scholarly journals Improvements in glycemic control after gastric bypass occur despite persistent adipose tissue inflammation

Obesity ◽  
2016 ◽  
Vol 24 (7) ◽  
pp. 1438-1445 ◽  
Author(s):  
Mario Kratz ◽  
Derek K. Hagman ◽  
Jessica N. Kuzma ◽  
Karen E. Foster-Schubert ◽  
Chun P. Chan ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Adipose Tissue ◽  
Glycemic Control ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Luis D'Marco ◽  
Valery Morillo ◽  
José Luis Gorriz ◽  
María K. Suarez ◽  
Manuel Nava ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glycemic Control ◽  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Renal Diseases ◽  
Diabetic Patients ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
First Line Therapy ◽  
Anti Inflammatory

Background. Over the last few years, the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) has increased substantially in medical practice due to their documented benefits in cardiorenal and metabolic health. In this sense, and in addition to being used for glycemic control in diabetic patients, these drugs also have other favorable effects such as weight loss and lowering blood pressure, and more recently, they have been shown to have cardio and renoprotective effects with anti-inflammatory properties. Concerning the latter, the individual or associated use of these antihyperglycemic agents has been linked with a decrease in proinflammatory cytokines and with an improvement in the inflammatory profile in chronic endocrine-metabolic diseases. Hence, these drugs have been positioned as first-line therapy in the management of diabetes and its multiple comorbidities, such as obesity, which has been associated with persistent inflammatory states that induce dysfunction of the adipose tissue. Moreover, other frequent comorbidities in long-standing diabetic patients are chronic complications such as diabetic kidney disease, whose progression can be slowed by SGLT2i and/or GLP-1RA. The neuroendocrine and immunometabolism mechanisms underlying adipose tissue inflammation in individuals with diabetes and cardiometabolic and renal diseases are complex and not fully understood. Summary. This review intends to expose the probable molecular mechanisms and compile evidence of the synergistic or additive anti-inflammatory effects of SGLT2i and GLP-1RA and their potential impact on the management of patients with obesity and cardiorenal compromise.

scholarly journals Regular exercise reduces adipose tissue inflammation and improves glycemic control in Western diet‐fed mice despite hyperendothelinemia

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Thomas J Jurrissen ◽  
Zachary I Grunewald ◽  
James R Ball ◽  
Francisco I Ramirez‐Perez ◽  
Makenzie L Woodford ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glycemic Control ◽  
Western Diet ◽  
Regular Exercise ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

2020 ◽  
Vol 134 (12) ◽  
pp. 1403-1432 ◽  
Author(s):  
Manal Muin Fardoun ◽  
Dina Maaliki ◽  
Nabil Halabi ◽  
Rabah Iratni ◽  
Alessandra Bitto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Therapeutic Agents ◽  
Adipose Tissue Inflammation ◽  
Cellular Mechanisms ◽  
Tissue Inflammation ◽  
Cholesterol Levels ◽  
Naturally Occurring ◽  
Pro Inflammatory Cytokines

Abstract Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.

The Effect of Saxagliptin on Adipose Tissue Inflammation in Overweight and Obese Nondiabetic Subjects

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1212-P ◽  
Author(s):  
JURAJ KOSKA ◽  
TRACY OSREDKAR ◽  
D'SOUZA KAREN ◽  
SANDEEP SINHA ◽  
CHRISTIAN MEYER ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

Insulin Sensitizing Effects of Vitamin D Mediated through Reduced Adipose Tissue Inflammation and Fibrosis

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 39-OR
Author(s):  
ERIC LONTCHI-YIMAGOU ◽  
SONA KANG ◽  
KEHAO ZHANG ◽  
AKANKASHA GOYAL ◽  
JEE YOUNG YOU ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

2032-P: Adipose Tissue Inflammation after Weight Loss

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2032-P
Author(s):  
ANA E. ESPINOSA DE YCAZA ◽  
ESBEN SØNDERGAARD ◽  
MARIA MORGAN-BATHKE ◽  
DANAE A. DELIVANIS ◽  
BARBARA G. CARRANZA LEON ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation
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