scholarly journals Prefrontal cortex infusion of beta‐hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant‐like effects in a rodent model of depression

2020 ◽  
Vol 40 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Naofumi Kajitani ◽  
Masaaki Iwata ◽  
Akihiko Miura ◽  
Kyohei Tsunetomi ◽  
Takehiko Yamanashi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nlrp3 Inflammasome ◽  
Rodent Model ◽  
Beta Hydroxybutyrate

scholarly journals Stress increases blood beta‐hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model

2021 ◽  
Author(s):  
Tsuyoshi Nishiguchi ◽  
Masaaki Iwata ◽  
Naofumi Kajitani ◽  
Akihiko Miura ◽  
Ryoichi Matsuo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Rodent Model ◽  
Beta Hydroxybutyrate ◽  
Nlrp3 Activity

Transcutaneous auricular vagal nerve stimulation inhibits P2X7R expression in limbic brain regions and reverses depression-like behavior in Zucker diabetic fatty rats

2020 ◽  
Author(s):  
Yutian Yu ◽  
Xun He ◽  
Yu Wang ◽  
Jinling Zhang ◽  
Chunzhi Tang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nerve Stimulation ◽  
Cingulate Cortex ◽  
Brain Regions ◽  
Rodent Model ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Depressive Effect ◽  
Zucker Diabetic Fatty Rats ◽  
Zdf Rats

Abstract Background Previous studies confirmed that Zucker diabetic fatty rats (ZDF, fa/fa) develop type 2 diabetes (T2D) with depression-like behavior innately, and transcutaneous auricular vagal nerve stimulation (taVNS) was found to have anti-diabetic and anti-depressive effect in ZDF rats. However, there is still a lack of molecular-biological evidence that ZDF rats are a good rodent model of depression, and how does taVNS take the anti-depressive effect to the ZDF rats. P2 × 7R, a purinergic receptor most-related to inflammation and depression, is found to be elevated in depressed brains and is gradually considered as a potential therapeutic target for depression. Methods We deployed taVNS and transcutaneous none vagal nerve stimulation (tnVNS) to ZDF rats. We applied forced swimming test (FST) to evaluate to the depression-like behavior of the rats. We used Western blot to test the P2 × 7R expression in the hypothalamus, amygdala, hippocampus, prefrontal cortex, and cingulate cortex of the rats. Furthermore, we used immunohistochemical staining to colocalize the P2 × 7R expressing cells in the ZDF rats’ brains. Results We found that compared with their lean littermates (ZL rats), naïve ZDF rats developed depression-like behavior innately with elevated P2 × 7R expression in their limbic brain regions (hypothalamus, amygdala, hippocampus, prefrontal cortex, and cingulate cortex); and taVNS but not tnVNS inhibited the P2 × 7R expression in their limbic brain regions and reversed the depression-like behavior. Moreover, P2 × 7R was found majorly expressing in astrocytes and microglia of ZDF rats. Conclusions ZDF rats are a good rodent model of depression, and taVNS plays an anti-depressive effect in ZDF rats by inhibiting glial P2 × 7R expression in their limbic brain regions.

scholarly journals The hippocampus, medial prefrontal cortex, and selective memory retrieval: Evidence from a rodent model of the retrieval-induced forgetting effect

Hippocampus ◽  
2014 ◽  
Vol 24 (9) ◽  
pp. 1070-1080 ◽  
Author(s):  
Jade Q. Wu ◽  
Greg J. Peters ◽  
Pedro Rittner ◽  
Thomas A. Cleland ◽  
David M. Smith
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Memory Retrieval ◽  
Rodent Model ◽  
Induced Forgetting
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