scholarly journals The hippocampus, medial prefrontal cortex, and selective memory retrieval: Evidence from a rodent model of the retrieval-induced forgetting effect

Hippocampus ◽  
2014 ◽  
Vol 24 (9) ◽  
pp. 1070-1080 ◽  
Author(s):  
Jade Q. Wu ◽  
Greg J. Peters ◽  
Pedro Rittner ◽  
Thomas A. Cleland ◽  
David M. Smith
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Memory Retrieval ◽  
Rodent Model ◽  
Induced Forgetting

scholarly journals Early-life blockade of NMDA receptors induces epigenetic abnormalities in the adult medial prefrontal cortex: possible involvement in memory impairment in trace fear conditioning

2019 ◽  
Vol 237 (1) ◽  
pp. 231-248 ◽  
Author(s):  
Joachim Latusz ◽  
Marzena Maćkowiak
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptors ◽  
Fear Conditioning ◽  
Medial Prefrontal Cortex ◽  
Memory Retrieval ◽  
Early Life ◽  
Histone H3 ◽  
Protein Levels ◽  
Trace Fear Conditioning ◽  
Trace Fear

Abstract Rationale Several findings indicate that early-life dysfunction of N-methyl-d-aspartate (NMDA) receptors might cause schizophrenia-like abnormalities in adulthood that might be induced by impairments in epigenetic regulation. Objectives In the present study, we investigated whether postnatal blockade of NMDA receptors (within the first 3 weeks of life) by the competitive antagonist CGP 37849 (CGP) might affect some epigenetic markers in the adult medial prefrontal cortex (mPFC). Methods Histone H3 phosphorylation at serine 10 (H3S10ph), histone H3 acetylation at lysine 9 or 14 (H3K9ac or H3K14ac, respectively), or expression of histone deacetylase (HDAC) 2, HDAC5, myocyte enhancer factor (MEF) 2D and activity-regulated cytoskeleton-associated protein (Arc) were analysed. Moreover, we also evaluated whether the deacetylase inhibitor sodium butyrate (SB; 1.2 mg/kg, ip) could prevent behavioural and neurochemical changes in the mPFC induced by CGP during memory retrieval in the trace fear conditioning paradigm. Results The results showed that CGP administration increased the number of H3S10ph nuclei but did not affect H3K9ac and H3K14ac or HDAC2 protein levels. However, CGP administration altered the HDAC5 mRNA and protein levels and increased the mRNA and protein levels of MEF2D. CGP also increased Arc mRNA, which was correlated with an increase in the amount of Arc DNA bound to MEF2D. SB given 2 h after training prevented impairment of the freezing response and disruption of epigenetic markers (H3S10ph, HDAC5, MEF2D) and Arc expression during memory retrieval induced by CGP administration. Conclusions The early-life blockade of NMDA receptors impairs some epigenetic regulatory processes in the mPFC that are involved in fear memory formation.

scholarly journals The medial prefrontal cortex is critical for memory retrieval and resolving interference

2013 ◽  
Vol 20 (4) ◽  
pp. 201-209 ◽  
Author(s):  
G. J. Peters ◽  
C. N. David ◽  
M. D. Marcus ◽  
D. M. Smith
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Memory Retrieval

scholarly journals Dopamine modulates adaptive forgetting in medial prefrontal cortex

2021 ◽  
Author(s):  
Francisco Tomas Gallo ◽  
Maria Belen Zanoni-Saad ◽  
Juan Facundo Morici ◽  
Magdalena Miranda ◽  
Michael C Anderson ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Familiar Object ◽  
D1 Receptors ◽  
Long Term Memory ◽  
Dopamine Signaling ◽  
Induced Forgetting ◽  
Adaptive Forgetting

Active forgetting occurs in many species, but how the mechanisms that control behavior contribute to determining which memories are forgotten is still unknown. We previously found that when rats need to retrieve particular memories to guide exploration, it reduces later retention of other memories encoded in that environment. As with humans, this retrieval-induced forgetting relies on prefrontal control processes. The dopaminergic input to the prefrontal cortex is important for executive functions and cognitive flexibility. We found that, in a similar way, prefrontal dopamine signaling through D1 receptors is required for retrieval-induced forgetting in rats. Blockade of medial prefrontal cortex D1 receptors as animals encountered a familiar object impaired forgetting of the memory of a competing object in a subsequent long-term memory test. Inactivation of the ventral tegmental area produced the same pattern of behavior, a pattern that could be reversed by concomitant activation of prefrontal D1 receptors. We observed a bidirectional modulation of retrieval-induced forgetting by agonists and antagonists of D1 receptors in the medial prefrontal cortex. These findings establish the essential role of prefrontal dopamine in the active forgetting of competing memories, contributing to the shaping of retention in response to an organism behavioral goals.

scholarly journals A cortico-hippocampal scaffold for representing and recalling lifelike events

2021 ◽  
Author(s):  
Zachariah M Reagh ◽  
Charan Ranganath
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Real World ◽  
Memory Retrieval ◽  
Temporal Network ◽  
Specific Context ◽  
Pattern Similarity ◽  
Cortical Regions ◽  
Hippocampal Networks ◽  
Event Representations

Real-world events are complex, featuring elements that may be unique to, or shared across, multiple situations. In the present study, we used fMRI to identify how different event components are represented in real-time and during memory retrieval. Twenty participants viewed and recalled eight videos depicting real-world events, combining people, contexts, and context types. Multi-voxel pattern similarity analyses revealed specific person representations, persistent across contexts, in regions of an Anterior-Temporal Network. Conversely, we found specific context representations, persistent across people, in regions of a Posterior-Medial Network. We also found schema-like generalization across contexts in medial prefrontal cortex, and episodic specificity in the hippocampus. Event patterns were reinstated during recall, and hippocampal reinstatement predicted the number of details retrieved. Finally, we observed distinct representational timescales across the hippocampus and cortical regions. These findings reveal mechanisms for scaffolding different aspects of lifelike event representations in cortico-hippocampal networks as experiences are observed and recalled.

scholarly journals The Medial Prefrontal Cortex Is Involved in Spatial Memory Retrieval under Partial-Cue Conditions

2007 ◽  
Vol 27 (49) ◽  
pp. 13567-13578 ◽  
Author(s):  
Y. S. Jo ◽  
E. H. Park ◽  
I. H. Kim ◽  
S. K. Park ◽  
H. Kim ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Memory ◽  
Medial Prefrontal Cortex ◽  
Memory Retrieval
Sign in / Sign up

Export Citation Format

Share Document