Fabrication of open‐porous PCL/PLA tissue engineering scaffolds and the relationship of foaming process, morphology, and mechanical behavior

2019 ◽  
Vol 30 (10) ◽  
pp. 2539-2548 ◽  
Author(s):  
Lixia Wang ◽  
Dongfang Wang ◽  
Yiping Zhou ◽  
Yantao Zhang ◽  
Qian Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mechanical Behavior ◽  
Tissue Engineering Scaffolds ◽  
Foaming Process ◽  
Relationship Of ◽  
The Relationship

APPLICATION OF BIOMECHANICS TO TISSUE ENGINEERING: A PERSONAL VIEW

2008 ◽  
Vol 08 (02) ◽  
pp. 153-160 ◽  
Author(s):  
BRUCE K. MILTHORPE
Keyword(s):  
Tissue Engineering ◽  
Mechanical Stimuli ◽  
Personal View ◽  
Tissue Engineering Scaffolds ◽  
Cellular Behavior ◽  
Cellular Biomechanics ◽  
Biological Studies ◽  
Biomechanical Stimuli ◽  
Relationship Of

Cellular biomechanics is an area of study that is receiving more attention as time progresses. The response of cells to their mechanical environment, including biomechanical stimuli, has far-reaching ramifications for the area of tissue engineering, especially for tissues designed to withstand mechanical loading (e.g. bone, cartilage, tendons and ligaments, and arteries). The effects of mechanical stimuli on cells are only recently being examined, and the potential role of mechanical stimuli in tissue engineering is still one that is largely ignored in the design of tissue engineering scaffolds. The relationship of mechanical properties of scaffolds or of mechanical stimuli to cell behavior is complex, but vital to the development of the field. Also, understanding the complex interplay of form and environment on cells involves an increase in our knowledge of how cells react to their total environment including mechanical stimuli and material properties. In order to improve tissue engineering outcomes, a nexus must be developed between the mechanical, biochemical, and biological studies of cellular behavior, in the context of extremely complex systems.

Solvent Free Fabrication of Biodegradable Porous Polymers

2004 ◽  
Author(s):  
Xiaoxi Wang ◽  
Wei Li ◽  
Vipin Kumar
Keyword(s):  
Tissue Engineering ◽  
Polymer System ◽  
Solvent Free ◽  
Porous Polymers ◽  
Tissue Engineering Scaffolds ◽  
Co2 Gas ◽  
Biochemical Sensors ◽  
Foaming Process ◽  
Cell Structures ◽  
Chemical Blowing Agents

Biodegradable porous polymers with interconnected pores of sub-micrometers to a few hundred micrometers find many applications in emerging technology areas such as tissue engineering, controlled drug delivery, and biochemical sensors. However, most of the current fabrication processes involve organic solvents and chemical blowing agents that may cause environmental concerns and leave residues harmful to biological cells. This paper presents a solvent free fabrication approach for biodegradable porous polymers. Ultrasound cavitation is introduced after the solid state foaming process to produce open cell structures. The material used in this study is polylactic acid (PLA). It belongs to a family of biodegradable polymers that can be used for tissue engineering scaffolds. In order to identify suitable conditions to apply ultrasound, a saturation and foaming study is conducted for the PLA-CO2 gas polymer system. The effects of various process variables are discussed.

scholarly journals Modeling and Simulation of a Selective Laser Foaming Process for Fabrication of Microliter Tissue Engineering Scaffolds

2017 ◽  
Vol 139 (11) ◽  
Author(s):  
JinGyu Ock ◽  
Wei Li
Keyword(s):  
Tissue Engineering ◽  
Laser Power ◽  
Biomedical Applications ◽  
Processing Parameters ◽  
Tissue Engineering Scaffolds ◽  
Element Analysis ◽  
Laser Absorption ◽  
Fea Model ◽  
Foaming Process ◽  
And Control

Selective laser foaming is a novel process that combines solid-state foaming and laser ablation to fabricate an array of microliter tissue engineering scaffolds on a polymeric chip for biomedical applications. In this study, a finite element analysis (FEA) model is developed to investigate the effect of laser processing parameters. Experimental results with biodegradable polylactic acid (PLA) were used for validation. It is found that foaming always occurs before ablation, and once it occurs, the temperature increases dramatically due to an enhanced laser absorption effect of the porous structure. The geometry of the fabricated scaffolds can be controlled by laser parameters. While the depth of scaffolds can be controlled by laser power and lasing time, the diameter is more effectively controlled by the laser power. The model developed in this study can be used to optimize and control the selective foaming process.

Construction and application of textile-based tissue engineering scaffolds: a review

2020 ◽  
Vol 8 (13) ◽  
pp. 3574-3600
Author(s):  
Yongjie Jiao ◽  
Chaojing Li ◽  
Laijun Liu ◽  
Fujun Wang ◽  
Xingxing Liu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Structure Function ◽  
Tissue Scaffolds ◽  
Tissue Engineering Scaffolds ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

This review discussed the structure–function relationship of textile-based scaffolds and appropriate textile technologies for application in certain kinds of tissue scaffolds.

Mechanical Behavior of the Rubber Blanket Used for Electrical Machine Hanging

2012 ◽  
Vol 501 ◽  
pp. 145-150
Author(s):  
Ti Kun Shan
Keyword(s):  
Stress Distribution ◽  
Mechanical Behavior ◽  
Compression Strength ◽  
Applied Load ◽  
Electrical Machine ◽  
Static Rigidity ◽  
Relationship Of ◽  
The Relationship

In order to get optimal properties of rubber blanket used for electrical machine hanging, FEM calculation is used to conduct stress distribution of rubber blanket to detect its rubber mechanical behavior, normal temperature static rigidity and compression strength, and detect the relationship of applied load and distortion. Ultimately, the simulative results are verified feasibly and their operating requirements are satisfied.

A Study of PLA Crystallization During Solid-State Foaming

2007 ◽  
Author(s):  
Xiaoxi Wang ◽  
Vipin Kumar ◽  
Wei Li
Keyword(s):  
Tissue Engineering ◽  
Solid State ◽  
Thermoplastic Polymer ◽  
Gas Sorption ◽  
Tissue Engineering Scaffolds ◽  
Foaming Process ◽  
Saturation Stage ◽  
Main Factors ◽  
Foaming Temperature ◽  
Process Ability

Polylactic acid (PLA) is a biodegradable semi-crystalline thermoplastic polymer that can be used in many applications such as tissue engineering scaffolds and packaging. The crystallinity of PLA is an important factor that affects its process-ability, mechanical strength, and biodegradability. The solid-state foaming of semi-crystalline PLA has been a subject of recent investigations. In this paper, crystallization through out the solid state foaming process was studied. It was found that the crystallization reaches the equilibrium once the gas sorption reaches the equilibrium. There are two main factors that will affect the PLA crystallization: gas sorption during the saturation stage and the heating and stretching during the foaming stage. Within the range of 2 to 5 MPa saturation pressures and 60 to 100 °C foaming temperatures, a maximum crystallinity of approx. 25% was observed in the foamed PLA. Effects of stretching and foaming temperature on crystallinity of foamed specimens were also investigated.

Research on the electrospun foaming process to fabricate three-dimensional tissue engineering scaffolds

2018 ◽  
Vol 135 (46) ◽  
pp. 46898 ◽  
Author(s):  
Peng Zhao ◽  
Mingyi Cao ◽  
Haibing Gu ◽  
Qing Gao ◽  
Neng Xia ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Three Dimensional ◽  
Tissue Engineering Scaffolds ◽  
Foaming Process

The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver
Keyword(s):  
Critical Points ◽  
Scleractinian Corals ◽  
Convincing Evidence ◽  
Early Triassic ◽  
Rugose Corals ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

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