New biodegradable bisphosphonate vinylic monomers and near infrared fluorescent nanoparticles for biomedical applications

2014 ◽  
Vol 25 (5) ◽  
pp. 499-506 ◽  
Author(s):  
Eran Gluz ◽  
Safra Rudnick-Glick ◽  
Dana M. Mizrahi ◽  
Ravit Chen ◽  
Shlomo Margel
Keyword(s):  
Biomedical Applications ◽  
Near Infrared ◽  
Fluorescent Nanoparticles

Stable Twisted Conformation Aza-BODIPY NIR-II Fluorescent Nanoparticles with Ultra-large Stokes Shift for Imaging-Guided Phototherapy

2022 ◽  
Author(s):  
Youliang Tian ◽  
Huiting Zhou ◽  
Quan Cheng ◽  
Huiping Dang ◽  
Hongyun Qian ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Great Promise ◽  
Deep Penetration ◽  
Fluorescent Nanoparticles ◽  
Spatiotemporal Resolution ◽  
Large Stokes Shift

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise for in vivo imaging and imaging-guided phototherapy with deep penetration and high spatiotemporal resolution. It is very...

Near-Infrared Emitting Dual-Stimuli-Responsive Carbon Dots from Endogenous Bile Pigments

Nanoscale ◽  
2021 ◽  
Author(s):  
Parinaz Fathi ◽  
Parikshit Moitra ◽  
Madeleine M. McDonald ◽  
Mandy Brigitte Esch ◽  
Dipanjan Pan
Keyword(s):  
Surface Modification ◽  
Carbon Dots ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Bile Pigments ◽  
Careful Selection ◽  
Stimuli Responsive ◽  
Carbon Dot ◽  
Surface Modification Techniques ◽  
Selection Of

Carbon dots are biocompatible nanoparticles suitable for a variety of biomedical applications. Careful selection of carbon dot precursors and surface modification techniques has allowed for the development of carbon dots...

scholarly journals Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 327 ◽  
Author(s):  
Kamil Rahme ◽  
Nazih Dagher
Keyword(s):  
Biomedical Applications ◽  
Near Infrared ◽  
Blood Stream ◽  
Biocompatible Polymers ◽  
Low Molecular Weight ◽  
Blood Components ◽  
Vast Number ◽  
Macrophage Phagocytosis ◽  
Sterical Hindrance

Polyethylene glycol (PEG) is one of the most frequently used polymers for coating nanocarriers to enhance their biocompatibility, hydrophilicity, stability, and biodegradability. PEG is now considered to be among the best biocompatible polymers. It offers sterical hindrance against other nanoparticles and blood components such as opsonin, preventing their macrophage phagocytosis and resulting in a prolonged circulation time in blood stream, consequently a ‘stealth character’ in vivo. Therefore, PEG has a very promising future for the development of current therapeutics and biomedical applications. Moreover, the vast number of molecules that PEG can conjugate with might enhance its ability to have an optimistic perspective for the future. This review will present an update on the chemistry used in the modern conjugation methods for a variety of PEG conjugates, such methods include, but are not limited to, the synthesis of targeting PEG conjugates (i.e., Peptides, Folate, Biotin, Mannose etc.), imaging PEG conjugates (i.e., Coumarin, Near Infrared dyes etc.) and delivery PEG conjugates (i.e., doxorubicin, paclitaxel, and other hydrophobic low molecular weight drugs). Furthermore, the type of nanoparticles carrying those conjugates, along with their biomedical uses, will be briefly discussed.

Carbon dots with red/near-infrared emissions and their intrinsic merits for biomedical applications

Carbon ◽  
2020 ◽  
Vol 167 ◽  
pp. 322-344 ◽  
Author(s):  
Hui Ding ◽  
Xuan-Xuan Zhou ◽  
Ji-Shi Wei ◽  
Xiao-Bing Li ◽  
Bo-Tao Qin ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Infrared Emissions

scholarly journals Synthesis and Biomedical Applications of Lanthanides-Doped Persistent Luminescence Phosphors With NIR Emissions

2020 ◽  
Vol 8 ◽  
Author(s):  
Xinyuan Qin ◽  
Jie Wang ◽  
Quan Yuan
Keyword(s):  
Energy Transfer ◽  
Light Scattering ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Crystal Defects ◽  
Research Progress ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Reduced Light ◽  
Transfer Channels

Persistent luminescence phosphors (PLPs) are largely used in biomedical areas owing to their unique advantages in reducing the autofluorescence and light-scattering interference from tissues. Moreover, PLPs with long-lived luminescence in the near-infrared (NIR) region are able to be applied in deep-tissue bioimaging or therapy due to the reduced light absorption of tissues in NIR region. Because of their abundant election levels and energy transfer channels, lanthanides are widely doped in PLPs for the generation of NIR persistent emissions. In addition, the crystal defects introduced by lanthanides-doping can serves as charge traps in PLPs, which contributes to the enhancement of persistent luminescence intensity and the increase of persistent time. In this paper, the research progress in the synthesis and biomedical applications of lanthanides-doped PLPs with NIR emissions are systematically summarized, which can provide instructions for the design and applications of PLPs in the future.

scholarly journals Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers

Nanomaterials ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1360 ◽  
Author(s):  
Asma Khalid ◽  
Romina Norello ◽  
Amanda N. Abraham ◽  
Jean-Philippe Tetienne ◽  
Timothy J. Karle ◽  
...  
Keyword(s):  
Magnesium Oxide ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Cultured Cells ◽  
Infrared Emission ◽  
Fluorescent Nanoparticles ◽  
Short Term ◽  
Fluorescent Markers

Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial and in-house ball-milled MgO nanoparticles, respectively. As such, the NPs have been successfully integrated into cultured cells and photostable bright in vitro emission from NPs was recorded and analyzed. We expect that numerous biotechnological and medical applications will emerge as this nanomaterial satisfies all criteria for short-term in vivo imaging.

Fluorescence Studies of Fe3O4-Au Hybrid Nanoparticles

MRS Advances ◽  
2018 ◽  
Vol 3 (14) ◽  
pp. 725-731
Author(s):  
Raheeb Alsaidi ◽  
Blawal Chaudhry ◽  
Juhayer S. Uddin ◽  
Andrew Nunez ◽  
Arkadiusz Baginski ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Biomedical Applications ◽  
Nir Spectroscopy ◽  
Life Time ◽  
Solution Phase ◽  
Hybrid Nanoparticles ◽  
Fluorescent Nanoparticles ◽  
Fluorescent Properties ◽  
Fluorescence Studies ◽  
Phase Chemical

ABSTRACTMagnetic and fluorescent nanoparticles are widely studied in biomedical research such as drug delivery, imaging, etc. Hybrid nanoparticles combining both magnetic and fluorescent properties are particularly interesting. In this manuscript, we report a recent study on Fe3O4-Au hybrid nanoparticles displaying fluorescence. Fe3O4-Au hybrid nanoparticles were synthesized via solution phase chemical reaction in inert N2 atmosphere. The synthesized hybrid nanoparticles were characterized by UV-Vis-NIR spectroscopy and fluorescence spectroscopy, XRD, TEM, etc. The optimal synthesis condition yields stable, uniform hybrid nanoparticles without impurities. The correlation between fluorescent life- time and sizes, compositions, shapes of hybrid nanoparticles was discussed. Biomedical applications of synthesized hybrid nanoparticles, utilizing their fluorescent and magnetic properties, are still undergoing.

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