scholarly journals Reliability-based topology optimization against geometric imperfections with random threshold model

2018 ◽  
Vol 115 (1) ◽  
pp. 99-116 ◽  
Author(s):  
Zhan Kang ◽  
Peishuo Liu
Keyword(s):  
Topology Optimization ◽  
Threshold Model ◽  
Geometric Imperfections ◽  
Random Threshold

Topology Optimization of IPM Motors using Fourier Series

2017 ◽  
Vol 137 (3) ◽  
pp. 245-253
Author(s):  
Hidenori Sasaki ◽  
Hajime Igarashi
Keyword(s):  
Fourier Series ◽  
Topology Optimization

Topology Optimization of Superconducting Electromagnets for Particle Accelerators

2019 ◽  
Vol 139 (9) ◽  
pp. 568-575
Author(s):  
Yusuke Sakamoto ◽  
Daisuke Ishizuka ◽  
Tetsuya Matsuda ◽  
Kazuhiro Izui ◽  
Shinji Nishiwaki
Keyword(s):  
Topology Optimization ◽  
Particle Accelerators

Topology Optimization using Deep Learning

2020 ◽  
Vol 140 (12) ◽  
pp. 858-865
Author(s):  
Hidenori Sasaki ◽  
Yuki Hidaka ◽  
Hajime Igarashi
Keyword(s):  
Deep Learning ◽  
Topology Optimization

Hyperstimulation of the immune system as a cause of autoimmune diseases

2020 ◽  
Vol 75 (3) ◽  
pp. 204-213
Author(s):  
Varvara A. Ryabkova ◽  
Leonid P. Churilov ◽  
Yehuda Shoenfeld
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Genetic Basis ◽  
Threshold Model ◽  
Subsequent Development ◽  
Threshold Effect ◽  
Successful Management ◽  
Polygenic Inheritance ◽  
Autoimmune Pathology ◽  
The Common

The pathogenesis of autoimmune diseases is very complex and multi-factorial. The concept of Mosaics of Autoimmunity was introduced to the scientific community 30 years ago by Y. Shoenfeld and D.A. Isenberg, and since then new tiles to the puzzle are continuously added. This concept specifies general pathological ideas about the multifactorial threshold model for polygenic inheritance with a threshold effect by the action of a number of external causal factors as applied to the field of autoimmunology. Among the external factors that can excessively stimulate the immune system, contributing to the development of autoimmune reactions, researchers are particularly interested in chemical substances, which are widely used in pharmacology and medicine. In this review we highlight the autoimmune dynamics i.e. a multistep pathogenesis of autoimmune diseases and the subsequent development of lymphoma in some cases. In this context several issues are addressed namely, genetic basis of autoimmunity; environmental immunostimulatory risk factors; gene/environmental interaction; pre-clinical autoimmunity with the presence of autoantibodies; and the mechanisms, underlying lymphomagenesis in autoimmune pathology. We believe that understanding the common model of the pathogenesis of autoimmune diseases is the first step to their successful management.

Sign in / Sign up

Export Citation Format

Share Document