHuKGFloaded CNPs significantly increased the proliferation of FHs 74 Int cells. Conclusion: The study revealed that oral administration of rHuKGF–loaded CNPs in methacrylic acid-methyl methacrylate copolymer-coated capsules is practically alternative to the IV administration since the absolute bioavailability of the orally administered rHuKGF–loaded CNPs, using the rabbit as animal model, was 69%. Fluorescent microscope imaging revealed that rhodaminelabelled rHuKGF-loaded CNPs were taken up by FHs 74 Int cells, after 6 hours’ incubation time, followed by increase in the proliferation rate.

scholarly journals Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100

2020 ◽  
Vol 31 (6) ◽  
pp. 1270-1279 ◽  
Author(s):  
Fabrice Ofridam ◽  
Noureddine Lebaz ◽  
Émilie Gagnière ◽  
Denis Mangin ◽  
Abdelhamid Elaissari
Keyword(s):  
Ph Sensitive ◽  
Eudragit L100 ◽  
Eudragit E100

Study on Adhesion and Biocompatibility of Copolymer of MMA-BMA-MAA for Coronary Stents Coatings

2005 ◽  
Vol 475-479 ◽  
pp. 2395-2398 ◽  
Author(s):  
Li-Li Tan ◽  
Ke Yang ◽  
Bing Chun Zhang ◽  
Yong Liang
Keyword(s):  
Methyl Methacrylate ◽  
Methacrylic Acid ◽  
Polymer Coatings ◽  
Metal Substrate ◽  
Coronary Stents ◽  
Polymer Composition ◽  
Butyl Methacrylate ◽  
Purification Method ◽  
Adhesion Properties ◽  
Copolymer Coating

Implantation of drug releasing coronary stents has been developed as an useful method for prevention of the restenosis in blood vessels. Copolymers of methyl methacrylate (MMA), butyl methacrylate (BMA) and methacrylic acid (MAA) were prepared as the coating polymer for drug releasing stent. The adhesion of the polymer with metal substrate and the biocompatibility were studied. Effect of the polymer composition on the adhesion between polymer coatings and metal substrate, as well as the effect of the polymer purification method on biocompatibility of the polymer, was studied. The results showed that the copolymer coating has good dry and wet adhesion properties, which can be improved by control of the polymer compositions. Biocompatibility of the prepared copolymer comes within the permission limit.

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