Developmental shift in bidirectional functions of taurine-sensitive chloride channels during cortical circuit formation in postnatal mouse brain

2004 ◽  
Vol 60 (2) ◽  
pp. 166-175 ◽  
Author(s):  
Mika Yoshida ◽  
Satoshi Fukuda ◽  
Yusuke Tozuka ◽  
Yusei Miyamoto ◽  
Tatsuhiro Hisatsune
Keyword(s):  
Mouse Brain ◽  
Chloride Channels ◽  
Developmental Shift ◽  
Cortical Circuit ◽  
Circuit Formation

scholarly journals Characterization of the Subventricular-Thalamo-Cortical Circuit in the NP-C Mouse Brain, and New Insights Regarding Treatment

2019 ◽  
Vol 27 (8) ◽  
pp. 1507-1526 ◽  
Author(s):  
Min Hee Park ◽  
Byung Jo Choi ◽  
Min Seock Jeong ◽  
Ju Youn Lee ◽  
In Kyung Jung ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Cortical Circuit

Regulation of Cortical Circuit Formation

2013 ◽  
pp. 127-151
Author(s):  
Fernanda M. Rodríguez-Tornos ◽  
Beatriz Cubelos ◽  
Marta Nieto
Keyword(s):  
Cortical Circuit ◽  
Circuit Formation

scholarly journals Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex

2016 ◽  
Vol 212 (6) ◽  
pp. 721-736 ◽  
Author(s):  
Jianmin Su ◽  
Jiang Chen ◽  
Kumiko Lippold ◽  
Aboozar Monavarfeshani ◽  
Gabriela Lizana Carrillo ◽  
...  
Keyword(s):  
Neuronal Activity ◽  
Nerve Terminal ◽  
Inhibitory Synapses ◽  
Mammalian Brain ◽  
Nerve Terminals ◽  
Brain Disorders ◽  
Integrin Receptors ◽  
Developing Neocortex ◽  
Cortical Circuit ◽  
Circuit Formation

Inhibitory synapses comprise only ∼20% of the total synapses in the mammalian brain but play essential roles in controlling neuronal activity. In fact, perturbing inhibitory synapses is associated with complex brain disorders, such as schizophrenia and epilepsy. Although many types of inhibitory synapses exist, these disorders have been strongly linked to defects in inhibitory synapses formed by Parvalbumin-expressing interneurons. Here, we discovered a novel role for an unconventional collagen—collagen XIX—in the formation of Parvalbumin+ inhibitory synapses. Loss of this collagen results not only in decreased inhibitory synapse number, but also in the acquisition of schizophrenia-related behaviors. Mechanistically, these studies reveal that a proteolytically released fragment of this collagen, termed a matricryptin, promotes the assembly of inhibitory nerve terminals through integrin receptors. Collectively, these studies not only identify roles for collagen-derived matricryptins in cortical circuit formation, but they also reveal a novel paracrine mechanism that regulates the assembly of these synapses.

Social isolation produces glucocorticoid-mediated disruption of cortical circuit formation

2009 ◽  
Vol 65 ◽  
pp. S58
Author(s):  
Tomoyuki Miyazaki ◽  
Kenkichi Takase ◽  
Hirobumi Tada ◽  
Dai Mitsushima ◽  
Takuya Takahashi
Keyword(s):  
Social Isolation ◽  
Cortical Circuit ◽  
Circuit Formation

Chemical kindling decreases GABA-activated chloride channels of mouse brain

1989 ◽  
Vol 160 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Edward Lewin ◽  
Joanna Peris ◽  
Virginia Bleck ◽  
Nancy R. Zahniser ◽  
R. Adron Harris
Keyword(s):  
Mouse Brain ◽  
Chloride Channels ◽  
Chemical Kindling
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