scholarly journals Role of glial metabolism in diabetic encephalopathy as detected by high resolution13C NMR

2003 ◽  
Vol 16 (67) ◽  
pp. 440-449 ◽  
Author(s):  
María A. García-Espinosa ◽  
María L. García-Martín ◽  
Sebastián Cerdán
Keyword(s):  
Diabetic Encephalopathy

Role of microglia-neuron interactions in diabetic encephalopathy

2018 ◽  
Vol 42 ◽  
pp. 28-39 ◽  
Author(s):  
Yuan Liu ◽  
Mingchao Li ◽  
Zuo Zhang ◽  
Yun Ye ◽  
Jiyin Zhou
Keyword(s):  
Diabetic Encephalopathy ◽  
Neuron Interactions

The role of impaired insulin/IGF action in primary diabetic encephalopathy

2005 ◽  
Vol 1037 (1-2) ◽  
pp. 12-24 ◽  
Author(s):  
Zhen-guo Li ◽  
Weixian Zhang ◽  
Anders A.F. Sima
Keyword(s):  
Diabetic Encephalopathy ◽  
Impaired Insulin

scholarly journals Corrigendum: Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy

2019 ◽  
Vol 10 ◽  
Author(s):  
Anup Bhusal ◽  
Md Habibur Rahman ◽  
In-Kyu Lee ◽  
Kyoungho Suk
Keyword(s):  
Lipocalin 2 ◽  
Diabetic Encephalopathy

scholarly journals Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

Molecules ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 522 ◽  
Author(s):  
Yadong Zhai ◽  
Xiangbao Meng ◽  
Tianyuan Ye ◽  
Weijie Xie ◽  
Guibo Sun ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Nlrp3 Inflammasome ◽  
Cognitive Disorders ◽  
Anxiety And Depression ◽  
Inflammasome Activation ◽  
Diabetic Encephalopathy ◽  
Caspase 1 ◽  
Nlrp3 Inflammasome Activation

Diabetes is associated with a high risk of developing cognitive dysfunction and neuropsychiatric disabilities, and these disease symptomsare termed diabetic encephalopathy (DEP). Inflammation is involved in the development of DEP. The cleavage and maturation of the proinflammatory cytokine interleukin (IL)-1β is regulated by the NLRP3 inflammasome. Obese and type 2 diabetic db/db mice show anxiety- and depression-like behaviors and cognitive disorders associated with hippocampal inflammation. The purpose of this study was to explore the role of NLRP3 inflammasome in DEP. Results showed that expression levels of inflammasome components including NLRP3, apoptosis-associated speck-like protein (ASC), and caspase-1, as well as IL-1β in the hippocampus of diabetic db/db mice were higher than those of non-diabetic db/m mice. Treatment of db/db mice with NLRP3 inflammasome inhibitor MCC950 ameliorated anxiety- and depression-like behaviors as well as cognitive dysfunction, and reversed increased NLRP3, ASC, and IL-1βexpression levels and caspase-1 activity in hippocampus. Moreover, MCC950 treatment significantly improved insulin sensitivity in db/db mice. These results demonstrate that inhibition of NLRP3 inflammasome activation may prove to be a potential therapeutic approach for DEP treatment.

scholarly journals Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy

2019 ◽  
Vol 10 ◽  
Author(s):  
Anup Bhusal ◽  
Md Habibur Rahman ◽  
In-Kyu Lee ◽  
Kyoungho Suk
Keyword(s):  
Lipocalin 2 ◽  
Diabetic Encephalopathy

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

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