scholarly journals Diabetic encephalopathy: the role of oxidative stress and inflammation in type 2 diabetes

2012 ◽  
pp. 75
Author(s):  
Flávio Reis ◽  
Soares ◽  
Nunes ◽  
Pereira
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Diabetic Encephalopathy

Role of Oxidative Stress in Modulating Cutaneous Vasodilation and Sweating During Exercise in Type-2 Diabetes

2017 ◽  
Vol 49 (5S) ◽  
pp. 451
Author(s):  
Pegah Akbari ◽  
Naoto Fujii ◽  
Sheila Dervis ◽  
Robert D. Meade ◽  
Pierre Boulay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Cutaneous Vasodilation

scholarly journals Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Ana Díaz ◽  
Raúl López-Grueso ◽  
Juan Gambini ◽  
Daniel Monleón ◽  
Cristina Mas-Bargues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Replacement Therapy ◽  
Metabolic Profile ◽  
Estrogen Replacement Therapy ◽  
Diabetic Rats ◽  
Estrogen Replacement ◽  
Antioxidant Genes

Females live longer than males, and the estrogens are one of the reasons for this difference. We reported some years ago that estrogens are able to protect rats against oxidative stress, by inducing antioxidant genes. Type 2 diabetes is an age-associated disease in which oxidative stress is involved, and moreover, some studies show that the prevalence is higher in men than in women, and therefore there are sex-associated differences. Thus, the aim of this study was to evaluate the role of estrogens in protecting against oxidative stress in type 2 diabetic males and females. For this purpose, we used Goto-Kakizaki rats, which develop type 2 diabetes with age. We found that female diabetic rats showed lower glycaemia levels with age than did diabetic males and that estrogens enhanced insulin sensitivity in diabetic females. Moreover, glucose uptake, measured by positron emission tomography, was higher in the female brain, cerebellum, and heart than in those from male diabetic rats. There were also sex-associated differences in the plasma metabolic profile as determined by metabolomics. The metabolic profile was similar between estrogen-replaced and control diabetic rats and different from ovariectomized diabetic rats. Oxidative stress is involved in these differences. We showed that hepatic mitochondria from females produced less hydrogen peroxide levels and exhibited lower xanthine oxidase activity. We also found that hepatic mitochondrial glutathione oxidation and lipid oxidation levels were lower in diabetic females when compared with diabetic males. Ovariectomy induced oxidative stress, and estrogen replacement therapy prevented it. These findings provide evidence for estrogen beneficial effects in type 2 diabetes and should be considered when prescribing estrogen replacement therapy to menopausal women.

scholarly journals A Role of Oxidative Stress-Generated Eicosanoid in the Progression of Arteriosclerosis in Type 2 Diabetes Mellitus Model Rats

2002 ◽  
Vol 25 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Kaori SHINOMIYA ◽  
Megumu FUKUNAGA ◽  
Hideyasu KIYOMOTO ◽  
Katsufumi MIZUSHIGE ◽  
Teppei TSUJI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus

Protective Role of Terminalia superba Ethyl Acetate Extract Against Oxidative Stress in Type 2 Diabetes

Pharmacologia ◽  
2011 ◽  
Vol 2 (12) ◽  
pp. 355-361
Author(s):  
Ngueguim Tsofack Florence ◽  
Tabi Nkoulou Thierry ◽  
Dzeufiet Djomeni Paul Desir ◽  
Tsala David Emeryb ◽  
Dongmo Alain Blaise ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Protective Role ◽  
Terminalia Superba

scholarly journals Role of zinc in insulin regulation and diabetes

2017 ◽  
Vol 05 (02) ◽  
pp. 83-87
Author(s):  
Resham Poudel ◽  
Yuvaraj Bhusal ◽  
Biswaraj Tharu ◽  
Nisha Kafle
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Renal Damage ◽  
Hemoglobin A1c ◽  
Zn Deficiency ◽  
Improve Insulin Sensitivity ◽  
Potential Implication ◽  
Insulin Regulation

AbstractZinc (Zn) affects glucose metabolism through insulin regulation and has potential implication in diabetes. Zn deficiency has not been proven in diabetes; however, observations of hyperzincuria, hypozincemia, and Zn malabsorption in diabetes indicate additional requirements for Zn. Mutation in Zn transporter 8 – a key protein in insulin secretion – has been associated with Type 2 diabetes. Zn supplementation in prediabetics and diabetics has been supported to improve plasma glucose, hemoglobin A1c (HbA1c), and lipids and potentially improve insulin sensitivity, reduce oxidative stress, and protect from renal damage.

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