scholarly journals Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations

Obesity ◽  
2016 ◽  
Vol 24 (6) ◽  
pp. 1389-1396 ◽  
Author(s):  
Gerben Hulsegge ◽  
Gerrie-Cor M. Herber-Gast ◽  
Annemieke M.W. Spijkerman ◽  
H. Susan ◽  
J. Picavet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Age Related ◽  
Markers Of Oxidative Stress ◽  
Age Related Changes

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 ◽  
Vol 3 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Kathryn Z Guyton ◽  
Myriani Gorospe ◽  
Xiantao Wang ◽  
Yolanda D Mock ◽  
Gertrude C Kokkonen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Age Related ◽  
Mitogen Activated Protein ◽  
Age Related Changes

Age-related changes in apoptosis in rat hippocampus induced by oxidative stress

2011 ◽  
Vol 87 (2) ◽  
pp. 98-104 ◽  
Author(s):  
N Uysal ◽  
K Tugyan ◽  
I Aksu ◽  
S Ozbal ◽  
D Ozdemir ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hippocampus ◽  
Age Related ◽  
Age Related Changes

Cytokine modulation, oxidative stress and thymic dysfunctions: Role of age-related changes in the experimental Trypanosoma cruzi infection

Cytokine ◽  
2018 ◽  
Vol 111 ◽  
pp. 88-96 ◽  
Author(s):  
Rafaela Pravato Colato ◽  
Vânia Brazão ◽  
Gabriel Tavares do Vale ◽  
Fabricia Helena Santello ◽  
Pedro Alexandre Sampaio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trypanosoma Cruzi ◽  
Cytokine Modulation ◽  
Age Related ◽  
Cruzi Infection ◽  
Age Related Changes

scholarly journals Dietary Supplementation with Beta-Cryptoxanthin (BCX) Protects Against Light-Induced Retinal Damage

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 126-126
Author(s):  
Deshanie Rai ◽  
Kazim Sahin ◽  
Kazim Sahin ◽  
Emre Sahin ◽  
Mehmet Tuzcu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Angiogenic Factor ◽  
Retinal Damage ◽  
Waste Products ◽  
Health Technologies ◽  
Retinal Tissue ◽  
Age Related ◽  
Markers Of Oxidative Stress

Abstract Objectives The retinal pigment epithelium (RPE) regulates the transport of nutrients and waste products to and from the retina and protects against light and oxidative stress. Structural or physiological dysfunction of RPE leads to retinal conditions such as age-related eye disease (ARED). It is well-established that artificial and natural light is an important factor in the progression of ARED as it can induce oxidative damage and photochemical lesions. Recently, the use of LED in general lighting has raised concerns regarding the effects of this light source on the RPE. The goal was to investigate whether beta-cryptoxanthin, an efficient pro-vitamin A carotenoid can exert protective effects against LED-induced RPE cell damage. Methods Rats were fed with BCX for 4 weeks at a dose of 2 and 4 mg/kg body weight followed by retinal damage by exposing the eye to bright LED light for 48 hrs. Commercially available white LED sources, which are widely used in rat housing studies was used to induce retinal damage. Animals were sacrificed at the end of the study and retinal tissue and blood samples were collected and evaluated for retinal damage and markers of oxidative stress. Results BCX supplementation significantly reduced retinal damage as demonstrated by histopathology measurements including total retinal thickness, outer nuclear layer thickness, and swelling. Similarly, markers of oxidative stress including serum and retinal tissue levels of malondialdehyde, superoxide dismutase, glutathione peroxidase, and catalase were beneficially modulated by BCX supplementation. In parallel, BCX supplementation reduced inflammatory markers (IL-1β, IL-6, NF-κB), angiogenic factor VEGF, apoptotic proteins (Caspase-3, GAP43, GFAP, NCAM, HO-1) and mitochondrial stress markers (ATF4, ATF6, Grp78, Grp97) in retinal tissue. Conclusions Our study supports that oral supplementation of BCX dose-dependently exerts a protective effect against retinal damage induced by high-intensity light in a rat model by reducing oxidative stress, inflammation, angigogenesis and protection against mitochondrial DNA damage. BCX dietary intakes and supplementation throughout all stages of life can help protect against ARED that may start early in life. Funding Sources OmniActive Health Technologies.

scholarly journals Vitreous Antioxidants, Degeneration, and Vitreo-Retinopathy: Exploring the Links

Antioxidants ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 7 ◽  
Author(s):  
Emmanuel Ankamah ◽  
J. Sebag ◽  
Eugene Ng ◽  
John M. Nolan
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Present Article ◽  
Vitreous Body ◽  
Enzymatic Antioxidants ◽  
Age Related ◽  
Growing Body ◽  
Clinically Significant ◽  
Age Related Changes

The transparent vitreous body, which occupies about 80% of the eye’s volume, is laden with numerous enzymatic and non-enzymatic antioxidants that could protect the eye from oxidative stress and disease. Aging is associated with degeneration of vitreous structure as well as a reduction in its antioxidant capacity. A growing body of evidence suggests these age-related changes may be the precursor of numerous oxidative stress-induced vitreo-retinopathies, including vision degrading myodesopsia, the clinically significant entoptic phenomena that can result from advanced vitreous degeneration. Adequate intravitreal antioxidant levels may be protective against vitreous degeneration, possibly preventing and even improving vision degrading myodesopsia as well as mitigating various other vitreo-retinopathies. The present article is, therefore, a review of the different antioxidant molecules within vitreous and the inter-relationships between vitreous antioxidant capacity and degeneration.

scholarly journals Markers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans

2010 ◽  
Vol 3 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Kanti Bhooshan Pandey ◽  
Syed Ibrahim Rizvi
Keyword(s):  
Oxidative Stress ◽  
Aging Process ◽  
Biological Process ◽  
Related Phenomenon ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Age Related ◽  
General Decline ◽  
Markers Of Oxidative Stress ◽  
Probability Of Death

Aging is an inevitable universal biological process, which can be characterized by a general decline in physiological function with the accumulation of diverse adverse changes and increased probability of death. Among several theories, oxidative stress/free radical theory offers the best mechanistic elucidation of the aging process and other age-related phenomenon. In the present paper, we discuss the aging process and have focused on the importance of some reliable markers of oxidative stress which may be used as biomarkers of the aging process.

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