scholarly journals Diffusion MRI detects early brain microstructure abnormalities in 2‐month‐old 3×Tg‐AD mice

2020 ◽  
Vol 33 (9) ◽  
Author(s):  
Maria Fatima Falangola ◽  
Xingju Nie ◽  
Ralph Ward ◽  
Emilie T. McKinnon ◽  
Siddhartha Dhiman ◽  
...  
Keyword(s):  
Diffusion Mri ◽  
Brain Microstructure

scholarly journals Probing mouse brain microstructure using oscillating gradient diffusion MRI

2011 ◽  
Vol 67 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Manisha Aggarwal ◽  
Melina V. Jones ◽  
Peter A. Calabresi ◽  
Susumu Mori ◽  
Jiangyang Zhang
Keyword(s):  
Mouse Brain ◽  
Diffusion Mri ◽  
Gradient Diffusion ◽  
Brain Microstructure

scholarly journals Improved fidelity of brain microstructure mapping from single-shell diffusion MRI

2015 ◽  
Vol 26 (1) ◽  
pp. 268-286 ◽  
Author(s):  
Maxime Taquet ◽  
Benoit Scherrer ◽  
Nicolas Boumal ◽  
Jurriaan M. Peters ◽  
Benoit Macq ◽  
...  
Keyword(s):  
Diffusion Mri ◽  
Brain Microstructure ◽  
Single Shell

Measurements of brain microstructure and connectivity with diffusion MRI

2011 ◽  
Vol 2 (Supplement A) ◽  
pp. A99-A102
Author(s):  
Chun-Yi Zac Lo ◽  
Yong He ◽  
Ching-Po Lin
Keyword(s):  
Diffusion Mri ◽  
Brain Microstructure

scholarly journals Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

2018 ◽  
Vol 32 (4) ◽  
pp. e3998 ◽  
Author(s):  
Dmitry S. Novikov ◽  
Els Fieremans ◽  
Sune N. Jespersen ◽  
Valerij G. Kiselev
Keyword(s):  
Parameter Estimation ◽  
Diffusion Mri ◽  
Brain Microstructure

scholarly journals Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Minhui Ouyang ◽  
Qinmu Peng ◽  
Tina Jeon ◽  
Roy Heyne ◽  
Lina Chalak ◽  
...  
Keyword(s):  
Diffusion Mri ◽  
Prediction Models ◽  
Structural Basis ◽  
Support Vector ◽  
Neurodevelopmental Outcomes ◽  
Language Functions ◽  
Future Behavior ◽  
Brain Microstructure ◽  
Atypical Development ◽  
Cortical Regions

Cerebral cortical architecture at birth encodes regionally differential dendritic arborization and synaptic formation. It underlies behavioral emergence of 2-year-olds. Brain changes in 0–2 years are most dynamic across the lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development and identify biomarkers for early detection and tailored intervention in atypical development. Here we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at the age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as a potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.

scholarly journals Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds

2020 ◽  
Author(s):  
Minhui Ouyang ◽  
Qinmu Peng ◽  
Tina Jeon ◽  
Roy Heyne ◽  
Lina Chalak ◽  
...  
Keyword(s):  
Diffusion Mri ◽  
Prediction Models ◽  
Structural Basis ◽  
Support Vector ◽  
Neurodevelopmental Outcomes ◽  
Language Functions ◽  
Future Behavior ◽  
Brain Microstructure ◽  
Atypical Development ◽  
Cortical Regions

AbstractBrain cerebral cortical architecture encoding regionally differential dendritic arborization and synaptic formation at birth underlies human behavior emergence at 2 years of age. Brain changes in 0-2 years are most dynamic across lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development, and identify biomarkers for early detection and tailored intervention in atypical development. Here, we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.

scholarly journals Imaging brain microstructure with diffusion MRI: practicality and applications

2017 ◽  
Vol 32 (4) ◽  
pp. e3841 ◽  
Author(s):  
Daniel C. Alexander ◽  
Tim B. Dyrby ◽  
Markus Nilsson ◽  
Hui Zhang
Keyword(s):  
Diffusion Mri ◽  
Brain Microstructure

scholarly journals Diffusion MRI metrics of brain microstructure in Alzheimer’s disease: Boosting disease sensitivity with multi‐shell imaging and advanced pre‐processing

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Sophia I Thomopoulos ◽  
Talia M Nir ◽  
Julio E Villalon Reina ◽  
Neda Jahanshad ◽  
Paul M Thompson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Mri ◽  
Brain Microstructure

scholarly journals Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer’s disease

2013 ◽  
Vol 31 (6) ◽  
pp. 840-846 ◽  
Author(s):  
Maria F. Falangola ◽  
Jens H. Jensen ◽  
Ali Tabesh ◽  
Caixia Hu ◽  
Rachael L. Deardorff ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diffusion Mri ◽  
Brain Microstructure ◽  
Non Gaussian
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