scholarly journals Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives

ChemistryOpen ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 176-182
Author(s):  
Qi Wan ◽  
Yan Deng ◽  
Yaoqing Huang ◽  
Zhihui Yu ◽  
Chunli Wang ◽  
...  
Keyword(s):  
Estradiol Derivatives ◽  
Antitumor Evaluation

scholarly journals Cover Feature: Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives (ChemistryOpen 2/2020)

ChemistryOpen ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 98-98
Author(s):  
Qi Wan ◽  
Yan Deng ◽  
Yaoqing Huang ◽  
Zhihui Yu ◽  
Chunli Wang ◽  
...  
Keyword(s):  
Estradiol Derivatives ◽  
Antitumor Evaluation

Cytotoxic activity of proflavine diureas: Synthesis, antitumor, evaluation and DNA binding properties of 1′,1″-(acridin-3,6-diyl)-3′,3″-dialkyldiureas

2008 ◽  
Vol 16 (7) ◽  
pp. 3976-3984 ◽  
Author(s):  
Mária Kožurková ◽  
Danica Sabolová ◽  
Ladislav Janovec ◽  
Jaromír Mikeš ◽  
Ján Koval’ ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Binding Properties ◽  
Dna Binding Properties ◽  
Antitumor Evaluation

Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues

2012 ◽  
Vol 22 (5) ◽  
pp. 2360-2375 ◽  
Author(s):  
Adel S. El-Azab ◽  
Amer M. Alanazi ◽  
Naglaa I. Abdel-Aziz ◽  
Ibrahim A. Al-Suwaidan ◽  
Magda A. A. El-Sayed ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Molecular Modeling Study ◽  
Structural Analogues ◽  
Antitumor Evaluation ◽  
Modeling Study

Evaluation of Paclitaxel Nanocrystals In Vitro and In Vivo

Drug Research ◽  
2017 ◽  
Vol 68 (04) ◽  
pp. 205-212 ◽  
Author(s):  
Wanqing Li ◽  
Zhiguo Li ◽  
Lisha Wei ◽  
Aiping Zheng
Keyword(s):  
Drug Concentration ◽  
Antitumor Effects ◽  
High Drug ◽  
High Drug Concentration ◽  
Low Toxicity ◽  
Nanoparticle Drug Delivery ◽  
Antitumor Evaluation ◽  
Mcf 7

AbstractWe created a novel paclitaxel (PTX) nanoparticle drug delivery system and compared this to acommercial injection preparation to evaluate the antitumor effects for both formulations in vivo and in vitro.PTXnanocrystals were 194.9 nm with potential of −29.6 mV. Cytotoxicity tests indicated that both formulations had similar effects and cytotoxicity was dose- and time-dependent.Pharmacodynamics indicated that the drug concentration at the tumor was greater with PTX nanocrystals compared to commercial injection (P<0.01) and that drug accumulated more and for a longer duration. In vivo antitumor evaluation indicated significant antitumor effects and low toxicity of PTX nanocrystals. Moreover, bioimaging indicated that the PTX retention time in MCF-7-bearing mice was longer, especially at the tumor site, and this high drug concentration was maintained for a long time.Overall, PTX nanocrystalsare feasible and superior to traditional injection formulation chemotherapy.

scholarly journals Synthesis, Antitumor Evaluation and Molecular Docking of New Morpholine Based Heterocycles

Molecules ◽  
2017 ◽  
Vol 22 (7) ◽  
pp. 1211 ◽  
Author(s):  
Zeinab Muhammad ◽  
Mastoura Edrees ◽  
Rasha Faty ◽  
Sobhi Gomha ◽  
Seham Alterary ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antitumor Evaluation

ChemInform Abstract: The Synthesis and Antitumor Evaluation of Unsymmetrical Bis-imides.

ChemInform ◽  
2010 ◽  
Vol 28 (20) ◽  
pp. no-no
Author(s):  
R. J. CHERNEY ◽  
S. G. SWARTZ ◽  
A. D. PATTEN ◽  
E. AKAMIKE ◽  
J.-H. SUN ◽  
...  
Keyword(s):  
Antitumor Evaluation
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